Chinese Rhubarb, Da Huang, Garden Rhubarb, Himalayan Rhubarb, Indian Rhubarb, Medicinal Rhubarb, Radix et Rhizoma Rhei, Rewandchini, Rhapontic Rhubarb, Rhei, Rhei Radix, Rheum australe, Rheum emodi, Rheum officinale, Rheum palmatum, Rheum rhaponticum, Rheum tanguticum, Rhubarbe, Rhubarbe de Chine, Rhubarbe Indienne, Rhubarbe Médicinale, Rhubarbe Palmée, Rhubarbe Potagère, Rhubarbe Turque, Ruibarbo, Siberian Rhubarb, Tai Huang, Turkey Rhubarb. <br/><br/>
Overview InformationRhubarb is a plant. The root and underground stem (rhizome) are used to make medicine. The stalk of rhubarb is also consumed as food. Traditional Chinese medicine commonly uses rhubarb alone or in combination with other ingredients.
Rhubarb is used for digestive complaints including constipation, diarrhea, or stomach pain, symptoms of menopause, menstrual cramps (dysmenorrhea), swelling (inflammation) of the pancreas, and many other conditions, but there is no good scientific evidence to support these uses.
In food, rhubarb stems are eaten in pie and other recipes. Rhubarb is also used as a flavoring agent.
How does it work?Rhubarb contains several chemicals which might help heal cold sores and improve movement of the intestines. Some chemicals in rhubarb might reduce swelling. Rhubarb contains fiber that might reduce cholesterol levels.
Uses & Effectiveness
Possibly Effective for
- Canker sores. Some research shows that applying a solution containing rhubarb to canker sores reduces the time it takes for the sores to heal by 3 days. However, it does not seem to be as effective as silver nitrate, a conventional medication.
- Cold sores (herpes labialis). Applying a cream containing rhubarb and sage to herpes cold sores seems to improve healing. It might be as effective as acyclovir (Zovirax) cream.
- Symptoms of menopause. Some research shows that taking a rhubarb root extract by mouth improves symptoms of menopause, including hot flushes, sweating, sleep, mood, quality of life, fatigue, and sexual problems.
- Swelling (inflammation) of the pancreas (pancreatitis). Rhubarb powder given through a tube directly into the intestines might help to reduce pain and other symptoms of pancreatitis. It might also decrease the length of a hospital stay for pancreatitis. Rhubarb might also be helpful for preventing pancreatitis in people who have had a specific type of surgery (endoscopic retrograde cholangiopancreatography, ERCP) that puts them at high risk for pancreatitis.
Insufficient Evidence for
- A sudden and serious lung condition (acute respiratory distress syndrome or ARDS). Early research shows that taking rhubarb daily for 7 days help people with ARDS to breathe better.
- Menstrual cramps (dysmenorrhea). Early research shows that taking rhubarb powder might reduce pain during menstruation.
- Bleeding in the stomach or intestines. There is some evidence that taking rhubarb powder might be useful for treating gastrointestinal (GI) bleeding.
- High cholesterol. Early research shows that eating ground rhubarb stalk for 4 weeks might lower total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol in some people with high cholesterol.
- Long-term kidney disease (chronic kidney disease or CKD). There is not enough reliable information to know if rhubarb helps people with CKD. Some research shows that it might be helpful, but other research shows no benefit. Nearly all of the studies are low quality and at high risk of bias.
- Cancer of the upper part of the throat behind the nose (nasopharyngeal cancer). Early research suggests that taking a specific Chinese herbal product (Shenlong) containing rhubarb and other herbs along with radiation therapy does not improve healing in people with nasopharyngeal cancer.
- Obesity. Some early research shows that taking rhubarb extract 1-3 times daily for up to 3 months might reduce body weight in obese people. However, other research shows that taking rhubarb with other herbs does not reduce weight.
- Pesticide poisoning. Exposure to large amounts of pesticides can result in poisoning. In people with pesticide poisoning, early research suggests that adding rhubarb to regular treatments for poisoning might reduce symptoms and help with recovery.
- Blood infection (sepsis). Early research suggests that using rhubarb along with standard treatments might help reduce the risk for certain complications from sepsis. But rhubarb doesn't seem to reduce the risk of death from sepsis.
- Stroke. Low-quality research suggests that using traditional Chinese medicine that contains rhubarb root and rhizome, in combination with regular stroke treatments, improves function and reduces damage to the brain better than the regular treatments alone in patients who have had a stroke. Higher-quality research is needed to confirm.
- Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD).
- Stomach pain.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: Rhubarb stem is LIKELY SAFE when it is consumed as food. Rhubarb root and rhizome are POSSIBLY SAFE for most adults when taken in medicinal amounts for up to 2 years. Rhubarb stem is POSSIBLY SAFE when taken in medicinal amounts for up to 4 weeks. Rhubarb leaves are POSSIBLY UNSAFE when taken by mouth. Rhubarb leaves contain oxalic acid, which can cause abdominal pain, burning of the mouth and throat, diarrhea, nausea, vomiting, seizures, and death.
Rhubarb leaves are POSSIBLY UNSAFE when taken by mouth. Rhubarb leaves contain oxalic acid, which can cause abdominal pain, burning of the mouth and throat, diarrhea, nausea, vomiting, seizures, and death.
Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm.
There is a report of kidney failure in someone who took a product containing rhubarb. But it's not known for sure if rhubarb was the actual cause of kidney failure.
When applied to the skin: Rhubarb is POSSIBLY SAFE when used for up to 14 days.
Special Precautions & Warnings:Pregnancy and breast-feeding: Rhubarb is POSSIBLY UNSAFE when used in amounts greater than those found in foods.
Diarrhea or constipation: Rhubarb can make diarrhea or constipation worse, depending on the preparation used.
Gastrointestinal (GI) conditions: Don't take rhubarb if you have a bowel obstruction; appendicitis; unexplained stomach pain; or inflammatory conditions of the intestines including Crohn's disease, colitis, and irritable bowel syndrome (IBS).
Kidney disease: There is a chemical in rhubarb that might harm the kidneys. In fact, a supplement that contained rhubarb has been linked to one report of kidney failure. If you already have kidney disease, don't risk making it worse by taking rhubarb.
Kidney stones: Rhubarb contains a chemical that the body can convert into kidney stones. If you have ever had kidney stones, don't take rhubarb.
Liver problems: Rhubarb can make liver function worse in people who already have liver problems. People who have liver problems should avoid rhubarb.
Be cautious with this combination
Digoxin (Lanoxin) interacts with RHUBARB
Rhubarb is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin).
Medications for inflammation (Corticosteroids) interacts with RHUBARB
Some medications for inflammation can decrease potassium in the body. Rhubarb is a type of laxative that might also decrease potassium in the body. Taking rhubarb along with some medications for inflammation might decrease potassium in the body too much.<br/><br/> Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others.
Medications taken by mouth (Oral drugs) interacts with RHUBARB
Rhubarb is a laxative. Laxatives can decrease how much medicine your body absorbs. Decreasing how much medicine your body absorbs can decrease the effectiveness of your medication.
Medications that can harm the kidneys (Nephrotoxic Drugs) interacts with RHUBARB
Taking rhubarb might harm the kidneys in some people. Some medications can also harm the kidneys. Taking rhubarb with medications that can harm the kidneys might increase the chance of kidney damage.<br/><br/> Some of these medications that can harm the kidneys include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.
Stimulant laxatives interacts with RHUBARB
Rhubarb is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels. Taking rhubarb along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body.<br/><br/> Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.
Warfarin (Coumadin) interacts with RHUBARB
Rhubarb can work as a laxative. In some people rhubarb can cause diarrhea. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you take warfarin do not to take excessive amounts of rhubarb.
Water pills (Diuretic drugs) interacts with RHUBARB
Rhubarb is a laxative. Some laxatives can decrease potassium in the body. "Water pills" can also decrease potassium in the body. Taking rhubarb along with "water pills" might decrease potassium in the body too much.<br/><br/> Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.
The following doses have been studied in scientific research:
- For symptoms of menopause: A specific rhubarb root dry extract (ERr 731, Anderson Global Group) 4 mg per day for up to 2 years.
- For swelling (inflammation) of the pancreas (pancreatitis): Rhubarb powder 15 grams in 100 mL warm water given by a healthcare provider through a tube going directly into the small intestine for up to one week.
- For canker sores: A solution containing 5% rhubarb extract applied to the sore one time.
- For cold sores (herpes labialis): Cream containing rhubarb extract 23 mg and sage extract 23 mg in every gram of cream, applied every 2 to 4 hours while awake. Treatment starts within one day after symptoms appear and continues for 10 to 14 days.
- Wei, J., Ni, L., and Yao, J. [Experimental treatment of rhubarb on mesangio-proliferative glomerulonephritis in rats]. Zhonghua Nei Ke.Za Zhi. 1997;36(2):87-89. View abstract.
- Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89. View abstract.
- Xiao-dong Z, An-yu W, Shao-feng W, and et al. Clinical study on effect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal carcinoma. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(4):268-272.
- Xin SF, Zhuang H, Mo QY, and et al. [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. Chinese Journal of Nursing 1995;7(30):420-422.
- Xu, F. and Fu, H. M. [Qing-shen tiao-zhi tablet in the treatment of hyperlipemia in the middle and old aged]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(11):655-7, 643. View abstract.
- Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; View abstract.
- Yang, J. W. and Li, L. S. [Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(5):286-8, 261-2. View abstract.
- Yang, N., Liu, X., and Lin, Q. [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1998;18(12):712-714. View abstract.
- Yarnell E. Rhubarb and diabetic nephropathy. Quarterly Review of Natural Medicine 1997;unlisted:215.
- Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. Effects of rhubarb tannins on renal function in rats with renal failure. Nippon Jinzo Gakkai Shi 1993;35(1):13-18. View abstract.
- Zhang, G. and el Nahas, A. M. The effect of rhubarb extract on experimental renal fibrosis. Nephrol.Dial.Transplant. 1996;11(1):186-190. View abstract.
- Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793. View abstract.
- Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
- Zhang, W. L. [Treatment of hemorrhage of the upper gastro-intestinal tract with the Chinese drug hai huang san. Analysis of 50 cases]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1986;6(11):665-6, 644. View abstract.
- Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. Zhonghua Fu Chan Ke.Za Zhi [Chinese Journal of Obstetrics and Gynecology] 1994;29(8):463-4, 509. View abstract.
- Zheng, F. [Effect of Rheum officinal on the proliferation of renal tubular cells in vitro]. Zhonghua Yi.Xue.Za Zhi. 1993;73(6):343-5, 380-1. View abstract.
- Zhou, H. and Jiao, D. [312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1990;10(3):150-152, 131-132. View abstract.
- Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(4):218-220. View abstract.
- Zhou, Y, Huang, Z, Huang, T, and et al. Clinical study of Shengxue Mixture in treating aplastic anemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189.
- Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579. View abstract.
- Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-130. View abstract.
- Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1994;14(4):230-1, 198. View abstract.
- Kang, Z., Bi, Z., Ji, W., Zhao, C., and Xie, Y. Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. J Tradit.Chin Med 1993;13(4):249-252. View abstract.
- Li, L. Rheum officinale: a new lead in preventing progression of chronic renal failure. Chin Med J (Engl.) 1996;109(1):35-37. View abstract.
- Li, L. S. and Liu, Z. H. [Clinical and experimental studies of rheum on preventing progression of chronic renal failure] (Chinese). Zhong.Xi.Yi.Jie.He.Za Zhi.[Chinese Journal of Modern Developments in Traditional Medicine] 1991;11(7):392-6, 387. View abstract.
- Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1985;5(6):382-384. View abstract.
- Mao QL. Clinical observation on 40 patients with uremia treated by colonic dialysis with rhubarb. Shanxi Journal of Nursing 1997;11(6):262-263.
- Matsuda, H., Tomohiro, N., Hiraba, K., Harima, S., Ko, S., Matsuo, K., Yoshikawa, M., and Kubo, M. Study on anti-Oketsu activity of rhubarb II. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea). Biol Pharm Bull. 2001;24(3):264-267. View abstract.
- Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207. View abstract.
- Oscaby, F. [A chlorhexidine-rhubarb extract mixture for gingival inflammation]. Chir Dent.Fr. 1-30-1992;62(596):23-25. View abstract.
- Peng, S. M., Wang, S. Z., and Zhao, J. P. [Effect of rhubarb on inflammatory cytokines and complements in patients with systemic inflammation reaction syndrome and its significance]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(4):264-266. View abstract.
- Qian GP. [Retention enema with Rheum decoction in treating renal failure]. J.Tradit Chin Med 1980;21(11):18.
- Ren, S. [Role of a virus in hemorrhagic pancreatitis and the therapeutic effect of rhubarb]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1990;10(3):162-3, 133. View abstract.
- Renggli, H. [Gingivitis-and plaque-inhibiting action of Pyralvex Berna and its components]. SSO.Schweiz.Monatsschr.Zahnheilkd. 1980;90(8):718-724. View abstract.
- Sanada, H. [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due to chronic renal failure and its mechanism]. Nippon Jinzo Gakkai Shi 1996;38(8):379-387. View abstract.
- Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. View abstract.
- Sheng, Z. L., Li, N. Y., and Ge, X. P. [Clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(5):268-70, 259. View abstract.
- Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. View abstract.
- Song, H., Wang, Z., and Zhang, F. [Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(2):107-109. View abstract.
- Sun, D. A. [Clinical evaluation of crude rhubarb powder and cimetidine in upper gastrointestinal bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.[Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. View abstract.
- Sun, Y., Chen, B., and Jia, Q. [Clinical effect of Xinqingning combined low dose continuous gastrointestinal dialysis in treating uremia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(9):660-663. View abstract.
- Tian, J., Chen, X. M., and Li, L. S. [Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1991;11(9):547-9, 518. View abstract.
- Tian, J., Du, H., Yang, H., Liu, X., and Li, Z. A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons' memory ability. J Tradit.Chin Med 1997;17(3):168-173. View abstract.
- Wang, Y. J., Xu, L., and Cheng, X. X. [Clinical study on niaodujing in treating chronic renal failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(11):649-651. View abstract.
- Wang, Z. and Song, H. [Clinical observation on therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(12):725-727. View abstract.
- Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(6):364-6, 384. View abstract.
- Zhou, Z. [Application and mechanism of radix et rhizoma rhei in treating diseases of the digestive system]. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. View abstract.
- Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. Am J Chin Med 2005;33(6):839-850. View abstract.
- Zhu, Y. Z., Kang, B., and Zhu, Q. Q. [Clinical study of shuizhi-dahuang mixture in treating schizophrenics with blood stasis syndrome]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(11):646-648. View abstract.
- Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publ, 1997.
- Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. View abstract.
- Greenway FL, Liu Z, Martin CK, et al. Safety and efficacy of NT, an herbal supplement, in treating human obesity. Int J Obes (Lond). 2006;30:1737-41. View abstract.
- Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009 Jan-Feb;16(1):117-31. View abstract.
- He J, Si X, Ji M, et al. Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome. Rev Assoc Med Bras (1992). 2017 May;63(5):435-440. doi: 10.1590/1806-9282.63.05.435. View abstract.
- Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (Err 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59. View abstract.
- Jiao DH, Ma YH, Chen SJ, et al. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-30.
- Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-8. View abstract.
- Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007 Mar-Apr;14(2):270-83. View abstract.
- Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, Beck S, Hasper I, Kravchenko A, Rettenberger R, Richardson A, Heger PW. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health Med. 2009 Jan-Feb;15(1):24-34. View abstract.
- Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7. View abstract.
- Lu L, Li HQ, Fu DL, Zheng GQ, Fan JP. Rhubarb root and rhizome-based Chinese herbal prescriptions for acute ischemic stroke: a systematic review and meta-analysis. Complement Ther Med. 2014 Dec;22(6):1060-70. View abstract.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. View abstract.
- Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9. View abstract.
- Rodríguez-Archilla A, Raissouni T. Randomized clinical trial of the effectiveness of complementary therapies for recurrent aphthous stomatitis. Med Clin (Barc). 2017;149(2):55-60. doi: 10.1016/j.medcli.2016.12.031. View abstract.
- Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. View abstract.
- Tenner S Baillie J, DeWitt J, Vege SS; American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013 Sep;108(9):1400-15; 1416. doi: 10.1038/ajg.2013.218. View abstract.
- Wan B, Fu H, Yin J, Xu F. Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial. Scand J Gastroenterol. 2014 Nov;49(11):1375-84. View abstract.
- Wang H, Song H, Yue J, Li J, Hou YB, Deng JL. Rheum officinale (a traditional Chinese medicine) for chronic kidney disease. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD008000. View abstract.
- Wang L, Pan S. Adjuvant treatment with crude rhubarb for patients with acute organophosphorus pesticide poisoning: A meta-analysis of randomized controlled trials. Complement Ther Med. 2015 Dec;23(6):794-801. View abstract.
- Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. View abstract.
- YX, Zhou XJ, Lv NH.Value of raw rhubarb solution in the precaution of post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with high-risk factors: a predictive random compared research in one center.Wang C, Li Q, Ye P, Zeng S, Li GH, Chen Dig Dis Sci. 2017 Apr;62(4):1043-1050. doi: 10.1007/s10620-017-4464-7. View abstract.
- Zhang L, Chen J, Jiang D, Zhang P. Adjuvant treatment with crude rhubarb for patients with systemic inflammation reaction syndrome/sepsis: a meta-analysis of randomized controlled trials. J Crit Care. 2015 Apr;30(2):282-9. View abstract.
- Zhou Y, Wang L, Huang X, Li H, Xiong Y. Add-on effect of crude rhubarb to somatostatin for acute pancreatitis: A meta-analysis of randomized controlled trials. J Ethnopharmacol. 2016 Dec 24;194:495-505. doi: 10.1016/j.jep.2016.09.053. View abstract.
- Jiao, D. H. [Alcoholic extract tablet of rhubarb in treating acute upper gastrointestinal hemorrhage]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1988;8(6):344-6, 324-5. View abstract.
- Albrecht UW. [The efficacy and tolerability of Pyralvex solution and Pyralvex Gel in the treatment of gingivitis. Results of double-blind, randomised, controlled clinical trials]. Der Freie Zahnarzt 1997;9:76-80.
- Basu TK, Ooraikul B, and Garg M. The lipid-lowering effects of rhubarb stalk fiber: A new source of dietary fiber. Nutrition Reserach 1993;13:1017-1024.
- Bi ZQ, Kang ZQ, and Zheng FL. [Preliminary study of Rheum enema in the treatment of chronic renal failure]. J.Tradit Chin Med 1981;3:211-213.
- Bi, Z. Q. [Nitrogen balance in uremic patients treated with rhubarb retention enema]. Chinese Journal of Modern Developments in Traditional Medicine 1987;7(1):21-3, 4. View abstract.
- Borgia M, Sepe N, Borgia R, and et al. Pharmacological activity of a herbs extract: a controlled clinical study. Curr Ther Res, Clin Exp 1981;29(3):525-536.
- Cai, J., Xuan, Z. R., Wei, Y. P., Yang, H. B., and Wang, H. [Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2005;3(3):195-198. View abstract.
- Chen Q, Han G, Zhuang X, and et al. Clinical observation on 157 subjects of gonorrhea treated with rhubarb preparation. Journal of China Pharmaceutical University 1991;22(5):292-294.
- Chen, X. and Ran, R. [Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis]. Hua Xi.Yi.Ke.Da.Xue.Xue.Bao. 1996;27(4):418-421. View abstract.
- Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., and Lin, Y. Tannins and human health: a review. Crit Rev Food Sci Nutr 1998;38(6):421-464. View abstract.
- Deng, Y. Y., Chen, Y. P., Wang, L., Hu, Z., Jin, Y., Shen, L., Zhu, R., and Zhong, Y. [Clinical study on treatment of mid-advanced crescentic nephritis by qingre huoxue recipe]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(12):1084-1086. View abstract.
- Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380. View abstract.
- Fu, D. C. and Yu, C. Y. [Observation on therapeutic effect of Rhubarb and sanchi powder in treating patients with hemorrhagic fever in nephrotic syndrome complicated with digestive tract bleeding]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(8):744-747. View abstract.
- Goel V, Cheema SK, Agellon LB, and et al. In vitro binding of bile salt to rhubarb stalk powder. Nutrition Research 1998;18(5):893-903.
- Goel, V., Cheema, S. K., Agellon, L. B., Ooraikul, B., and Basu, T. K. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. Br J Nutr 1999;81(1):65-71. View abstract.
- Goel, V., Ooraikul, B., and Basu, T. K. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. J Am Coll.Nutr 1997;16(6):600-604. View abstract.
- Ji, S. M., Li, L. S., and Ji, D. X. [Effects of baoshen pill in treating chronic renal failure with long- term hemodialysis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(2):71-3, 67. View abstract.
- Jiao D, Shen X, Gao Y, and et al. Clinical study on rhubarb extract tablet in treating simple obesity. Chin J Integr Tradit West Med 2001;7(1):33-35.
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