Chinese Rhubarb, Da Huang, Garden Rhubarb, Himalayan Rhubarb, Indian Rhubarb, Medicinal Rhubarb, Radix et Rhizoma Rhei, Rewandchini, Rhapontic Rhubarb, Rhei, Rhei Radix, Rheum australe, Rheum emodi, Rheum officinale, Rheum palmatum, Rheum rhaponticum, Rheum tanguticum, Rhubarbe, Rhubarbe de Chine, Rhubarbe Indienne, Rhubarbe Médicinale, Rhubarbe Palmée, Rhubarbe Potagère, Rhubarbe Turque, Ruibarbo, Siberian Rhubarb, Tai Huang, Turkey Rhubarb. <br/><br/>


Overview Information

Rhubarb is a plant. The root and underground stem (rhizome) are used to make medicine. The stem of rhubarb is also consumed as food. Traditional Chinese medicine commonly uses rhubarb alone or in combination with other ingredients.

Rhubarb is used primarily for digestive complaints including constipation, diarrhea, heartburn, stomach pain, gastrointestinal (GI) bleeding, and preparation for certain GI diagnostic procedures. Some people use rhubarb to decrease the strain during bowel movements. Rhubarb is also used for gonorrhea, high levels of cholesterol in the blood, high blood pressure associated with pregnancy, and weight loss.

Rhubarb is also used to improve symptoms associated with menopause or menstruation. It is also used to reduce pain associated with pancreas swelling (inflammation) or to slow down kidney disease. Rhubarb is used to reduce symptoms of stroke, sepsis (blood infection), or pesticide poisoning. It is also used for some types of cancer and for patients with nonalcoholic fatty liver disease (NAFLD).

A mouth rinse containing rhubarb is used for gingivitis.

Rhubarb is sometimes applied to the skin to treat cold sores.

In food, rhubarb stems are eaten in pie and other recipes. Rhubarb is also used as a flavoring agent.

How does it work?

Rhubarb contains several chemicals which might help heal cold sores and improve movement of the intestines. Some chemicals in rhubarb might reduce swelling. Rhubarb contains fiber that might reduce cholesterol levels.


Uses & Effectiveness?

Possibly Effective for

  • Cold sores. Applying a cream containing rhubarb and sage to herpes cold sores seems to improve healing. It might be as effective as acyclovir (Zovirax) cream.
  • Menopause. Clinical research shows that taking a rhubarb root extract by mouth improves many symptoms of menopause, including hot flushes, sweating, sleep, mood, quality of life, fatigue, and sexual problems.
  • Pancreas inflammation (pancreatitis). Rhubarb powder given through a tube directly into the intestines might help to reduce pain and other symptoms of pancreatitis. It might also decrease the length of a hospital stay for pancreatitis.

Insufficient Evidence for

  • Painful menstruation (dysmenorrhea). Early research suggests that taking rhubarb powder might reduce pain during menstruation.
  • Bleeding from the stomach and bowels. There is some evidence that taking rhubarb powder might be useful for treating gastrointestinal (GI) bleeding.
  • High cholesterol. Early research shows that eating ground rhubarb stalk for 4 weeks can lower total cholesterol and low-density lipoprotein (LDL or "bad") cholesterol in people with high cholesterol.
  • Kidney disease. There is not enough reliable information to know if rhubarb helps people with kidney disease. Most studies have measured the effects of rhubarb on markers of kidney disease and the progression of kidney disease to kidney failure. Results are conflicting. Nearly all of the studies are low quality and at high risk of bias.
  • Cancer affecting the area behind the nose (nasopharyngeal cancer). Early research suggests that taking a specific Chinese herbal product (Shenlong) containing rhubarb and other herbs along with radiation therapy does not improve healing in people with nasopharyngeal cancer.
  • Nonalcoholic fatty liver disease (NAFLD). Early research suggests that taking a specific Chinese herbal medicine (Danning Pian) containing rhubarb, giant knotweed, dried green orange peel, and dried old orange peel might improve liver function in people with non-alcoholic fatty liver disease. It's unknown if rhubarb helps if taken by itself.
  • Obesity. Some early research suggests that taking rhubarb extract 1-3 times daily for up to 3 months might reduce body weight in obese people. However, other research shows that taking rhubarb with other herbs does not reduce weight.
  • Poisoning. Exposure to large amounts of pesticides can result in poisoning. In people with pesticide poisoning, early research suggests that taking rhubarb or having rhubarb placed in the rectum as an enema, while also using regular treatments for poisoning, might reduce symptoms and maintain the function of the body.
  • Life-threatening infection (sepsis). Early research suggests that using rhubarb along with standard treatments might help reduce the risk for certain complications from a life-threatening infection called sepsis. But rhubarb doesn't appear to reduce death due to this type of infection.
  • Stroke. Low-quality research suggests that using traditional Chinese medicine that contains rhubarb root and rhizome, in combination with regular stroke treatments, improves function and reduces damage to the brain better than the regular treatments alone in patients who have had a stroke. Higher-quality research is needed to confirm.
  • Diarrhea.
  • Hemorrhoids.
  • Indigestion.
  • Stomach pain.
  • Other conditions.
More evidence is needed to rate the effectiveness of rhubarb for these uses.

Side Effects

Side Effects & Safety

Rhubarb stem is LIKELY SAFE when it is consumed as food. Rhubarb root and rhizome are POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 2 years. Rhubarb stem is POSSIBLY SAFE when taken by mouth in medicinal amounts for up to 4 weeks.

Rhubarb leaves are POSSIBLY UNSAFE when taken by mouth. Rhubarb leaves contain oxalic acid, which can cause abdominal pain, burning of the mouth and throat, diarrhea, nausea, vomiting, seizures, and death.

Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, nausea, vomiting, rash, and uterine contractions. Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm.

There is a report of kidney failure in someone who took a product containing rhubarb. But it's not known for sure if rhubarb was the actual cause of kidney failure.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Rhubarb is POSSIBLY UNSAFE when used in amounts greater than those found in foods.

Diarrhea or constipation: Rhubarb can make diarrhea or constipation worse, depending on the preparation used.

Gastrointestinal (GI) conditions: Don't take rhubarb if you have a bowel obstruction; appendicitis; unexplained stomach pain; or inflammatory conditions of the intestines including Crohn's disease, colitis, and irritable bowel syndrome (IBS).

Kidney disease: There is a chemical in rhubarb that might harm the kidneys. In fact, a supplement that contained rhubarb has been linked to one report of kidney failure. If you already have kidney disease, don't risk making it worse by taking rhubarb.

Kidney stones: Rhubarb contains a chemical that the body can convert into kidney stones. If you have ever had kidney stones, don't take rhubarb.

Liver problems: Rhubarb can make liver function worse in people who already have liver problems. People who have liver problems should avoid rhubarb.



Moderate Interaction

Be cautious with this combination

  • Digoxin (Lanoxin) interacts with RHUBARB

    Rhubarb is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin).

  • Medications for inflammation (Corticosteroids) interacts with RHUBARB

    Some medications for inflammation can decrease potassium in the body. Rhubarb is a type of laxative that might also decrease potassium in the body. Taking rhubarb along with some medications for inflammation might decrease potassium in the body too much.<br/><br/> Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others.

  • Medications taken by mouth (Oral drugs) interacts with RHUBARB

    Rhubarb is a laxative. Laxatives can decrease how much medicine your body absorbs. Decreasing how much medicine your body absorbs can decrease the effectiveness of your medication.

  • Medications that can harm the kidneys (Nephrotoxic Drugs) interacts with RHUBARB

    Taking rhubarb might harm the kidneys in some people. Some medications can also harm the kidneys. Taking rhubarb with medications that can harm the kidneys might increase the chance of kidney damage.<br/><br/> Some of these medications that can harm the kidneys include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

  • Stimulant laxatives interacts with RHUBARB

    Rhubarb is a type of laxative called a stimulant laxative. Stimulant laxatives speed up the bowels. Taking rhubarb along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body.<br/><br/> Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.

  • Warfarin (Coumadin) interacts with RHUBARB

    Rhubarb can work as a laxative. In some people rhubarb can cause diarrhea. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you take warfarin do not to take excessive amounts of rhubarb.

  • Water pills (Diuretic drugs) interacts with RHUBARB

    Rhubarb is a laxative. Some laxatives can decrease potassium in the body. "Water pills" can also decrease potassium in the body. Taking rhubarb along with "water pills" might decrease potassium in the body too much.<br/><br/> Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.



The following doses have been studied in scientific research:


  • For menopause: A specific rhubarb root dry extract (ERr 731, Anderson Global Group) ) 4 mg per day for up to 2 years.
  • For swelling of the pancreas (pancreatitis): Rhubarb powder 15 grams in 100 mL warm water given by a healthcare provider through a tube going directly into the small intestine for up to one week.
  • For cold sores: Cream containing rhubarb extract 23 mg and sage extract 23 mg in every gram of cream, applied every 2 to 4 hours while awake. Treatment starts within one day after symptoms appear and continues for 10 to 14 days.

View References


  • Barker, B. E. and Farnes, P. Histochemistry of blood cells treated with pokeweed mitogen. Nature 5-20-1967;214(90):787-789. View abstract.
  • Barker, B. E., Farnes, P., and LaMarche, P. H. Peripheral blood plasmacytosis following systemic exposure to Phytolacca americana (pokweed). Pediatrics 1966;38(3):490-493. View abstract.
  • Barkhordari, A., Stoddart, R. W., McClure, S. F., and McClure, J. Lectin histochemistry of normal human lung. J Mol.Histol. 2004;35(2):147-156. View abstract.
  • Basham, T. Y., Toyoshima, S., Finkelman, F., and Waxdal, M. J. A series of murine interleukin molecules which stimulate both murine and human lymphocytes. I. Production by Phytolacca americana (pokeweed) lectin 2 (Pa-2)-stimulated thymus and thymus-derived cells. Cell Immunol. 9-1-1981;63(1):118-133. View abstract.
  • Bjorn, M. J., Larrick, J., Piatak, M., and Wilson, K. J. Characterization of translational inhibitors from Phytolacca americana. Amino-terminal sequence determination and antibody-inhibitor conjugates. Biochim.Biophys.Acta 10-23-1984;790(2):154-163. View abstract.
  • Bodger, M. P., McGiven, A. R., and Fitzgerald, P. H. Mitogenic proteins of pokeweed. II. The differentiation of human peripheral blood B lymphocytes stimulated with purified pokeweed mitogens (Po-2 and Po-6) from pokeweed, Phytolacca octandra. Immunology 1979;37(4):793-799. View abstract.
  • Cho, S. Y., Sim, J. S., Kang, S. S., Jeong, C. S., Linhardt, R. J., and Kim, Y. S. Enhancement of heparin and heparin disaccharide absorption by the Phytolacca americana saponins. Arch Pharm Res 2003;26(12):1102-1108. View abstract.
  • Chu, J. Y., Yang, A. D., Wang, B. M., Hu, Z., Zhu, X. M., Zhang, H. J., Qu, J. H., Luo, L. Y., Guo, R., and Shi, L. R. Monoclonal anti-human T cell antibody and PAP-s conjugate--preparation and selective cytotoxic properties on leukemic cell. J Tongji Med Univ 1990;10(1):15-18. View abstract.
  • D'Cruz, O. J. and Uckun, F. M. Pokeweed antiviral protein: a potential nonspermicidal prophylactic antiviral agent. Fertil.Steril. 2001;75(1):106-114. View abstract.
  • D'Cruz, O. J., Waurzyniak, B., and Uckun, F. M. Mucosal toxicity studies of a gel formulation of native pokeweed antiviral protein. Toxicol.Pathol. 2004;32(2):212-221. View abstract.
  • Erko, B., Abebe, F., Berhe, N., Medhin, G., Gebre-Michael, T., Gemetchu, T., and Gundersen, S. G. Control of Schistosoma mansoni by the soapberry Endod (Phytolacca dodecandra) in Wollo, northeastern Ethiopia: post-intervention prevalence. East Afr.Med J 2002;79(4):198-201. View abstract.
  • Evans, G. S., Chwalinski, S., Owen, G., Booth, C., Singh, A., and Potten, C. S. Expression of pokeweed lectin binding in murine intestinal Paneth cells. Epithelial Cell Biol 1994;3(1):7-15. View abstract.
  • Fedder, J. and Ellerman-Eriksen, S. Effect of cytokines on sperm motility and ionophore-stimulated acrosome reaction. Arch Androl 1995;35(3):173-185. View abstract.
  • Goll, P. H., Lemma, A., Duncan, J., and Mazengia, B. Control of schistosomiasis in Adwa, Ethiopia, using the plant molluscicide endod (Phytolacca dodecandra). Tropenmed.Parasitol. 1983;34(3):177-183. View abstract.
  • Hamilton, R. J., Shih, R. D., and Hoffman, R. S. Mobitz type I heart block after pokeweed ingestion. Vet.Hum Toxicol. 1995;37(1):66-67. View abstract.
  • Holstege, C. P., Miller, M. B., Wermuth, M., Furbee, B., and Curry, S. C. Crotalid snake envenomation. Crit Care Clin 1997;13(4):889-921. View abstract.
  • Hostettmann, K. On the use of plants and plant-derived compounds for the control of schistosomiasis. Naturwissenschaften 1984;71(5):247-251. View abstract.
  • Kell, SO, Rosenberg, SA, Conlon, TJ, and Spyker, DA. A peek at poke: Mitogenicity and epidemiology. Vet.Hum Toxicol. 1982;24(4):36.
  • Kino, M., Yamaguchi, K., Umekawa, H., and Funatsu, G. Purification and characterization of three mitogenic lectins from the roots of pokeweed (Phytolacca americana). Biosci.Biotechnol.Biochem. 1995;59(4):683-688. View abstract.
  • Lemma, A. Laboratory and field evaluation of the molluscicidal properties of Phytolacca dodecandra. Bull World Health Organ 1970;42(4):597-612. View abstract.
  • Lenghel, V., Radu, D. L., Chirila, P., and Olinescu, A. The influence of some vegetable extracts on the in vitro adherence of mouse and human lymphocytes to nylon fibers. Roum.Arch Microbiol.Immunol 1995;54(1-2):15-30. View abstract.
  • Brinker F. Herb Contraindications and Drug Interactions. Sandy, OR: Eclectic Medical Publ, 1997.
  • Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. View abstract.
  • Greenway FL, Liu Z, Martin CK, et al. Safety and efficacy of NT, an herbal supplement, in treating human obesity. Int J Obes (Lond). 2006;30:1737-41. View abstract.
  • Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009 Jan-Feb;16(1):117-31. View abstract.
  • Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (Err 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59. View abstract.
  • Jiao DH, Ma YH, Chen SJ, et al. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-30.
  • Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-8. View abstract.
  • Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007 Mar-Apr;14(2):270-83. View abstract.
  • Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, Beck S, Hasper I, Kravchenko A, Rettenberger R, Richardson A, Heger PW. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health Med. 2009 Jan-Feb;15(1):24-34. View abstract.
  • Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7. View abstract.
  • Lu L, Li HQ, Fu DL, Zheng GQ, Fan JP. Rhubarb root and rhizome-based Chinese herbal prescriptions for acute ischemic stroke: a systematic review and meta-analysis. Complement Ther Med. 2014 Dec;22(6):1060-70. View abstract.
  • Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. View abstract.
  • Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9. View abstract.
  • Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. View abstract.
  • Wan B, Fu H, Yin J, Xu F. Efficacy of rhubarb combined with early enteral nutrition for the treatment of severe acute pancreatitis: a randomized controlled trial. Scand J Gastroenterol. 2014 Nov;49(11):1375-84. View abstract.
  • Wang H, Song H, Yue J, Li J, Hou YB, Deng JL. Rheum officinale (a traditional Chinese medicine) for chronic kidney disease. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD008000. View abstract.
  • Abad, M. J., Bermejo, P., Sanchez, Palomino S., Chiriboga, X., and Carrasco, L. Antiviral activity of some South American medicinal plants. Phytother Res 1999;13(2):142-146. View abstract.
  • Baalawy, S. S. Laboratory evaluation of the molluscicidal potency of a butanol extract of Phytolacca dodecandra (endod) berries. Bull World Health Organ 1972;47(3):422-425. View abstract.
  • Tian, J., Chen, X. M., and Li, L. S. [Effects of Cordyceps sinensis, rhubarb and serum renotropin on tubular epithelial cell growth]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1991;11(9):547-9, 518. View abstract.
  • Tian, J., Du, H., Yang, H., Liu, X., and Li, Z. A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons' memory ability. J Tradit.Chin Med 1997;17(3):168-173. View abstract.
  • Wang, Y. J., Xu, L., and Cheng, X. X. [Clinical study on niaodujing in treating chronic renal failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(11):649-651. View abstract.
  • Wang, Z. and Song, H. [Clinical observation on therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(12):725-727. View abstract.
  • Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(6):364-6, 384. View abstract.
  • Wei, J., Ni, L., and Yao, J. [Experimental treatment of rhubarb on mesangio-proliferative glomerulonephritis in rats]. Zhonghua Nei Ke.Za Zhi. 1997;36(2):87-89. View abstract.
  • Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89. View abstract.
  • Xiao-dong Z, An-yu W, Shao-feng W, and et al. Clinical study on effect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal carcinoma. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(4):268-272.
  • Xin SF, Zhuang H, Mo QY, and et al. [Clinical observation on patients with constipation using Rhubarb and Mangxiao]. Chinese Journal of Nursing 1995;7(30):420-422.
  • Xu, F. and Fu, H. M. [Qing-shen tiao-zhi tablet in the treatment of hyperlipemia in the middle and old aged]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(11):655-7, 643. View abstract.
  • Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; View abstract.
  • Yang, J. W. and Li, L. S. [Effects of Rheum on renal hypertrophy and hyperfiltration of experimental diabetes in rat]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(5):286-8, 261-2. View abstract.
  • Yang, N., Liu, X., and Lin, Q. [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1998;18(12):712-714. View abstract.
  • Yarnell E. Rhubarb and diabetic nephropathy. Quarterly Review of Natural Medicine 1997;unlisted:215.
  • Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. Effects of rhubarb tannins on renal function in rats with renal failure. Nippon Jinzo Gakkai Shi 1993;35(1):13-18. View abstract.
  • Zhang, G. and el Nahas, A. M. The effect of rhubarb extract on experimental renal fibrosis. Nephrol.Dial.Transplant. 1996;11(1):186-190. View abstract.
  • Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793. View abstract.
  • Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
  • Zhang, W. L. [Treatment of hemorrhage of the upper gastro-intestinal tract with the Chinese drug hai huang san. Analysis of 50 cases]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1986;6(11):665-6, 644. View abstract.
  • Zhang, Z. J., Cheng, W. W., and Yang, Y. M. [Low-dose of processed rhubarb in preventing pregnancy induced hypertension]. Zhonghua Fu Chan Ke.Za Zhi [Chinese Journal of Obstetrics and Gynecology] 1994;29(8):463-4, 509. View abstract.
  • Zheng, F. [Effect of Rheum officinal on the proliferation of renal tubular cells in vitro]. Zhonghua Yi.Xue.Za Zhi. 1993;73(6):343-5, 380-1. View abstract.
  • Zhou, H. and Jiao, D. [312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1990;10(3):150-152, 131-132. View abstract.
  • Zhou, L., Hao, R., and Jiang, L. [Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(4):218-220. View abstract.
  • Zhou, Y, Huang, Z, Huang, T, and et al. Clinical study of Shengxue Mixture in treating aplastic anemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189.
  • Zhou, Z. [Application and mechanism of radix et rhizoma rhei in treating diseases of the digestive system]. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. View abstract.
  • Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. Am J Chin Med 2005;33(6):839-850. View abstract.
  • Zhu, Y. Z., Kang, B., and Zhu, Q. Q. [Clinical study of shuizhi-dahuang mixture in treating schizophrenics with blood stasis syndrome]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(11):646-648. View abstract.
  • Lewis, W. H. and Smith, P. R. Poke root herbal tea poisoning. JAMA 12-21-1979;242(25):2759-2760. View abstract.
  • Lozovoi, V. P., Kiselev, S. V., and Kotenev, V. M. [A system of assessing interleukin-2-dependent activation of B-lymphocytes]. Lab Delo 1989;(7):60-62. View abstract.
  • Mir, L. M., Banoun, H., and Paoletti, C. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp Cell Res 1988;175(1):15-25. View abstract.
  • Morgan, A. C., Jr., Bordonaro, J., Pearson, J. W., and Sivam, G. Immunotoxins to a human melanoma-associated antigen: resistance to pokeweed antiviral protein conjugates in vitro. J Natl.Cancer Inst. 1987;78(6):1101-1106. View abstract.
  • Ndekha, A., Hansen, E. H., Molgaard, P., Woelk, G., and Furu, P. Community participation as an interactive learning process: experiences from a schistosomiasis control project in Zimbabwe. Acta Trop. 2003;85(3):325-338. View abstract.
  • Rajamohan, F., Venkatachalam, T. K., Irvin, J. D., and Uckun, F. M. Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1. Biochem.Biophys.Res Commun. 7-5-1999;260(2):453-458. View abstract.
  • Rau, E. Treatment of acute tonsillitis with a fixed-combination herbal preparation. Adv.Ther. 2000;17(4):197-203. View abstract.
  • Schlick, J., Dulieu, P., Desvoyes, B., Adami, P., Radom, J., and Jouvenot, M. Cytotoxic activity of a recombinant GnRH-PAP fusion toxin on human tumor cell lines. FEBS Lett. 4-28-2000;472(2-3):241-246. View abstract.
  • Stolzenberg, S. J. and Parkhurst, R. M. Spermicidal actions of extracts and compounds from Phytolacca dodecandra. Contraception 1974;10(2):135-143. View abstract.
  • Sussner, U., Abel, G., Schulte, R., and Kreis, W. Isolation and characterisation of a cysteine protease (phytolacain G), from Phytolacca americana roots. Planta Med 2004;70(10):942-947. View abstract.
  • Tachibana, Y., Kato, A., Nishiyama, Y., Kawanishi, K., Tobe, H., Juma, F. D., Ogeto, J. O., and Mathenge, S. G. Mitogenic activities in African traditional herbal medicines. Planta Med 1993;59(4):354-358. View abstract.
  • Treyvaud, V., Marston, A., Dyatmiko, W., and Hostettmann, K. Molluscicidal saponins from Phytolacca icosandra. Phytochemistry 2000;55(6):603-609. View abstract.
  • Wang L, Pan S. Adjuvant treatment with crude rhubarb for patients with acute organophosphorus pesticide poisoning: A meta-analysis of randomized controlled trials. Complement Ther Med. 2015 Dec;23(6):794-801. View abstract.
  • Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. View abstract.
  • Zhang L, Chen J, Jiang D, Zhang P. Adjuvant treatment with crude rhubarb for patients with systemic inflammation reaction syndrome/sepsis: a meta-analysis of randomized controlled trials. J Crit Care. 2015 Apr;30(2):282-9. View abstract.

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