WHEY PROTEIN

OTHER NAME(S):

Bovine Whey Protein Concentrate, Concentré de Protéine de Petit-Lait Bovin, Fraction de Lactosérum, Fraction de Petit-Lait, Goat Milk Whey, Goat Whey, Isolat de Protéine de Lactosérum, Isolat de Protéine de Petit-Lait, Lactosérum de Lait de Chèvre, MBP, Milk Protein, Milk Protein Isolate, Mineral Whey Concentrate, Proteínas del Suero de la Leche, Protéine de Lactosérum, Protéine de Lait, Protéine de Petit-Lait, Whey, Whey Fraction, Whey Peptides, Whey Protein Concentrate, Whey Protein Hydrolysate, Whey Protein Isolate, WPC, WPI.<br/><br/>

Overview

Overview Information

Whey protein is the protein contained in whey, the watery portion of milk that separates from the curds when making cheese.

Whey protein is commonly used for improving athletic performance and increasing strength, but evidence to support these uses is mixed. Whey protein is also used to reverse weight loss in people with HIV and to help prevent allergic conditions in infants.

How does it work?

Whey protein is a source of protein that might improve the nutrient content of the diet. Whey protein might also have effects on the immune system.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Eczema. Research shows that infants who consume whey protein by mouth during the first 3-12 months of life have a lower risk of developing red, itchy skin by the age of 3 years.
  • A condition associated with an increased risk for developing allergic reactions (atopic disease). Research shows that infants who consume whey protein by mouth during the first 3-12 months of life are less likely to be prone to allergies and allergic reactions compared to infants who receive standard formula. However, taking why protein might not be helpful for treating atopic diseases once they develop.
  • Weight loss in people with HIV/AIDS. Some research shows that taking whey protein by mouth can help decrease weight loss in people with HIV.
  • Red, scaly skin (plaque psoriasis). Some evidence shows that taking a specific whey protein extract daily for 8 weeks can reduce psoriasis symptoms.

Possibly Ineffective for

  • A lung disease called chronic obstructive pulmonary disease (COPD). Some research shows that taking a specific whey protein supplement daily for 6 weeks can improve shortness of breath but not lung function or quality of life in people with COPD. Other research suggests that taking whey protein supplements does not improve lung function, muscle function, or exercise in people with COPD.
  • Osteoporosis. Research suggests that taking a drink containing whey protein daily for up to 2 years does not improve bone density in postmenopausal women with osteoporosis.

Insufficient Evidence for

  • Muscle loss in the elderly. Whey protein might help to increase how much muscle older people have. However, it only seems to work when it is taken with other compounds like creatine or some fats, or with vitamins and minerals like calcium and vitamin D. Also, it is not known if whey protein helps build muscle in women or if it helps to increase strength.
  • Asthma. Early research suggests that taking a specific type of whey protein daily for 30 days does not improve lung function in children with asthma.
  • Athletic performance. Some research shows that taking whey protein in combination with strength training increases lean body mass, strength, and muscle size in healthy young adults. Taking whey protein also appears to improve running speed and recovery from exercise in untrained adults. But it does not appear to improve running speed or recovery in trained athletes. Taking whey protein also doesn’t seem to improve strength or muscle mass in overweight men with high cholesterol.
  • Cancer. There is some evidence that taking whey protein might help reduce tumor size in some people with cancer that has spread.
  • Cystic fibrosis. Early research suggests that taking whey protein daily for 28 days improves lung function in children, but not adults with cystic fibrosis.
  • Diabetes. Early research shows that consuming a specific drink containing whey protein concentrate before a meal decreases blood sugar in people with diabetes.
  • Asthma caused by exercise. Early research suggests that taking whey protein daily for 10 days improves lung function in people with asthma caused by exercise.
  • Liver disease (hepatitis). Early research suggests that taking a specific type of whey protein daily for 12 weeks can improve liver function in some people with hepatitis B. However, it does not appear to benefit people with hepatitis C.
  • HIV/AIDS. Early research suggests that taking whey protein for 4 months does not improve immune function in children with HIV.
  • Infections developed while in the hospital. Early research suggests that taking a specific whey protein supplement daily for up to 28 days has a similar effect on the rate of hospital-acquired infections as taking a combination of zinc, selenium, glutamine, and metoclopramide.
  • High cholesterol. Early research suggests that taking whey protein daily while participating in weight lifting exercises does not reduce cholesterol levels or body fat in overweight men with high cholesterol.
  • High blood pressure. Taking 28 grams of whey protein or 20 grams of hydrolyzed whey protein daily for 6-8 weeks can lower blood pressure in people with high blood pressure. But taking low amounts of whey protein (2.6 grams daily) doesn’t have any benefit.
  • Muscular disease (mitochondrial myopathies). Early research suggests that taking a whey protein supplement daily for one month does not improve muscle strength or quality of life in people with mitochondrial diseases.
  • Liver disease not due to alcohol use (nonalcoholic steatohepatitis, NASH). Early research suggests that taking whey protein daily for 12 weeks can improve liver function in patients with NASH.
  • Parkinson's disease. Some research shows that taking whey protein doesn't help Parkinson's disease symptoms.
  • An ovary disorder known as polycystic ovary syndrome (PCOS). Early research suggests that taking a supplement containing whey protein daily for 2 months can reduce body weight, fat mass, and cholesterol in people with ovarian cysts. However, whey protein does not improve blood sugar and seems to decrease high-density lipoprotein (HDL or "good") cholesterol.
  • Aching and stiffness caused by inflammation (polymyalgia rheumatica). Early research suggests that taking whey protein in a dairy product twice daily for 8 weeks does not improve muscle function, walking speed, or other movement tests in people with polymyalgia rheumatica.
  • Weight loss. The effects of whey protein on weight loss seem to vary depending on whether it is used alone or along with dieting or exercise. Taking whey protein along with dieting might prevent the loss of lean muscle and increase the loss of body fat in people who are obese or overweight. This might improve overall body composition. But taking whey protein while dieting doesn’t seem to increase overall weight loss in most people who are obese or overweight. It’s too soon to know if taking whey protein without dieting improves weight loss. When used along with exercise, whey protein doesn’t seem to improve weight loss compared to exercise alone. In overweight teens, drinking a whey protein beverage for 12 weeks seems to increase weight and body mass index (BMI).
  • Other conditions.
More evidence is needed to rate whey protein for these uses.

Side Effects

Side Effects & Safety

Whey protein is LIKELY SAFE for most children and adults when taken by mouth appropriately. High doses can cause some side effects such as increased bowel movements, nausea, thirst, bloating, cramps, reduced appetite, tiredness (fatigue), and headache.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking whey protein if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Milk allergy: If you are allergic to cow's milk, avoid using whey protein.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Levodopa interacts with WHEY PROTEIN

    Whey protein might decrease how much levodopa the body absorbs. By decreasing how much levodopa the body absorbs, whey protein might decrease the effectiveness of levodopa. Do not take whey protein and levodopa at the same time.

Moderate Interaction

Be cautious with this combination

!
  • Alendronate (Fosamax) interacts with WHEY PROTEIN

    Whey protein can decrease how much alendronate (Fosamax) the body absorbs. Taking whey protein and alendronate (Fosamax) at the same time can decrease the effectiveness of alendronate (Fosamax). Don't take whey protein within two hours of taking alendronate (Fosamax).

  • Antibiotics (Quinolone antibiotics) interacts with WHEY PROTEIN

    Whey protein might decrease how much antibiotic the body absorbs. Taking whey protein along with some antibiotics might decrease the effectiveness of some antibiotics. To avoid this interaction take whey protein supplements at least one hour after antibiotics.<br/><br/> Some of these antibiotics that might interact with whey protein include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).

  • Antibiotics (Tetracycline antibiotics) interacts with WHEY PROTEIN

    Whey protein contains calcium. The calcium in whey protein can attach to tetracyclines in the stomach. This decreases the amount of tetracyclines that can be absorbed. Taking calcium with tetracyclines might decrease the effectiveness of tetracyclines. To avoid this interaction take whey protein two hours before or four hours after taking tetracyclines.<br/><br/> Some tetracyclines include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

Dosing

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

  • For HIV/AIDS-related weight loss: 8.4-84 grams of whey protein per day, 2.4 grams/kg per day in a high-calorie formula, or 42-84 grams per day in a glutamine-enriched formula.
  • For red, scaly skin (plaque psoriasis): 5 grams per day of a specific whey protein extract product.

View References

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  • Agin, D., Kotler, D. P., Papandreou, D., Liss, M., Wang, J., Thornton, J., Gallagher, D., and Pierson, R. N., Jr. Effects of whey protein and resistance exercise on body composition and muscle strength in women with HIV infection. Ann.N.Y.Acad.Sci. 2000;904:607-609. View abstract.
  • Akhavan, T., Luhovyy, B. L., and Anderson, G. H. Effect of drinking compared with eating sugars or whey protein on short-term appetite and food intake. Int J Obes.(Lond) 8-24-2010; View abstract.
  • Akhavan, T., Luhovyy, B. L., Brown, P. H., Cho, C. E., and Anderson, G. H. Effect of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults. Am J Clin Nutr 2010;91(4):966-975. View abstract.
  • Aldrich, N. D., Reicks, M. M., Sibley, S. D., Redmon, J. B., Thomas, W., and Raatz, S. K. Varying protein source and quantity do not significantly improve weight loss, fat loss, or satiety in reduced energy diets among midlife adults. Nutr Res 2011;31(2):104-112. View abstract.
  • Alexander, D. D. and Cabana, M. D. Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysis. J Pediatr Gastroenterol.Nutr 2010;50(4):422-430. View abstract.
  • Alexander, D. D., Schmitt, D. F., Tran, N. L., Barraj, L. M., and Cushing, C. A. Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature. Nutr Rev. 2010;68(4):232-245. View abstract.
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  • Almaas, H., Holm, H., Langsrud, T., Flengsrud, R., and Vegarud, G. E. In vitro studies of the digestion of caprine whey proteins by human gastric and duodenal juice and the effects on selected microorganisms. Br J Nutr 2006;96(3):562-569. View abstract.
  • Alvarez, L. I., Saumell, C. A., Sanchez, S. F., and Lanusse, C. E. Plasma disposition kinetics of albendazole metabolites in pigs fed different diets. Res Vet.Sci 1996;60(2):152-156. View abstract.
  • Anderson, G. H., Tecimer, S. N., Shah, D., and Zafar, T. A. Protein source, quantity, and time of consumption determine the effect of proteins on short-term food intake in young men. J Nutr 2004;134(11):3011-3015. View abstract.
  • Antonione, R., Caliandro, E., Zorat, F., Guarnieri, G., Heer, M., and Biolo, G. Whey protein ingestion enhances postprandial anabolism during short-term bed rest in young men. J Nutr 2008;138(11):2212-2216. View abstract.
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  • Arnberg, K., Molgaard, C., Michaelsen, K. F., Jensen, S. M., Trolle, E., and Larnkjaer, A. Skim milk, whey, and casein increase body weight and whey and casein increase the plasma C-peptide concentration in overweight adolescents. J Nutr 2012;142(12):2083-2090. View abstract.

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