Apixaban; Edoxaban; Rivaroxaban/NSAIDs Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

These medicines decrease your body's ability to make clots.

What might happen:

Using these medicines together may increase your risk of bleeding.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have any unusual or unexpected bleeding such as bleeding from your gums, nosebleeds, unusual bruising, or dark stools.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Eliquis (apixaban) Australian prescribing information. Bristol-Myers Squibb Australia Pty. Ltd. July 21, 2011.
  • 2.Eliquis (apixaban) Canadian prescribing information. Bristol-Myers Squibb-Pfizer December, 13, 2011.
  • 3.Eliquis (apixaban) UK summary of product characterstics. Bristol-Myers Squibb/Pfizer EEIG, Bristol-Myers Squibb House November 19, 2012.
  • 4.Eliquis (apixaban) US prescribing information. Bristol-Myers Squibb Company July, 2016.
  • 5.Savaysa (edoxaban) US prescribing information. Daiichi Sankyo, Inc September, 2016.
  • 6.Xarelto (rivaroxaban) US prescribing information. Janssen Pharmaceuticals, Inc. June, 2017.