Inositol nicotinate is used for blood circulation problems, including a painful response to cold, especially in the fingers and toes (Raynaud syndrome). It is also used for high cholesterol, high blood pressure, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Possibly Effective for
- Painful response to cold especially in the fingers and toes (Raynaud syndrome). Some research shows that taking a specific product of inositol nicotinate (Hexopal) by mouth for several weeks modestly improves symptoms of Raynaud syndrome.
Insufficient Evidence for
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). The effectiveness of inositol nicotinate for treating high cholesterol is unclear. Some research shows that inositol nicotinate can decrease cholesterol levels. But other research shows that inositol nicotinate does not have an effect.
- Leg pain during exercise due to poor blood flow (intermittent claudication). The effectiveness of inositol nicotinate for treating intermittent claudication is unclear. Some research shows that taking a specific inositol nicotinate product (Hexopal) by mouth for up to 3 months improves walking distance and reduces symptoms. But other research does not show this effect.
- Blood disorders of the brain.
- Migraine headache.
- Hardened skin (scleroderma).
- High blood pressure.
- A disorder that causes leg discomfort and an irresistible urge to move the legs (restless legs syndrome or RLS).
- Inflammation of the tongue (exfoliative glossitis).
- Other conditions.
Some inositol nicotinate products are promoted as "no-flush" niacin because some people think they don't cause as much flushing as regular niacin. But this possible benefit has not been proven in research studies.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if inositol nicotinate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Allergies: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, might make allergies worse by releasing histamine. This is the chemical that triggers allergy symptoms.
Bleeding disorder: Inositol nicotinate might slow blood clotting. In theory, inositol nicotinate might increase the risk of bleeding and make bleeding disorders worse.
Heart disease/heart-related chest pain (unstable angina): Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, can increase the risk of irregular heartbeat. If you have a heart condition, check with your healthcare provider before using inositol nicotinate.
Diabetes: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can interfere with blood sugar control. This might require an adjustment in the dose of medicines needed to control diabetes. Increased blood sugar monitoring may be necessary, particularly at the beginning of treatment. If you have diabetes, check with your healthcare provider before using inositol nicotinate.
Gallbladder disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, might make gallbladder problems worse. Use with caution.
Gout: Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, might trigger gout. Use with caution.
Low blood pressure: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause low blood pressure. Use with caution.
Kidney disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, might accumulate in people with kidney disease and make their condition worse. Don't use inositol nicotinate if you have kidney problems.
Liver disease: Niacin, a chemical that is released when inositol nicotinate breaks down in the body, can cause liver damage. Don't use inositol nicotinate if you have liver disease.
Sensitivity to niacin: Niacin is released when inositol nicotinate is processed by the body. If you are sensitive to niacin, don't use inositol nicotinate.
Stomach ulcers: Large amounts of niacin, a chemical that is released when inositol nicotinate breaks down in the body, might make peptic ulcer disease worse. Don't use inositol nicotinate if you have ulcers.
Surgery: Inositol nicotinate might slow blood clotting. There is some concern that it might increase the risk of bleeding during and after surgery. Stop taking inositol nicotinate at least 2 weeks before a scheduled surgery.
Special Precautions and Warnings
We currently have no information for INOSITOL NICOTINATE overview.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with INOSITOL NICOTINATE
Inositol nicotinate might slow blood clotting. Taking inositol nicotinate along with medications that also slow clotting might increase the chances of bruising and bleeding. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Medications used for lowering cholesterol (Statins) interacts with INOSITOL NICOTINATE
Inositol nicotinate is changed in the body to niacin. Niacin can affect the muscles. Some medication used for lowering cholesterol can also affect the muscles. Taking niacin along with some medications used for lowering high cholesterol might increase the risk of muscle problems.
Some medications used for high cholesterol include cerivastatin (Baycol), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and others.
Medications for diabetes (Antidiabetes drugs) interacts with INOSITOL NICOTINATE
Chronic use of inositol nicotinate might increase blood sugar. Diabetes medications are used to lower blood sugar. By increasing blood sugar, inositol nicotinate might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Nicotine patch (Transdermal nicotine) interacts with INOSITOL NICOTINATE
Inositol nicotinate is broken down in the body to niacin. Niacin can sometimes cause flushing and dizziness. The nicotine patch can also cause flushing and dizziness. Taking inositol nicotinate and using a nicotine patch can increase the possibility of becoming flushed and dizzy.
Be cautious with this combination
- General: Some dietary supplement products might not list inositol nicotinate separately on the label. Instead, it might be listed under niacin. Niacin is measured in niacin equivalents (NE). 1 mg of inositol nicotinate is the same as 1 mg NE.
- Painful response to cold especially in the fingers and toes (Raynaud syndrome): 4 grams daily has been used. It might take several weeks before effects are seen.
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