4-Aminobenzoic Acid, ABA, Acide 4-aminobenzoïque, Acide Aminobenzoïque, Acide p-aminobenzoïque, Acide Para-Amino-Benzoïque, Acide Paraaminobenzoïque, Acide Para-Aminobenzoïque, Acido Para Aminobenzoico, Aminobenzoic Acid, Aminobenzoate Potassium, Bacterial Vitamin H1, Ethyl Dihydroxypropyl Aminobenzoate, Glyceryl Paraaminobenzoate, Octyl Diemthyl PABA, P-Aminobenzoic Acid, Padamate O, Para-Aminobenzoate, Vitamin B10, Vitamin Bx, Vitamin H1, Vitamine B10, Vitamine Bactérienne H1, Vitamine Bx.<br/><br/>


Overview Information

Para-aminobenzoic acid (PABA) is a chemical found in the folic acid vitamin and also in several foods including grains, eggs, milk, and meat.

PABA is taken by mouth for skin conditions including vitiligo, pemphigus, dermatomyositis, morphea, lymphoblastoma cutis, Peyronie's disease, and scleroderma. PABA is also used to treat infertility in women, arthritis, "tired blood" (anemia), rheumatic fever, constipation, systemic lupus erythematosus (SLE), and headaches. It is also used to darken gray hair, prevent hair loss, make skin look younger, and prevent sunburn.

PABA is best known as a sunscreen that is applied to the skin (used topically).

PABA doesn't seem to be taken by mouth as often as it used to be, possibly because some people question its safety and effectiveness.

How does it work?

PABA is used as a sunscreen because it can block ultraviolet (UV) radiation to the skin.


Uses & Effectiveness?

Effective for

  • Sunburn. PABA is approved by the U.S. Food and Drug Administration (FDA) for use as a sunscreen. PABA seems to be effective during sweating, but not when skin is submerged in water - during swimming, for example.

Possibly Effective for

Possibly Ineffective for

  • Treating a condition that causes hardening or thickening of the skin (scleroderma). Although PABA is FDA-approved for scleroderma, there is only limited evidence that it is effective. Some research studies suggest it might help for some symptoms of scleroderma, but the most convincing evidence shows that it does not help.

Insufficient Evidence for

  • Skin condition called dermatomyositis. PABA is FDA approved for this skin condition. However, there is only limited evidence that it is effective.
  • Eye infection caused by herpes virus (herpes keratitis). Early research suggests that using a specific PABA eye solution (Actipol) as eye drops can be effective for treating herpes keratitis.
  • Patchy hardened skin (Morphea). PABA is FDA approved for use in people with this skin condition. However, there is limited evidence that it is effective.
  • Skin condition called pemphigus. PABA is FDA approved for use in people with this skin condition. However, there is limited evidence that it is effective.
  • Skin condition called vitiligo. PABA is FDA approved for use in people with this skin condition. However, there is limited evidence that it is effective.
  • Arthritis.
  • "Tired blood" (anemia).
  • Constipation.
  • Headaches.
  • Preventing hair loss.
  • Darkening gray hair.
  • Other conditions.
More evidence is needed to rate the effectiveness of PABA for these uses.

Side Effects

Side Effects & Safety

PABA is LIKELY SAFE for most people when applied directly to the skin. There have not been any reports of significant harm, although there have been reports that PABA increases the likelihood of sunburn in some people, even though it usually works as a sun block.

PABA is POSSIBLY SAFE when taken by mouth appropriately and when applied to the eyes as a solution. PABA can cause skin irritation and might also stain clothing with a yellow color. Nausea, vomiting, upset stomach, diarrhea, and loss of appetite might sometimes occur.

PABA is POSSIBLY UNSAFE when taken by mouth in high doses. Taking more than 12 grams per day can cause serious side effects such as liver, kidney, and blood problems.

Special Precautions & Warnings:

Children: When applied directly to the skin, PABA is LIKELY SAFE for children. PABA is POSSIBLY SAFE for children to take by mouth appropriately. Dose is important, as serious side effects can occur. PABA is POSSIBLY UNSAFE when taken by mouth in high doses. Some children who took doses of PABA greater than 220 mg/kg/day died.

Pregnancy and breast-feeding: PABA is LIKELY SAFE when applied to the skin during pregnancy or breast-feeding. However, there is not enough reliable information about the safety of taking PABA by mouth if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Kidney disease: PABA might build up in the kidneys making kidney disease worse. Do not use it if you have kidney problems.



Major Interaction

Do not take this combination

  • Antibiotics (Sulfonamide antibiotics) interacts with PARA-AMINOBENZOIC ACID (PABA)

    Para-aminobenzoic acid (PABA) can decrease the effectiveness of certain antibiotics called sulfonamides.<br/><br/> Some of these antibiotics include sulfamethoxazole (Gantanol), sulfasalazine (Azulfidine), sulfisoxazole (Gantrisin), and trimethoprim/sulfamethoxazole (Bactrim, Septra).

  • Dapsone (Avlosulfon) interacts with PARA-AMINOBENZOIC ACID (PABA)

    Dapsone (Avlosulfon) is used as an antibiotic. Para-aminobenzoic acid (PABA) might decrease the effectiveness of dapsone (Avlosulfon) for treating infections.

Moderate Interaction

Be cautious with this combination

  • Cortisone (Cortisone Acetate) interacts with PARA-AMINOBENZOIC ACID (PABA)

    The body breaks down cortisone to get rid of it. Para-aminobenzoic acid (PABA) might decrease how quickly the body breaks down cortisone. Taking PABA by mouth and getting a cortisone shot might increase the effects and side effects of cortisone.



The following doses have been studied in scientific research:



  • For Peyronie's disease: A specific PABA product (POTABA, Glenwood LLC.) 12 grams daily in four divided doses with meals for 8-24 months has been used.
  • For sunburn: Sunscreens with 1% to 15% PABA have been used.

  • For sunburn: Sunscreens with 1% to 15% PABA have been used.

View References


  • Serwin, A. B., Wasowicz, W., and Chodynicka, B. Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition 2006;22(9):860-864. View abstract.
  • Shaheen, S. O., Newson, R. B., Rayman, M. P., Wong, A. P., Tumilty, M. K., Phillips, J. M., Potts, J. F., Kelly, F. J., White, P. T., and Burney, P. G. Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax 2007;62(6):483-490. View abstract.
  • Shor-Posner, G., Lecusay, R., Miguez, M. J., Moreno-Black, G., Zhang, G., Rodriguez, N., Burbano, X., Baum, M., and Wilkie, F. Psychological burden in the era of HAART: impact of selenium therapy. Int J Psychiatry Med 2003;33(1):55-69. View abstract.
  • Sieja, K. Selenium (Se) deficiency in women with ovarian cancer undergoing chemotherapy and the influence of supplementation with this micro-element on biochemical parameters. Pharmazie 1998;53(7):473-476. View abstract.
  • Singh, U., Otvos, J., Dasgupta, A., de Lemos, J. A., Devaraj, S., and Jialal, I. High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy. Clin Chem 2007;53(3):525-528. View abstract.
  • Singhal, N. and Austin, J. A clinical review of micronutrients in HIV infection. J Int Assoc.Physicians AIDS Care (Chic.) 2002;1(2):63-75. View abstract.
  • Singletary, K. and Milner, J. Diet, autophagy, and cancer: a review. Cancer Epidemiol.Biomarkers Prev. 2008;17(7):1596-1610. View abstract.
  • Smolkova, B., Dusinska, M., Raslova, K., Barancokova, M., Kazimirova, A., Horska, A., Spustova, V., and Collins, A. Folate levels determine effect of antioxidant supplementation on micronuclei in subjects with cardiovascular risk. Mutagenesis 2004;19(6):469-476. View abstract.
  • Sole, M. J. and Jeejeebhoy, K. N. Conditioned nutritional requirements: therapeutic relevance to heart failure. Herz 2002;27(2):174-178. View abstract.
  • Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. View abstract.
  • Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469. View abstract.
  • Srivastava, K. C. Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic rings. Prostaglandins Leukot Med 1985;18:227-233.
  • Stevic, Z., Nicolic, A., and Blagojevic, D. A controlled trial of combination of methionine and antioxidants in ALS patients. Jugoslovenska Medicinska Biohemija 2011;20(4):223-228.
  • Stranges, S., Marshall, J. R., Trevisan, M., Natarajan, R., Donahue, R. P., Combs, G. F., Farinaro, E., Clark, L. C., and Reid, M. E. Effects of selenium supplementation on cardiovascular disease incidence and mortality: secondary analyses in a randomized clinical trial. Am J Epidemiol. 4-15-2006;163(8):694-699. View abstract.
  • Subudhi, A. W., Jacobs, K. A., Hagobian, T. A., Fattor, J. A., Fulco, C. S., Muza, S. R., Rock, P. B., Hoffman, A. R., Cymerman, A., and Friedlander, A. L. Antioxidant supplementation does not attenuate oxidative stress at high altitude. Aviat.Space Environ.Med 2004;75(10):881-888. View abstract.
  • Temple, K. A., Smith, A. M., and Cockram, D. B. Selenate-supplemented nutritional formula increases plasma selenium in hemodialysis patients. J Ren Nutr. 2000;10(1):16-23. View abstract.
  • Tessier, F., Hida, H., Favier, A., and Marconnet, P. Muscle GSH-Px activity after prolonged exercise, training, and selenium supplementation. Biol.Trace Elem.Res. 1995;47(1-3):279-285. View abstract.
  • Thomson, A. Nutritional support in acute pancreatitis. Curr.Opin.Clin.Nutr.Metab Care 2008;11(3):261-266. View abstract.
  • Trujillo, M., Ferrer-Sueta, G., and Radi, R. Peroxynitrite detoxification and its biologic implications. Antioxid.Redox.Signal. 2008;10(9):1607-1620. View abstract.
  • Turner-McGrievy, G. M., Barnard, N. D., Cohen, J., Jenkins, D. J., Gloede, L., and Green, A. A. Changes in nutrient intake and dietary quality among participants with type 2 diabetes following a low-fat vegan diet or a conventional diabetes diet for 22 weeks. J Am.Diet.Assoc. 2008;108(10):1636-1645. View abstract.
  • van, Dokkum W., Van der Torre, H. W., Schaafsma, G., Kistemaker, C., and Ockhuizen, T. Supplementation with selenium-rich bread does not influence platelet aggregation in healthy volunteers. Eur.J Clin.Nutr. 1992;46(6):445-450. View abstract.
  • Van, Gossum A. and Neve, J. Low selenium status in alcoholic cirrhosis is correlated with aminopyrine breath test. Preliminary effects of selenium supplementation. Biol.Trace Elem.Res. 1995;47(1-3):201-207. View abstract.
  • Vina, J., Sastre, J., Pallardo, F. V., Gambini, J., and Borras, C. Modulation of longevity-associated genes by estrogens or phytoestrogens. Biol Chem 2008;389(3):273-277. View abstract.
  • Vincent, J. L. and Forceville, X. Critically elucidating the role of selenium. Curr Opin Anaesthesiol. 2008;21(2):148-154. View abstract.
  • Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. View abstract.
  • Voitsekhovskaia, IuG, Skesters, A., Orlikov, G. A., Silova, A. A., Rusakova, N. E., Larmane, L. T., Karpov, IuG, Ivanov, A. D., and Maulins, E. [Assessment of some oxidative stress parameters in bronchial asthma patients beyond add-on selenium supplementation]. Biomed Khim. 2007;53(5):577-584. View abstract.
  • Volkovova, K., Barancokova, M., Kazimirova, A., Collins, A., Raslova, K., Smolkova, B., Horska, A., Wsolova, L., and Dusinska, M. Antioxidant supplementation reduces inter-individual variation in markers of oxidative damage. Free Radic.Res 2005;39(6):659-666. View abstract.
  • Wallace, K., Byers, T., Morris, J. S., Cole, B. F., Greenberg, E. R., Baron, J. A., Gudino, A., Spate, V., and Karagas, M. R. Prediagnostic serum selenium concentration and the risk of recurrent colorectal adenoma: a nested case-control study. Cancer Epidemiol.Biomarkers Prev. 2003;12(5):464-467. View abstract.
  • Weijl, N. I., Elsendoorn, T. J., Lentjes, E. G., Hopman, G. D., Wipkink-Bakker, A., Zwinderman, A. H., Cleton, F. J., and Osanto, S. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur.J Cancer 2004;40(11):1713-1723. View abstract.
  • Welch, R. W., Turley, E., Sweetman, S. F., Kennedy, G., Collins, A. R., Dunne, A., Livingstone, M. B., McKenna, P. G., McKelvey-Martin, V. J., and Strain, J. J. Dietary antioxidant supplementation and DNA damage in smokers and nonsmokers. Nutr.Cancer 1999;34(2):167-172. View abstract.
  • Wenzel, G., Kuklinski, B., Ruhlmann, C., and Ehrhardt, D. [Alcohol-induced toxic hepatitis--a "free radical" associated disease. Lowering fatality by adjuvant antioxidant therapy]. Z.Gesamte Inn.Med. 1993;48(10):490-496. View abstract.
  • Winterbourn, C. C., Chan, T., Buss, I. H., Inder, T. E., Mogridge, N., and Darlow, B. A. Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation. Pediatr.Res. 2000;48(1):84-90. View abstract.
  • Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H. D., Anker, S. D., Clark, A. L., and Cleland, J. G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005;26(21):2238-2244. View abstract.
  • Wood, L. G., Fitzgerald, D. A., Lee, A. K., and Garg, M. L. Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function. Am.J.Clin.Nutr. 2003;77(1):150-159. View abstract.
  • Xia, Y., Hill, K. E., Byrne, D. W., Xu, J., and Burk, R. F. Effectiveness of selenium supplements in a low-selenium area of China. Am.J.Clin.Nutr. 2005;81(4):829-834. View abstract.
  • Yamaguchi, T., Sano, K., Takakura, K., Saito, I., Shinohara, Y., Asano, T., and Yasuhara, H. Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke 1998;29(1):12-17. View abstract.
  • Yu, S. Y., Zhu, Y. J., Li, W. G., Huang, Q. S., Huang, C. Z., Zhang, Q. N., and Hou, C. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Biol.Trace Elem.Res. 1991;29(3):289-294. View abstract.
  • Zamora, A. J., Tessier, F., Marconnet, P., Margaritis, I., and Marini, J. F. Mitochondria changes in human muscle after prolonged exercise, endurance training and selenium supplementation. Eur.J Appl.Physiol Occup.Physiol 1995;71(6):505-511. View abstract.
  • Zhang, L., Gail, M. H., Wang, Y. Q., Brown, L. M., Pan, K. F., Ma, J. L., Amagase, H., You, W. C., and Moslehi, R. A randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for Helicobacter pylori infection on serum cholesterol and lipoproteins. Am.J.Clin.Nutr. 2006;84(4):912-919. View abstract.
  • Zima, T., Mestek, O., Nemecek, K., Bartova, V., Fialova, J., Tesar, V., and Suchanek, M. Trace elements in hemodialysis and continuous ambulatory peritoneal dialysis patients. Blood Purif. 1998;16(5):253-260. View abstract.
  • Zimmermann, T., Albrecht, S., Kuhne, H., Vogelsang, U., Grutzmann, R., and Kopprasch, S. [Selenium administration in patients with sepsis syndrome. A prospective randomized study]. Med Klin 9-15-1997;92 Suppl 3:3-4. View abstract.
  • Aaseth J, Haugen M, Forre O. Rheumatoid arthritis and metal compounds-perspectives on the role of oxygen radical detoxification. Analyst 1998;123:3-6. View abstract.
  • Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. View abstract.
  • Aggarwal R, Gathwala G, Yadav S, Kumar P. Selenium Supplementation for Prevention of Late-Onset Sepsis in Very Low Birth Weight Preterm Neonates. J Trop Pediatr. 2016;62(3):185-93. View abstract.
  • Aldosary BM, Sutter ME, Schwartz M, Morgan BW. Case series of selenium toxicity from a nutritional supplement. Clin Toxicol 2012;50(1):57-64. View abstract.
  • Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzymeQ10 for four years: follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS One. 2015;10(12):e0141641. View abstract.
  • Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013;167(5):1860-6. View abstract.
  • Algotar AM, Stratton MS, Ahmann FR, et al. Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer. Prostate 2013;73(3):328-35. View abstract.
  • Alhazzani W, Jacobi J, Sindi A, et al. The effect of selenium therapy on mortality in patients with sepsis syndrome: A systematic review and meta-analysis of randomized controlled trial. Crit Care Med 2013;41(6):1555-64. View abstract.
  • Arnaud J, Malvy D, Richard MJ, et al. Selenium status in an iodine deficient population of the West Ivory Coast. J Physiol Anthropol Appl Human Sci 2001;20:81-4.. View abstract.
  • Avenell A, Noble DW, Barr J, Engelhardt T. Selenium supplementation for critically ill adults. Cochrane Database Syst Rev 2004;(4):CD003703. View abstract.
  • Baeten JM, Mostad SB, Hughes MP, et al. Selenium deficiency is associated with shedding of HIV-1--infected cells in the female genital tract. J Acquir Immune Defic Syndr 2001;26:360-4.. View abstract.
  • Bahmani F, Kia M, Soleimani A, Asemi Z, Esmaillzadeh A. Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res. 2016;172(2):282-9. View abstract.
  • Balaz C, Feher J. The effect of selenium therapy on autoimmune thyroiditis. Clinical and Experimental Medical Journal 2009;3:269-77.
  • Baldew GS, Mol JG, de Kanter FJ, et al. The mechanism of interaction between cisplatin and selenite. Biochem Pharmacol 1991;41:1429-37. View abstract.
  • Baldew GS, van den Hamer CJ, Los G, et al. Selenium-induced protection against cis-diamminedichloroplatinum(II) nephrotoxicity in mice and rats. Cancer Res 1989;49:3020-3. View abstract.
  • Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. View abstract.
  • Baum MK, Campa A, Lai S, et al. Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naïve, HIV-infected adults in Botswana: A randomized clinical trial. JAMA 2013;310(20):2154-63. View abstract.
  • Baum MK, Miguez-Burbano MJ, Campa A, Shor-Posner G. Selenium and interleukins in persons infected with human immunodeficiency virus type 1. J Infect Dis 2000;182 Suppl 1:S69-73. View abstract.
  • Beck MA, Nelson HK, Shi Q, et al. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J 2001;15:1481-3. View abstract.
  • Berger MM, Binnert C, Baines M, et al. Trace element supplements influence protein metabolism and tissue levels after major burns. Intensive Care Med 2004;30(suppl):S61.
  • Berger MM, Reymond MJ, Shenkin A, et al. Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med 2001;27:91-100.. View abstract.
  • Berger MM, Shenkin A, Revelly JP, et al. Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients. Am J Clin Nutr 2004;80:410-6. View abstract.
  • Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr 1998;68:365-71. View abstract.
  • Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007;297:842-57. View abstract.
  • Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004;364:1219-28. View abstract.
  • Bleys J, Navas-Acien A, Guallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care 2007;30:829-34. View abstract.
  • Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality amoung US adults. Arch Intern Med 2008;168:404-10. View abstract.
  • Abarca, J., Odilla, Arrollo C., Blanch, S., and Arellano, G. [Melasma in pregnancy: reduction of its appearance with the use of a broad-spectrum photoprotective agent]. Med Cutan.Ibero.Lat.Am 1987;15(3):199-203. View abstract.
  • Akberova, S. I. [Actipol in treating stromal herpetic keratitis]. Vestn.Oftalmol. 2002;118(2):17-19. View abstract.
  • Akberova, S. I. [Para-aminobenzoic acid and prospects of its use in ophthalmology]. Vestn.Oftalmol. 2002;118(3):53-56. View abstract.
  • Akberova, S. I. and Musaev Galbinur, P. I. [The new interferon inducer Aktipol in the treatment of herpetic keratitis]. Vestn.Oftalmol. 2000;116(2):16-18. View abstract.
  • Akberova, S. I., Musaev Galbinur, P. I., Stroeva, O. G., Magomedov, N. M., Babaev, N. F., and Galbinur, A. P. [Comparative evaluation of the antioxidant activity of para-aminobenzoic acid and emoxipin in the cornea and crystalline lens (an experimental study)]. Vestn.Oftalmol. 2001;117(4):25-29. View abstract.
  • Akberova, S. I., Tazulakhova, E. B., Musaev Galbinur, P. I., Leont'eva, N. A., and Stroeva, O. G. [Study of interferon-inducing activity of para-aminobenzoic acid injected subconjunctivally in rabbits]. Vestn.Oftalmol. 1999;115(1):24-26. View abstract.
  • Alenda, O., Beley, S., Ferhi, K., Cour, F., Chartier-Kastler, E., Haertig, A., Richard, F., and Roupret, M. [Pathophysiology and management of Peyronie's disease in adult patients: an update]. Prog Urol. 2010;20(2):91-100. View abstract.
  • Antoniou, C., Kosmadaki, M. G., Stratigos, A. J., and Katsambas, A. D. Sunscreens--what's important to know. J Eur Acad.Dermatol Venereol. 2008;22(9):1110-1118. View abstract.
  • Beekwilder, J. P., O'Leary, M. E., van den Broek, L. P., van Kempen, G. T., Ypey, D. L., and van den Berg, R. J. Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain. J.Pharmacol.Exp.Ther. 2003;304(2):531-538. View abstract.
  • Davies, D. M. and Cavanagh, J. Jaundice from potassium p-aminobenzoate. Lancet 4-22-1967;1(7495):896. View abstract.
  • Dobrev, H., Popova, L., and Vlashev, D. Proteinase inhibitors and pemphigus vulgaris. An in vitro and in vivo study. Arch Dermatol Res 1996;288(11):648-655. View abstract.
  • Drozd, N. N., Makarov, V. A., Miftakhova, N. T., Kalugin, S. A., Stroeva, O. G., and Akberova, S. I. [Antithrombotic activity of para-aminobenzoic acid]. Eksp.Klin.Farmakol. 2000;63(3):40-44. View abstract.
  • Duffy, L. F., Kerzner, B., Seeff, L., Barr, S. B., and Soldin, S. J. Preliminary assessment of glycine conjugation of para-aminobenzoic acid as a quantitative test of liver function. Clin.Biochem. 1995;28(5):527-530. View abstract.
  • Ehlert, C., Strunz, H., Visser, K., Wiese, M., and Seydel, J. K. Inhibition of the conjugation of PABA with glycine in vitro by sulfamoyl benzoic acids, sulfonamides, and penicillins and its relation to tubular secretion. J Pharm.Sci 1998;87(6):785. View abstract.
  • Fisher, D. E., Lofton, S. P., Hale, T., Durant, N., and Grant, L. F. Peyronie's disease: a case study with clinical implications. Urol.Nurs. 2008;28(2):109-112. View abstract.
  • Flindt-Hansen, H. and Ebbesen, P. Ultraviolet light induction of peripheral granulocytosis with splenomegaly: protection of mice with topical p-aminobenzoic acid (PABA). Br J Dermatol 1991;125(3):222-226. View abstract.
  • Flindt-Hansen, H., Thune, P., and Eeg-Larsen, T. The effect of short-term application of PABA on photocarcinogenesis. Acta Derm.Venereol. 1990;70(1):72-75. View abstract.
  • Flindt-Hansen, H., Thune, P., and Larsen, T. E. The inhibiting effect of PABA on photocarcinogenesis. Arch.Dermatol Res 1990;282(1):38-41. View abstract.
  • Gaby, A. R. Natural remedies for scleroderma. Altern.Med.Rev. 2006;11(3):188-195. View abstract.
  • Griffiths, M. R. and Priestley, G. C. A comparison of morphoea and lichen sclerosus et atrophicus in vitro: the effects of para-aminobenzoate on skin fibroblasts. Acta Derm.Venereol. 1992;72(1):15-18. View abstract.
  • Grouls, R., Korsten, E., Ackerman, E., Hellebrekers, L., van Zundert, A., and Breimer, D. Diffusion of n-butyl-p-aminobenzoate (BAB), lidocaine and bupivacaine through the human dura-arachnoid mater in vitro. Eur.J.Pharm.Sci. 2000;12(2):125-131. View abstract.
  • Gur, S., Limin, M., and Hellstrom, W. J. Current status and new developments in Peyronie's disease: medical, minimally invasive and surgical treatment options. Expert.Opin.Pharmacother. 2011;12(6):931-944. View abstract.
  • Hasche-Klunder, R. [Treatment of peyronie's disease with para-aminobenzoacidic potassium (POTOBA) (author's transl)]. Urologe A 1978;17(4):224-227. View abstract.
  • Hellstrom, W. J. Medical management of Peyronie's disease. J Androl 2009;30(4):397-405. View abstract.
  • Hoek, F. J., Sanders, G. T., and Tytgat, G. N. Influence of gastric emptying on the PABA test. Clin Chim Acta 6-15-1987;165(2-3):235-241. View abstract.
  • Jarratt, M., Hill, M., and Smiles, K. Topical protection against long-wave ultraviolet A. J Am Acad.Dermatol 1983;9(3):354-360. View abstract.
  • Kierkegaard, E. and Nielsen, B. [Peyronie's disease treated with K-para-aminobenzoate and vitamin E]. Ugeskr.Laeger 7-23-1979;141(30):2052-2053. View abstract.
  • Korsten, H. H., Ackerman, E. W., Grouls, R. J., van Zundert, A. A., Boon, W. F., Bal, F., Crommelin, M. A., Ribot, J. G., Hoefsloot, F., and Slooff, J. L. Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient. Anesthesiology 1991;75(6):950-960. View abstract.
  • Larsen, S. M. and Levine, L. A. Peyronie's disease: review of nonsurgical treatment options. Urol.Clin North Am 2011;38(2):195-205. View abstract.
  • Leonard, F. and Kalis, B. [Photoprotection by drugs]. Rev Prat. 6-1-1992;42(11):1375-1376. View abstract.
  • Linn, E. E. Microemulsion of intradermal delivery of cetyl alcohol and octyl dimethyl PABA. Drug Development & Industrial Pharmacy 1990;16(6):899-920.
  • Mackie, B. S. and Mackie, L. E. The PABA story. Australas.J Dermatol 1999;40(1):51-53. View abstract.
  • Mohorn, M. and Knupfer, M. [Effectiveness of the calcium antagonist nifedipine and the protease inhibitor with plasmin inactivating effect para-aminomethylbenzoic acid on stress-induced bronchial asthma]. Z Gesamte Inn.Med 11-1-1984;39(21):527-530. View abstract.
  • Pan, C. W., Shen, Z. J., and Ding, G. Q. The effect of intravesical instillation of antifibrinolytic agents on bacillus Calmette-Guerin treatment of superficial bladder cancer: a pilot study. J Urol. 2008;179(4):1307-1311. View abstract.
  • Penneys, N. S. Treatment of lichen sclerosus with potassium para-aminobenzoate. J.Am.Acad.Dermatol. 1984;10(6):1039-1042. View abstract.
  • Pereira de Godoy, J. M. Aminaphtone in idiopathic cyclic oedema syndrome. Phlebology. 2008;23(3):118-119. View abstract.
  • Petri, H., Pierchalla, P., and Tronnier, H. [The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]. Schweiz.Rundsch.Med Prax. 11-20-1990;79(47):1457-1462. View abstract.
  • Priestley, G. C. and Brown, J. C. Effects of potassium para-aminobenzoate on growth and macromolecule synthesis in fibroblasts cultured from normal and sclerodermatous human skin, and rheumatoid synovial cells. J.Invest Dermatol. 1979;72(4):161-164. View abstract.
  • Pryor, J., Akkus, E., Alter, G., Jordan, G., Lebret, T., Levine, L., Mulhall, J., Perovic, S., Ralph, D., and Stackl, W. Peyronie's disease. J Sex Med. 2004;1(1):110-115. View abstract.
  • Rooney, J. F., Bryson, Y., Mannix, M. L., Dillon, M., Wohlenberg, C. R., Banks, S., Wallington, C. J., Notkins, A. L., and Straus, S. E. Prevention of ultraviolet-light-induced herpes labialis by sunscreen. Lancet 12-7-1991;338(8780):1419-1422. View abstract.
  • Sagone, A. L., Jr., Husney, R. M., and Davis, W. B. Biotransformation of para-aminobenzoic acid and salicylic acid by PMN. Free Radic.Biol.Med. 1993;14(1):27-35. View abstract.
  • Slapke, J., Hummel, S., Wischnewsky, G. G., and Winkler, J. Protease inhibitor prevents bronchoconstriction in man. Eur J Respir.Dis 1986;68(1):29-34. View abstract.
  • Stroeva, O. G., Akberova, S. I., Drozd, N. N., Makarov, V. A., Miftakhova, N. T., and Kalugin, S. S. [The antithrombotic activity of para-aminobenzoic acid in experimental thrombosis]. Izv.Akad.Nauk Ser.Biol 1999;(3):329-336. View abstract.
  • Taneva, E. [Pantogar--modern treatment of hair loss, structural hair lesions, early alopecia, and dystrophy of nails]. Akush.Ginekol.(Sofiia) 2002;41 Suppl 1:37-40. View abstract.
  • Taylor, C. R., Stern, R. S., Leyden, J. J., and Gilchrest, B. A. Photoaging/photodamage and photoprotection. J Am Acad.Dermatol 1990;22(1):1-15. View abstract.
  • Taylor, S. E. and Dorris, R. L. Modification of local anesthetic toxicity by vasoconstrictors. Anesth.Prog 1989;36(3):79-87. View abstract.
  • Trost, L. W., Gur, S., and Hellstrom, W. J. Pharmacological Management of Peyronie's Disease. Drugs 2007;67(4):527-545. View abstract.
  • van den Berg, R. J., Van Soest, P. F., Wang, Z., Grouls, R. J., and Korsten, H. H. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Anesthesiology 1995;82(6):1463-1473. View abstract.
  • Weidner, W., Hauck, E. W., and Schnitker, J. Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie's disease: a prospective, placebo-controlled, randomized study. Eur Urol 2005;47(4):530-535. View abstract.
  • Zarafonetis, C. J. and HORRAX, T. M. Treatment of Peyronie's disease with potassium para-aminobenzoate (potaba). J Urol. 1959;81(6):770-772. View abstract.
  • Carson CC. Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? Tech Urol 1997;3:135-9. View abstract.
  • Clegg DO, Reading JC, Mayes MD, et al. Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma. J Rheumatol 1994;21:105-10. View abstract.
  • Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  • Facts and Comparisons staff. Drug Facts and Comparisons. St Louis: Wolters Kluwer Company (updated monthly).
  • Hughes CG. Oral PABA and vitiligo. J Am Acad Dermatol 1983;9:770.
  • Jakobsen J, Pedersen AN, Ovesen L. Para-aminobenzoic acid (PABA) used as a marker for completeness of 24 hour urine: effects of age and dosage scheduling. Eur J Clin Nutr 2003;57:138-42. View abstract.
  • Kantor GR, Ratz JL. Liver toxicity from potassium para-aminobenzoate. J Am Acad Dermatol 1985;13:671-2.
  • Ludwig G. Evaluation of conservative therapeutic approaches to Peyronie's disease (fibrotic induration of the penis). Urol Int 1991;47:236-9. View abstract.
  • Pathak MA. Sunscreens: Topical and systemic approaches for protection of human skin against harmful effects of solar radiation. J Am Acad Dermatol 1982;7:285-312. View abstract.
  • Sieve BF. The clinical effects of a new B Complex Factor, para-aminobenzoic acid, on pigmentation and fertility. Southern Medicine & Surgery 1942;135-9.
  • Wiesel LL, Barritt AS, Stumpe WM. The synergistic action of para-aminobenzoic acid and cortisone in the treatment of rheumatoid arthritis. Am J Med Sci 1951;243-8.
  • Worobec S, LaChine A. Dangers of orally administered para-aminobenzoic acid. JAMA 1984;251:2348.
  • Zarafonetis CJ, Dabich L, DeVol EB, et al. Potassium para-aminobenzoate and liver function test findings. J Am Acad Dermatol 1986;15:144-9. View abstract.
  • Zarafonetis CJ, Dabich L, Devol EB, et al. Retrospective studies in scleroderma: pulmonary findings and effect of potassium p-aminobenzoate on vital capacity. Respiration 1989;56:22-33. View abstract.
  • Zarafonetis CJ, Dabich L, Negri D, et al. Retrospective studies in scleroderma: effect of potassium para-aminobenzoate on survival. J Clin Epidemiol 1988;41:193-205. View abstract.
  • Zarafonetis CJ, Dabich L, Skovronski JJ, et al. Retrospective studies in scleroderma: skin response to potassium para-aminobenzoate therapy. Clin Exp Rheumatol 1988;6:261-8. View abstract.
  • Zarafonetis CJ, Horrax TM. Treatment of peyronie's disease with para-aminobenzoacidic potassium (POTOBA). J Urol 1959;81:770-2.
  • Zarafonetis CJ. Darkening of gray hair during para-amino-benzoic acid therapy. J Invest Dermatol 1950;399-401.

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