Selected Antineoplastics/Strong & Moderate CYP3A4 Inducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may speed up how quickly your liver processes your cancer medicine.

What might happen:

The amount of your cancer medicine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your cancer medicine or change you to a medicine that does not interact with your cancer medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Inlyta (axitinib) US prescribing information. Pfizer Inc. June, 2020.
  • 2.Cotellic (cobimetinib) US prescribing information. Genentech, Inc. May, 2016.
  • 3.Lynparza (olaparib) capsules US prescribing information. AstraZenica Pharmaceuticals October 23, 2017.
  • 4.Lynparza (olaparib) tablets US prescribing information. AstraZenica Pharmaceuticals May, 2020.
  • 5.Ibrance (palbociclib) US prescribing information. Pfizer Labs April, 2019.
  • 6.Odomzo (sonidegib) US prescribing information. Novartis Pharmaceuticals May, 2019.
  • 7.Dirix L, Swaisland H, Verheul HM. Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies. Clin Ther 2016 Oct; 38(10):2286-2299.
  • 8.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: drug-interactions-table-substrates-inhibitors-and-inducers. Updated 11/14/2017.
  • 9.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2019..

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.