Bovine Spleen, Concentré de Rate, Extracto de Bazo, Extrait de Rate, Extrait de Rate Hydrolysé, Extrait Splénique, Extrait Splénique Prédigéré, Facteurs Spléniques, Hydrolyzed Spleen Extract, Predigested Spleen Extract, Rate Bovine, Rate Crue, Raw Spleen, Spleen, Spleen Concentrate, Spleen Factors, Spleen Peptides, Spleen Polypeptides, Splenopentin, Tuftsin.


Overview Information

The spleen is an organ in people and animals. Its main jobs are to break down and remove old and damaged red blood cells and to provide some white blood cells to fight infection. Spleen extract is produced from animal spleens and is used as medicine.

People use spleen extract for conditions such low white blood cell counts, cancer, autoimmune diseases, infections, and many others, but there is no good scientific evidence to support these uses.

How does it work?

Spleen extract contains ingredients that are thought to stimulate the immune system.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of spleen extract for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: It is not known if spleen extract is safe or what the side effects might be. There is some concern about contamination of spleen extract from sick or diseased animals. In particular, there is concern that spleen extract might cause bovine spongiform encephalitis (BSE) due to contamination if obtained in countries where BSE has been reported. While this side effect hasn't been reported in humans, it's best to avoid using spleen extract from countries where BSE has been reported.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if spleen extract is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.



We currently have no information for SPLEEN EXTRACT Interactions.



The appropriate dose of spleen extract depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for spleen extract. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Agrawal, A. K. and Gupta, C. M. Tuftsin-bearing liposomes in treatment of macrophage-based infections. Adv.Drug Deliv.Rev. 3-30-2000;41(2):135-146. View abstract.
  • Kubo, S., Roh, M. S., Oyedeji, C., Romsdahl, M. M., and Nishioka, K. Effect of tuftsin on human Kupffer cell. Hepatogastroenterology 1998;45(24):2270-2274. View abstract.
  • Mathe, G. Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system? Cancer Detect.Prev.Suppl 1987;1:445-455. View abstract.
  • Naim, J. O., Lanzafame, R. J., and van Oss, C. J. The effect of anti-tuftsin antibody on the phagocytosis of bacteria by human neutrophils. Immunol.Invest 1991;20(5-6):499-506. View abstract.
  • Najjar, V. A. Tuftsin, a natural activator of phagocyte cells: an overview. Ann.N.Y.Acad.Sci. 1983;419:1-11. View abstract.
  • Nishioka, K. Migration enhancement by tuftsin of human mononuclear cells and its effect on the migration inhibition factor test with tumor antigens. Gann 1978;69(4):569-572. View abstract.
  • Nishioka, K., Amoscato, A. A., and Babcock, G. F. Tuftsin: a hormone-like tetrapeptide with antimicrobial and antitumor activities. Life Sci. 3-9-1981;28(10):1081-1090. View abstract.
  • Nishioka, K., Wagle, J. R., Rodriguez, T., Jr., Maeta, M., Kubo, S., and Dessens, S. E. Studies of human granulocyte phagocytosis stimulation by tuftsin. J.Surg.Res. 1994;56(1):94-101. View abstract.
  • Spirer, Z., Zakuth, V., Tzehoval, E., Dagan, S., Fridkin, M., Golander, A., and Melamed, I. Tuftsin stimulates IL-1 production by human mononuclear cells, human spleen cells and mouse spleen cells in vitro. J.Clin.Lab Immunol. 1989;28(1):27-31. View abstract.
  • Corazza GR, Zoli G, Ginaldi L, et al. Tuftsin deficiency in AIDS. Lancet 1991;337:12-3. View abstract.
  • Fridkin M, Najjar VA. Tuftsin: its chemistry, biology, and clinical potential. Crit Rev Biochem Mol Biol 1989;24:1-40. View abstract.
  • Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  • Murray MT. Encyclopedia of Nutritional Supplements. Rocklin, CA: Prima Health, 1996.
  • Volk HD, Eckert R, Diamantstein T, Schmitz H. [Immunorestitutive action of hydrolysates and ultrafiltrates of bovine spleen]. Arzneimittelforschung 1991;41:1281-5. View abstract.

Vitamins Survey

Have you ever purchased SPLEEN EXTRACT?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for SPLEEN EXTRACT

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.