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Overview Information

Casein is the main protein in milk. It is the ingredient in milk that solidifies when milk curdles. When people drink milk, digestive juices break down the casein into protein pieces called casein peptides. Casein peptides can also be made in the laboratory and marketed as dietary supplements.

Casein peptides are used for high blood pressure, high cholesterol, anxiety, fatigue, epilepsy, intestinal disorders, cancer prevention, and stress reduction.

How does it work?

Some casein peptides are thought to cause blood vessels to enlarge in diameter and therefore lower blood pressure.


Uses & Effectiveness?

Insufficient Evidence for

  • High blood pressure. Early research shows that taking a specific casein peptide twice in one day does not reduce blood pressure.
  • High cholesterol.
  • Anxiety.
  • Fatigue.
  • Epilepsy.
  • Intestinal disorders.
  • Cancer prevention.
  • Reducing stress.
  • Other conditions.
More evidence is needed to rate the effectiveness of casein peptides for these uses.

Side Effects

Side Effects & Safety

Casein peptides are normally consumed in the diet from milk products. But there isn't enough information to know if casein peptides in dietary supplements are safe.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of casein peptides during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Milk allergy: People with milk allergy are allergic to the proteins contained in milk. They may also be allergic to fragments of milk proteins, such as casein peptides. If you have a milk allergy, it's best to avoid taking casein peptides.

Surgery: Casein peptides might affect blood pressure. There is some concern that casein peptides might interfere with blood pressure control during and after surgery. Stop taking casein peptides at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications for high blood pressure (Antihypertensive drugs) interacts with CASEIN PEPTIDES

    Some casein peptides might decrease blood pressure. Taking casein peptides along with medications for high blood pressure might cause your blood pressure to go too low.
    Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.



The appropriate dose of casein peptides depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for casein peptides. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Claustre J, Toumi F, Trompette A, et al. Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum. Am J Physiol Gastrointest Liver Physiol 2002;283:G521-8. View abstract.
  • Gill HS, Doull F, Rutherfurd KJ, Cross ML. Immunoregulatory peptides in bovine milk. Br J Nutr 2000;84:S111-7. View abstract.
  • Nishi T, Hara H, Hira T, Tomita F. Dietary protein peptic hydrosylates stimulate cholecystokinin release via direct sensing by rat intestinal mucosal cells. Exp Biol Med (Maywood) 2001;226:1031-6. View abstract.
  • Park O, Swaisgood HE, Allen JC. Calcium binding of phosphopeptides derived from hydrolysis of alpha s-casein or beta-casein using immobilized trypsin. J Dairy Sci 1998;81:2850-7. View abstract.
  • Tauzin J, Miclo L, Gaillard JL. Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alphaS2-casein. FEBS Lett 2002;531:369-74. View abstract.
  • Townsend RR, McFadden CB, Ford V, Cadee JA. A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension. Am J Hypertens 2004;17(11 Pt 1):1056-8. View abstract.
  • Wal JM. Cow's milk proteins/allergens. Ann Allergy Asthma Immunol 2002;89:3-10. View abstract.
  • Wal JM. Structure and function of milk allergens. Allergy 2001;56:35-8. View abstract.
  • Yamamoto N. Antihypertensive peptides derived from foods. Biopoly 1997;43:129-34.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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