ROSE HIP
Apothecary Rose, Cynorhodon, Cynorhodons, Cynosbatos, Dog Rose, Dog Rose Hips, Églantier, Fruit de l'Églantier, Gulab, Heps, Hip, Hip Fruit, Hip Sweet, Hipberry, Hop Fruit, Persian Rose, Phool Gulab, Pink Rose, Poire d'oiseaux, Rosa alba, Rosa canina, Rosa centifolia, Rosa damascena, Rosa de Castillo, Rosa gallica, Rosa lutetiana, Rosa Mosqueta, Rosa pomifera, Rosa provincialis, Rosa rugosa, Rosa villosa, Rosae Pseudofructus Cum Semen, Rose de Provins, Rose des Apothicaires, Rose Hips, Rose Rouge de Lancaster, Rosehip, Rosehips, Rosier de Provence, Satapatri, Satapatrika, Shatpari, Wild Boar Fruit.<br/><br/>
Uses & Effectiveness
Possibly Effective for
- Osteoarthritis. Most research shows that taking a specific rose hip product (LitoZin/i-flex, Hyben Vital) by mouth twice daily for 3-4 months reduces pain and stiffness and improves function in people with osteoarthritis.
Insufficient Evidence for
- Obesity. Early research shows that taking rose hip powder mixed with apple juice does not affect weight or blood sugar levels in people who are obese. But it might slightly reduce cholesterol and blood pressure.
- Rheumatoid arthritis. Early research shows that taking a specific rose hip product (LitoZin/i-flex, Hyben Vital) by mouth improves some symptoms of rheumatoid arthritis.
- Stretch marks (striae gravidarum). Early research shows that applying a specific cream containing rose hip oil and other ingredients (Velastisa Antiestrías, ISDIN) to the skin at least twice daily during pregnancy reduces the severity of stretch marks. It also might reduce the chance of getting stretch marks in women who didn't have stretch marks before becoming pregnant.
- Boosting the immune system.
- Diarrhea.
- Fever.
- Infections.
- Preventing and treating colds.
- Stomach irritations.
- Other conditions.
Side Effects & Safety
Rose hip is LIKELY SAFE for adults when taken by mouth appropriately. Rose hip can cause some side effects such as nausea, vomiting, diarrhea, constipation, heartburn, stomach cramps, fatigue, headache, inability to sleep, and others.There is not enough reliable information about the safety of applying rose hip to the skin.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking rose hip by mouth as a medicine during pregnancy or breast feeding. Stay on the safe side and avoid using amounts larger than those found in food. There is also not enough reliable information about the safety of rose hip when applied to the skin during pregnancy or breast feeding.Diabetes: The vitamin C in rose hip might affect the control of diabetes, but not all experts agree on this.
Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency): Large amounts of the vitamin C in rose hip might increase the risk of complications.
Kidney stones: Large amounts of the vitamin C in rose hip might increase the chance of getting kidney stones.
Iron-related disorders such as hemochromatosis, thalassemia, or anemia: Use rose hip with caution if you have any of these conditions. The vitamin C in rose hip can increase iron absorption, which could make your condition worse.
Heart attack (myocardial infarction): Rose hip contains rugosin E. Rugosin E might cause blood clots. If you've had a heart attack, taking rose hip might increase the chance of blood clots or another heart attack.
Sickle cell disease: It is rare, but the vitamin C in rose hip might make blood more acidic. This could bring on a sickle cell crisis. It's best to avoid use.
Stroke: Rose hip contains rugosin E. Rugosin E might cause blood clots. If you've had a stroke, taking rose hip might increase the chance of blood clots or another stroke.
Blood clots in legs (deep vein thrombosis) or lungs (pulmonary embolism): Rose hip contains rugosin E. Rugosin E might cause blood clots. If you've had blood clots in your legs or lungs before, taking rose hip might increase the chance of another clot.
Interactions
Moderate Interaction
Be cautious with this combination
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Aluminum interacts with ROSE HIP
Aluminum is found in most antacids. Rose hips contain vitamin C. Vitamin C can increase how much aluminum the body absorbs. But it isn't clear if this interaction is a big concern. Take rose hip two hours before or four hours after antacids.
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Estrogens interacts with ROSE HIP
Rose hip contains a large amount of vitamin C. Vitamin C can increase how much estrogen the body absorbs. Taking rose hip along with estrogen can increase the effects and side effects of estrogens.<br/><br/> Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
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Fluphenazine (Prolixin) interacts with ROSE HIP
Rose hip contains vitamin C. Large amounts of vitamin C might increase how quickly the body gets rid of fluphenazine (Prolixin). Taking rose hip along with fluphenazine (Prolixin) might decrease the effectiveness of fluphenazine (Prolixin).
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Lithium interacts with ROSE HIP
Rose hip might have an effect like a water pill or "diuretic." Taking rose hip might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
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Warfarin (Coumadin) interacts with ROSE HIP
Warfarin (Coumadin) is used to slow blood clotting. Rose hip contains vitamin C. Large amounts of vitamin C might decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Minor Interaction
Be watchful with this combination
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Aspirin interacts with ROSE HIP
The body breaks down aspirin to get rid of it. Rose hip contains large amounts of vitamin C. Large amounts of vitamin C might decrease the breakdown of aspirin. Taking large amount of rose hip along with aspirin might increase the effects and side effects of aspirin. Do not take large amounts of vitamin C if you take large amounts of aspirin.
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Choline Magnesium Trisalicylate (Trilisate) interacts with ROSE HIP
Rose hip contains vitamin C. Vitamin C might decrease how quickly the body gets rid of choline magnesium trisalicylate (Trilisate). But it is not clear if this interaction is a big concern.
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Salsalate (Disalcid) interacts with ROSE HIP
Rose hip contains vitamin C. Vitamin C might decrease how quickly the body gets rid of salsalate (Disalcid). Taking rose hip along with salsalate (Disalcid) might increase the effects and side effects of salsalate.
Dosing
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- For osteoarthritis: Five capsules containing a total of 2.5 grams of rose hip powder (LitoZin/i-flex, Hyben Vital) has been taken twice daily for 3 months.
REFERENCES:
- Basim, E. and Basim, H. Antibacterial activity of Rosa damascena essential oil. Fitoterapia 2003;74(4):394-396. View abstract.
- Biswas, N. R., Gupta, S. K., Das, G. K., Kumar, N., Mongre, P. K., Haldar, D., and Beri, S. Evaluation of Ophthacare eye drops--a herbal formulation in the management of various ophthalmic disorders. Phytother.Res. 2001;15(7):618-620. View abstract.
- Cho, E. J., Yokozawa, T., Rhyu, D. Y., Kim, S. C., Shibahara, N., and Park, J. C. Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical. Phytomedicine. 2003;10(6-7):544-551. View abstract.
- Chrubasik, C., Duke, R. K., and Chrubasik, S. The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res 2006;20(1):1-3. View abstract.
- Daels-Rakotoarison, D. A., Gressier, B., Trotin, F., Brunet, C., Luyckx, M., Dine, T., Bailleul, F., Cazin, M., and Cazin, J. C. Effects of Rosa canina fruit extract on neutrophil respiratory burst. Phytother.Res. 2002;16(2):157-161. View abstract.
- Dushkin, M. I., Zykov, A. A., and Pivovarova, E. N. [The effect of natural polyphenol compounds on the oxidative modification of low-density lipoproteins]. Biull.Eksp.Biol Med 1993;116(10):393-395. View abstract.
- Hornero-Mendez, D. and Minguez-Mosquera, M. I. Carotenoid pigments in Rosa mosqueta hips, an alternative carotenoid source for foods. J Agric Food Chem 2000;48(3):825-828. View abstract.
- Janse, van Rensburg, Erasmus, E., Loots, D. T., Oosthuizen, W., Jerling, J. C., Kruger, H. S., Louw, R., Brits, M., and van der Westhuizen, F. H. Rosa roxburghii supplementation in a controlled feeding study increases plasma antioxidant capacity and glutathione redox state. Eur J Nutr 2005;44(7):452-457. View abstract.
- Kumarasamy, Y., Cox, P. J., Jaspars, M., Nahar, L., and Sarker, S. D. Screening seeds of Scottish plants for antibacterial activity. J Ethnopharmacol 2002;83(1-2):73-77. View abstract.
- Larsen, E., Kharazmi, A., Christensen, L. P., and Christensen, S. B. An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J.Nat.Prod. 2003;66(7):994-995. View abstract.
- Ma, Y. X., Zhu, Y., Wang, C. F., Wang, Z. S., Chen, S. Y., Shen, M. H., Gan, J. M., Zhang, J. G., Gu, Q., and He, L. The aging retarding effect of 'Long-Life CiLi'. Mech.Ageing Dev 1997;96(1-3):171-180. View abstract.
- Moreno Gimenez, J. C., Bueno, J., Navas, J., and Camacho, F. [Treatment of skin ulcer using oil of mosqueta rose]. Med Cutan.Ibero.Lat.Am 1990;18(1):63-66. View abstract.
- Rein, E., Kharazmi, A., and Winther, K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis--a double-blind, placebo-controlled, randomised trial. Phytomedicine. 2004;11(5):383-391. View abstract.
- Rein, E., Kharazmi, A., Thamsborg, G., and Winther, K. Herbal remedy made from a subspecies of rose-hip Rosa canina reduces symptoms of knee and hip osteoarthritis. Osteoarthr Cartil 2004;12(Suppl 2):80.
- Rossnagel, K. and Willich, S. N. [Value of complementary medicine exemplified by rose-hips]. Gesundheitswesen 2001;63(6):412-416. View abstract.
- Shabykin, G. P. and Godorazhi, A. I. [A polyvitamin preparation of fat-soluble vitamins (carotolin) and rose hip oil in the treatment of certain dermatoses]. Vestn.Dermatol.Venerol. 1967;41(4):71-73. View abstract.
- Shiota, S., Shimizu, M., Mizusima, T., Ito, H., Hatano, T., Yoshida, T., and Tsuchiya, T. Restoration of effectiveness of beta-lactams on methicillin-resistant Staphylococcus aureus by tellimagrandin I from rose red. FEMS Microbiol.Lett 4-15-2000;185(2):135-138. View abstract.
- Teng, C. M., Kang, Y. F., Chang, Y. L., Ko, F. N., Yang, S. C., and Hsu, F. L. ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. Thromb.Haemost. 1997;77(3):555-561. View abstract.
- Trovato, A., Monforte, M. T., Forestieri, A. M., and Pizzimenti, F. In vitro anti-mycotic activity of some medicinal plants containing flavonoids. Boll Chim Farm 2000;139(5):225-227. View abstract.
- Venkatesh, R. P., Ramaesh, K., and Browne, B. Rose-hip keratitis. Eye 2005;19(5):595-596. View abstract.
- Warholm, O., Skaar, S., Hedman, E., Molmen, H. M., and Eik, L. The effects of a standardized herbal remedy ade from a subtype of Rosa canina in patients with osteoarthritis: a double-blind, randomized, placebo-controlled clinical trial. Curr Ther Res 2003;64(1):21-31.
- Winther, K. and Kharazmi, A. A powder prepared from seeds and shells of subtype of rose-hip Rosa canina reduces pain in patients with osteoarthritis of the hand - a double blind, placebo-controlled study. Osteoarthr Cartil 2004;12(Suppl 2):145.
- Winther, K., Apel, K., and Thamsborg, G. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol. 2005;34(4):302-308. View abstract.
- Ziegler, S. J. Planta Med 1986;52(5):383-387.
- Andersson U, Berger K, Hogberg A, et al. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr 2012;66:585-90. View abstract.
- Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Fresz T, Nagy E, Hilbert A, Tomcsanyi J. The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip tea. Int J Cardiol 2014;171(2):273-4. View abstract.
- García Hernández JÁ, Madera González D, Padilla Castillo M, Figueras Falcón T. Use of a specific anti-stretch mark cream for preventing or reducing the severity of striae gravidarum. Randomized, double-blind, controlled trial. Int J Cosmet Sci. 2013;35(3):233-7. View abstract.
- Han SH, Hur MH, Buckle J, et al. Effect of aromatherapy on symptoms of dysmenorrhea in college students: A randomized placebo-controlled clinical trial. J Altern Complement Med 2006;12(6):535-41. View abstract.
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. View abstract.
- Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503. View abstract.
- Oprica L, Bucsa C, Zamfiranche MM. Ascorbic acid content of rose hip fruit depending on altitude. Iran J Public Health 2015;44(1):138-9. View abstract.
- Van Steirteghem AC, Robertson EA, Young DS. Influence of large doses of ascorbic acid on laboratory test results. Clin Chem. 1978;24(1):54-7. View abstract.
- Willich SN, Rossnagel K, Roll S, et al. Rose hip herbal remedy in patients wth rheumatoid arthritis - a randomised controlled trial. Phytomedicine 2010;17:87-93. View abstract.
- Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
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