Demling, R. H. and DeSanti, L. Effect of a hypocaloric diet, increased protein intake and resistance training on lean mass gains and fat mass loss in overweight police officers. Ann Nutr Metab 2000;44(1):21-29. View abstract.
Rzehak, P., Sausenthaler, S., Koletzko, S., Reinhardt, D., von, Berg A., Kramer, U., Berdel, D., Bollrath, C., Grubl, A., Bauer, C. P., Wichmann, H. E., and Heinrich, J. Long-term effects of hydrolyzed protein infant formulas on growth--extended follow-up to 10 y of age: results from the German Infant Nutritional Intervention (GINI) study. Am J Clin.Nutr 2011;94(6 Suppl):1803S-1807S. View abstract.
Agostoni C, Fiocchi A, Riva E, et al. Growth of infants with IgE-mediated cow's milk allergy fed different formulas in the complementary feeding period. Pediatr Allergy Immunol 2007;18(7):599-606. View abstract.
Borschel MW, Baggs GE, Barrett-Reis B. Growth of healthy term infants fed ready-to-feed and powdered forms of an extensively hydrolyzed casein-based infant formula: a randomized, blinded, controlled trial. Clin Pediatr (Phila) 2014;53(6):585-92. View abstract.
Borschel MW, Ziegler EE, Wedig RT, Oliver JS. Growth of healthy term infants fed an extensively hydrolyzed casein-based or free amino acid-based infant formula: a randomized, double-blind, controlled trial. Clin Pediatr (Phila) 2013;52(10):910-7. View abstract.
Chanson-Rolle A, Aubin F, Braesco V, Hamasaki T, Kitakaze M. Influence of the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One. 2015;10(11):e0142235. View abstract.
Cicero AFG, Aubin F, Azais-Braesco V, Borghi C. Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials. Am J Hypertens. 2013;26(3):442-9. View abstract.
Cicero AFG, Colletti A, Rosticci M, et al. Effect of Lactotripeptides (Isoleucine-Proline-Proline/Valine-Proline-Proline) on Blood Pressure and Arterial Stiffness Changes in Subjects with Suboptimal Blood Pressure Control and Metabolic Syndrome: A Double-Blind, Randomized, Crossover Clinical Trial. Metab Syndr Relat Disord. 2016;14(3):161-6. View abstract.
Claustre J, Toumi F, Trompette A, et al. Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum. Am J Physiol Gastrointest Liver Physiol 2002;283:G521-8. View abstract.
de Mattos AP, Ribeiro TC, Mendes PS, et al. Comparison of yogurt, soybean, casein, and amino acid-based diets in children with persistent diarrhea. Nutr Res 2009;29(7):462-9. View abstract.
Estrada Reyes E, Zepeda Ortega B, Ten Haaf D, et al. Symptom's resolution and growth outcome of children with cow's milk protein allergy consuming two hydrolyzed formulas: A retrospective study in Mexico. Front Allergy 2023;4:1073430. View abstract.
Fekete AA, Givens DA, Lovegrove JA. Casein-derived lactotripeptides reduce systolic and diastolic blood pressure in a meta-analysis of randomised clinical trials. Nutrients. 2015;7(1):659-81. View abstract.
Field KL, Kimball BA, Mennella JA, et al. Avoidance of hydrolyzed casein by mice. Physiol Behav 2008;93(1-2):189-99. View abstract.
Forsyth BW. Colic and the effect of changing formulas: a double-blind, multiple-crossover study. J Pediatr 1989;115(4):521-6. View abstract.
Geerts BF, van Dongen MG, Flameling B, et al. Hydrolyzed casein decreases posprandial glucose concentrations in T2DM patients irrespective of leucine content. J Diet Suppl 2011;8(3):280-92. View abstract.
Gill HS, Doull F, Rutherfurd KJ, Cross ML. Immunoregulatory peptides in bovine milk. Br J Nutr 2000;84:S111-7. View abstract.
Gourley GR, Arenda RA. beta-Glucuronidase and hyperbilirubinaemia in breast-fed and formula-fed babies. Lancet 1986;1:644-6. View abstract.
Gourley GR, Kreamer B, Arend R. The effect of diet on feces and jaundice during the first 3 weeks of life. Gastroenterology 1992;103(2):660-7. View abstract.
Gourley GR, Kreamer B, Cohnen M, Kosorok MR. Neonatal jaundice and diet. Arch Pediatr Adolesc Med 1999;153(2):184-8. View abstract.
Gourley GR, Kreamer BL, Cohnen M. Inhibition of beta-glucuronidase by casein hydrolysate formula. J Pediatr Gastroenterol 1997;25:267-72. View abstract.
Gourley GR, Li Z, Kreamer BL, Kosorok MR. A controlled, randomized, double-blind trial of prophylaxis against jaundice among breastfed newborns. Pediatrics 2005;116(2):385-91. View abstract.
Halken S, Hansen KS, Jacobsen HP, et al. Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention: a prospective, randomized study. Pediatr Allergy Immunol 2000;11(3):149-61. View abstract.
Harrison GG, Graver EJ, Vargas M, et al. Growth and adiposity of term infants fed whey-predominant or casein-predominant formulas or human milk. J Pediatr Gastroenterol Nutr 1987;6(5):739-47. View abstract.
Hautaniemi EJ, Tikkakoski AJ, Tahvanainen A, et al. Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome--a randomised, double-blind, placebo-controlled study. Br J Nutr. 2015;114(3):376-86. View abstract.
Horner K, Drummond E, O'Sullivan V, S C Sri Harsha P, Brennan L. Effects of a casein hydrolysate versus intact casein on gastric emptying and amino acid responses. Eur J Nutr. 2019;58(3):955-964. View abstract.
Ibero M, Bone J, Martin B, Martinez J. Evaluation of an extensively hydrolysed casein formula (Damira 2000) in children with allergy to cow's milk proteins. Allergol Immunopathol (Madr) 2010;38(2):60-8. View abstract.
Igase M, Okada Y, Igase K, et al. Casein Hydrolysate Containing Milk-Derived Peptides Reduces Facial Pigmentation Partly by Decreasing Advanced Glycation End Products in the Skin: A Randomized Double-Blind Placebo-Controlled Trial. Rejuvenation Res 2021;24(2):97-103. View abstract.
Iskedjian M, Szajewska H, Spieldenner J, et al. Meta-analysis of a partially hydrolysed 100%-whey infant formula vs. extensively hydrolysed infant formulas in the prevention of atopic dermatitis. Curr Med Res Opin 2010;26(11):2599-606. View abstract.
Jakobsson I, Lothe L, Ley D, Borschel MW. Effectiveness of casein hydrolysate feedings in infants with colic. Acta Paediatr 2000;89(1):18-21. View abstract.
Jonker JT, Wijngaarden MA, Kloek J, et al. Effects of low doses of casein hydrolysate on post-challenge glucose and insulin levels. Eur J Intern Med 2011;22(3):245-8. View abstract.
Kerure AS, Udare S, Vispute C. Role of Lactium
™ in Psychodermatology: The CERTAIN Trial(#) on Patients with Acne Vulgaris. Dermatol Res Pract 2022;2022:2916317.View abstract.
Kim HJ, Kim J, Lee S, et al. A Double-Blind, Randomized, Placebo-Controlled Crossover Clinical Study of the Effects of Alpha-s1 Casein Hydrolysate on Sleep Disturbance. Nutrients. 2019;11(7):1466. View abstract.
Knip M, Virtanen SM, Becker D, et al. Early feeding and risk of type 1 diabetes: Experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR). Am J Clin Nutr 2011;94(6 Suppl):1814S-1820S. View abstract.
Knip M, Virtanen SM, Seppa K, et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010;363(20):1900-8. View abstract.
Koopman R, Crombach N, Gijsen AP, et al. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am J Clin Nutr 2009;90(1):106-15. View abstract.
Laatikainen R, Salmenkari H, Sibakov T, Vapaatalo H, Turpeinen A. Randomised Controlled Trial: Partial Hydrolysation of Casein Protein in Milk Decreases Gastrointestinal Symptoms in Subjects with Functional Gastrointestinal Disorders. Nutrients. 2020;12(7):2140. View abstract.
Mallet E, Henocq A. Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants. J Pediatr 1992;121(5 Pt 2):S95-100. View abstract.
Manders RJ, Hansen D, Zorenc AH, et al. Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. J Med Food 2014;17(7):758-63. View abstract.
Manders RJ, Koopman R, Sluijsmans WE, et al. Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in type 2 diabetic men. J Nutr 2006;136(5):1294-9. View abstract.
Manders RJ, Praet SF, Meex RC, et al. Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients. Diabetes Care 2006;29(12):2721-2. View abstract.
Manders RJ, Praet SF, Vikstrom MH, et al. Protein hydrolysate co-ingestion does not modulate 24 h glycemic control in long-standing type 2 diabetes patients. Eur J Clin Nutr 2009;63(1):121-6. View abstract.
Manders RJ, Wagenmakers AJ, Koopman R, et al. Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes. Am J Clin Nutr 2005;82(1):76-83. View abstract.
Nishi T, Hara H, Hira T, Tomita F. Dietary protein peptic hydrosylates stimulate cholecystokinin release via direct sensing by rat intestinal mucosal cells. Exp Biol Med (Maywood) 2001;226:1031-6. View abstract.
Oldaeus G, Anjou K, Bjorksten B, et al. Extensively and partially hydrolysed infant formulas for allergy prophylaxis. Arch Dis Child 1997;77(1):4-10. View abstract.
Paquete AT, Martins R, Connolly MP, Hegar B, Munasir Z, Stephanus S. Managing Cow's Milk Protein Allergy in Indonesia: A Cost-effectiveness Analysis of Hypoallergenic Milk Formulas from the Private Payers' Perspective. J Health Econ Outcomes Res 2022;9(2):77-85. View abstract.
Park O, Swaisgood HE, Allen JC. Calcium binding of phosphopeptides derived from hydrolysis of alpha s-casein or beta-casein using immobilized trypsin. J Dairy Sci 1998;81:2850-7. View abstract.
Pedrosa M, Pascual CY, Larco JI, Esteban MM. Palatability and hydrolysates and other substitution formulas for cow's milk-allergic children: a comparative study of taste, smell, and texture evaluated by healthy volunteers. J Investig Allergol Clin Immunol 2006;16(6):351-6. View abstract.
Qin LQ, Xu JY, Dong JY, Zhao Y, van Bladeren P, Zhang W. Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials. Nutr Metab Cardiovasc Dis. 2013;23(5):395-402. View abstract.
Roy CC, Darling P. Pitfalls in the design and manufacture of infant formulas. J Pediatr Gastroenterol Nutr 1983;2 Suppl 1:S282-92. View abstract.
Rzehak P, Sausenthaler S, Koletzko S, et al. Short- and long-term effects of feeding hydrolyzed protein infant formulas on growth at = 6 y of age: Results from the German Infant Nutritional Intervention Study. Am J Clin Nutr 2009;89(6):1846-56. View abstract.
Sakata Y, Yoshida C, Fujiki Y, et al. Effects of Casein Hydrolysate Ingestion on Thermoregulatory Responses in Healthy Adults during Exercise in Heated Conditions: A Randomized Crossover Trial. Nutrients. 2020;12(3):867. View abstract.
Sampson HA, Bernhisel-Broadbent J, Yang E, Scanlon SM. Safety of casein hydrolysate formula in children with cow milk allergy. J Pediatr 1991;118(4 Pt 1):520-5. View abstract.
Saunders MJ, Moore RW, Kies AK, et al. Carbohydrate and protein hydrolysate coingestions improvement of late-exercise time-trial performance. Int J Sport Nutr Exerc Metab 2009;19(2):136-49. View abstract.
Tauzin J, Miclo L, Gaillard JL. Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett 2002;531:369-74. View abstract.
Terheggen-Lagro SW, Khouw IM, Schaafsma A, Wauters EA. Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study. BMC Pediatr 2002;2:10. View abstract.
Thiagarajah K, Chee HP, Sit NW. Effect of Alpha-S1-Casein Tryptic Hydrolysate and L-Theanine on Poor Sleep Quality: A Double Blind, Randomized Placebo-Controlled Crossover Trial. Nutrients 2022;14(3):652. View abstract.
Tomiyama H, Fujii M, Shiina K, et al. Effects of Lactotripeptide Supplementation on Tele-Monitored Home Blood Pressure and on Vascular and Renal Function in Prehypertension - Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study. Circ Rep 2019;1(10):438-444. View abstract.
Townsend RR, McFadden CB, Ford V, Cadee JA. A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension. Am J Hypertens 2004;17(11 Pt 1):1056-8. View abstract.
Turpeinen AM, Järvenpää S, Kautiainen H, Korpela R, Vapaatalo H. Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis. Ann Med. 2013;45(1):51-6. View abstract.
Verdijk LB, Jonkers RA, Gleeson BG, et al. Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men. Am J Clin Nutr 2009;89(2):608-16. View abstract.
Virtanen SM, Cuthbertson D, Couluris M, Savilahti E, Knip M, Krischer JP; TRIGR Investigators. Effect of extensively hydrolyzed casein vs. conventional formula on the risk of asthma and allergies: The TRIGR randomized clinical trial. Pediatr Allergy Immunol 2021;32(4):670-678. View abstract.
von Berg A, Filipiak-Pittroff B, Kramer U, et al. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 2008;121(6):1442-7. View abstract.
von Berg A, Koletzko S, Filipiak-Pittroff B, et al. Certain hydrolyzed formulas reduce the incidence of atopic dermatitis but not that of asthma: three-year results of the German Infant Nutritional Intervention Study. J Allergy Clin Immunol 2007;119(3):718-25. View abstract.
von Berg A, Koletzko S, Grubl A, et al. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003;111(3):533-40. View abstract.
Wal JM. Cow's milk proteins/allergens. Ann Allergy Asthma Immunol 2002;89:3-10. View abstract.
Wal JM. Structure and function of milk allergens. Allergy 2001;56:35-8. View abstract.
Yamamoto N. Antihypertensive peptides derived from foods. Biopoly 1997;43:129-34.
Zhou S, Xu T, Zhang X, Luo J, An P, Luo Y. Effect of Casein Hydrolysate on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2022;14(19):4207. View abstract.