ASTRAGALUS

OTHER NAME(S):

Astragale, Astragale à Feuilles de Réglisse, Astragale Queue-de-Renard, Astragale Réglissier, Astragali, Astragalo, Astragalus Membranaceus, Astragalus mongholicus, Astragli Membranceus, Beg Kei, Bei Qi, Buck Qi, Chinese Astragalus, Huang Qi, Huang Se, Hwanggi, Membranous Milk Vetch, Milk Vetch, Mongolian Milk, Ogi, Phaca membranacea, Radix Astragali, Radix Astragalus, Réglisse Bâtarde, Réglisse Sauvage.<br/><br/>

Overview

Overview Information

Astragalus is an herb. The root is used to make medicine.

Astragalus is used for many conditions, but so far, there isn't enough scientific evidence to determine whether or not it is effective for any of them.

Astragalus is taken by mouth for seasonal allergies, heart failure, diabetes and to strengthen and regulate the immune system and many other conditions.

Some people use astragalus as a general tonic, to protect the liver, and to fight bacteria and viruses. It is also used to prevent and reduce side effects associated with cancer treatment.

Astragalus is commonly used in combination with other herbs.

Astragalus is sometimes applied to the skin to increase blood flow to the area and to speed wound healing.

Astragalus is injected in to the vein for the side effects of cancer treatment, heart failure, diabetes, lupus (systemic lupus erythematosus), and many other conidtions.

There are several different species of astragalus. Some species contain a toxin called swainsonine and have been linked to livestock poisonings. Some of these species include Astragalus lentiginosus, Astragalus mollissimus, and others. However, these species of astragalus are usually not found in dietary supplements used by humans. Most astragalus supplements contain Astragalus membranaceus.

How does it work?

Astragalus seems to stimulate and increase the immune system.

Uses

Uses & Effectiveness?

Possibly Effective for

Insufficient Evidence for

  • Seasonal allergies. Early research shows that taking a specific product containing 160 mg of astragalus root extract (Lectranal by Milsing d.o.o.) by mouth daily for 3-6 weeks improves symptoms such as running nose, itching, and sneezing in people with seasonal allergies.
  • Irregular menstruation (amenorrhea). Early research shows that taking a combination of astragalus and other herbal ingredients by mouth helps improve the regularity of menstrual cycles in women with irregular menstruation.
  • Chest pain (angina). Early research shows that taking 20 grams of astragalus by mouth three times daily for 2 weeks can improve some measures of heart function in people with chest pain.
  • Lack of new blood cells from bone marrow (aplastic anemia). Early research shows that giving astragalus intravenously (by IV) together with the steroid stanozolol improves symptoms and blood cell counts more than just the steroid alone in people with aplastic anemia.
  • Asthma. Early research shows that taking a combination of astragalus, cordyceps, Radix stemone (Bai Bu), bulbus fritillariae cirrhosae, and Baikal skullcap by mouth for 6 months does not improve asthma symptoms or lung function in children with mild asthma.
  • Reducing side effects of chemotherapy. Early research shows that giving astragalus intravenously (by IV) daily for 21 days during each course of chemotherapy reduces nausea, vomiting, diarrhea that is associated with chemotherapy treatments.
  • Chemotherapy-related fatigue. Clinical research suggests that administering 500 mg of a specific astragalus extract (PG2 by Pharmagenesis) intravenously (by IV) three times weekly for 4 weeks during chemotherapy improves fatigue scores after one week but not after two and four weeks.
  • A condition related to constant fatigue (Chronic fatigue syndrome): Early research shows that some herbal products containing astragalus and other herbal ingredients can reduce feelings of tiredness in people with chronic fatigue syndrome. However, not all doses seem to work. Also, it's not clear if the benefit is due to astragalus or other herbal ingredients.
  • Chronic fatigue syndrome. Early research shows that some herbal products containing astragalus and other herbal ingredients can reduce feelings of tiredness in people with chronic fatigue syndrome. However, not all doses seem to work. Also, it's not clear if the benefit is due to astragalus or other herbal ingredients.
  • Liver scarring (cirrhosis). Early research suggests that injecting a combination of astragalus and danshen in to the vein each day for up to 90 days might improve liver function in people with liver cirrhosis. It's too soon to know if the improvement is due to astragalus, danshen, or the combination.
  • Heart failure. Some early research shows that giving 60 grams of astragalus intravenously (by IV) for 20 days improves some symptoms of heart failure. However, other early research using the same dose shows no benefit. When taken by mouth along with conventional drugs for heart failure, some early research shows that astragalus can improve heart function and walking distance compared to conventional drugs alone.
  • Diabetes. Early research shows that giving astragalus intravenously (by IV) or taking astragalus by mouth for up to 4 months improves fasting and post-meal blood sugar levels in people with diabetes. Taking astragalus by mouth seems to improve these outcomes better than giving astragalus by IV. Taking astragalus by mouth might also improve the effect of insulin in the body. The effect of astragalus HbA1c, which gives an indication of average blood sugar over time, is unclear. Taking astragalus by mouth in combination with other herbal ingredients does not seem to improve blood sugar or insulin levels in people with diabetes.
  • Vision problems in people with diabetes (retinopathy). Early research suggests that taking herbal products containing astragalus for up to 10 months may improve vision in some people with vision damage caused by diabetes.
  • Hearing loss. Early research shows that giving astragalus intravenously (by IV) daily for 10 days can improve hearing in people with sudden deafness or hearing loss caused by very loud noise.
  • HIV/AIDS. Evidence on the effects of astragalus in people with HIV/AIDS is not clear. People treated with a specific combination containing Baikal skullcap root, glossy privet fruit, astragalus root, and Eupolyphaga et polyphage (Ailing granules) for 4 months show improvements in HIV/AIDs symptoms and immune function. However, taking a different combination containing licorice, yin chen, white mulberry, astragalus, and safflower by mouth for 12 weeks does not show the same benefits.
  • Kidney disease. Early research shows that taking astragalus along with conventional drugs for kidney disease can improve some measures of kidney function compared to conventional drugs alone. However, it's not known if astragalus can prevent death or increase the time until dialysis is needed. Patients with kidney disease are at a higher risk of infections. Early research shows that taking astragalus by mouth reduces infections in children with a certain kidney disease called nephrotic syndrome.
  • Lung cancer. Platinum-based chemotherapy is used to treat a type of lung cancer called non-small-cell lung cancer. Analysis of early research suggests that taking herbal products containing astragalus along with platinum-based chemotherapy can reduce the risk of death in people with advanced non-small-cell lung cancer after one, two, and three years of treatment compared to platinum-based chemotherapy alone.
  • Menopausal symptoms. Early research suggests that taking 3-6 grams of a specific combination of astragalus and dong quai called Dang Gui Buxue Tang might reduce hot flashes in menopausal women. However, lower doses do not seem to be effective.
  • Infection in the heart (myocarditis). Several early studies have used astragalus for the treatment of viral infections of the heart, but results are not clear. The best evidence suggests that taking astragalus preparations along with conventional drugs can reduce abnormal heartbeats related to the heart infection. However, taking astragalus seems to improve only some but not all blood markers of heart damage.
  • Fatigue after a stroke. Early research shows that taking astragalus for 4 weeks might improve fatigue in people who recently had a stroke.
  • Kidney failure. People who undergo heart surgery have an increase risk of sudden kidney failure after surgery. Giving astragalus intravenously (by IV) before, during, and after heart surgery seems to reduce kidney failure following heart surgery.
  • A chronic inflammatory disease called lupus . Early research shows that giving astragalus intravenously (by IV) for 12 days each month for 3 months with conventional drugs can improve symptoms and reduce infections in people with lupus.
  • A heart condition called tetralogy of Fallot. Giving astragalus intravenously (by IV) along with conventional treatment for 7 days after surgery to correct a heart condition called tetralogy of Fallot seems to improve heart function and reduce time until recovery compared to conventional treatment alone.
  • Weight loss. Early research suggests that taking a combination of astragalus with other ingredients with a low-calorie diet does not improve weight loss in overweight or obese women.
  • Cervical cancer.
  • Fibromyalgia.
  • Other conditions
More evidence is needed to rate astragalus for these uses.

Side Effects

Side Effects & Safety

Astragalus is POSSIBLY SAFE for most adults when taken by mouth or given intravenously (by IV) under the supervision of a medical professional. Doses of up to 60 grams/day for 4 months have been safely taken by mouth. Doses of 80 grams/day intravenously (by IV) have been safely administered for 4 months. When taken by mouth, astragalus may cause rash, itchy skin, nasal symptoms, or stomach discomfort. However, these events are uncommon. When given by IV, astragalus may cause dizziness or irregular heartbeat.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the safety of astragalus in humans during pregnancy and breast-feeding. However, some research in animals suggests that astragalus can be toxic to the mother and fetus. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other immune system conditions: Astragalus might make the immune system more active. This could worsen the symptoms of auto-immune diseases. Avoid using astragalus if you have any of these conditions.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Cyclophosphamide (Cytoxan, Neosar) interacts with ASTRAGALUS

    Cyclophosphamide (Cytoxan, Neosar) is used to decrease the immune system. Astragalus increases the immune system. Taking astragalus along with cyclophosphamide (Cytoxan, Neosar) might decrease the effectiveness of cyclophosphamide (Cytoxan, Neosar).

  • Lithium interacts with ASTRAGALUS

    Astragalus might have an effect like a water pill or "diuretic." Taking astragalus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

  • Medications that decrease the immune system (Immunosuppressants) interacts with ASTRAGALUS

    Astragalus increases the immune system. Taking astragalus along with medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system.<br/><br/>Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The appropriate dose of astragalus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for astragalus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Tian L, Ai J Wu X. Huangqi injection combined with dobutamine for the treatment of 54 patients with chronic pulmonary heart disease refractory heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2005;14(5):610.
  • Tianqing P, Yingzhen Y, Riesemann H, and et al. The inhibitory effect of Astragalus membranaceus on coxsackie B-3 virus RNA replication. Chinese Medical Sciences Journal 1995;10(3):146-150.
  • Wang H. Clinical research on Astragalus injection as assisted treatment for refractory heart failure. Journal of Emergency in Traditional Chinese Medicine 2005;14(11):1070-1071.
  • Wang L. The observation of Astragalus injection combined with Nitroglycerin for heart failure. Chongqing Medical Journal 2000;29(1):71-72.
  • Wang S, Yu L. Clinical observation of astragalus in treatment of heart failure in 102 cases with chronic pulmonary heart disease. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2002;9(4):230-231.
  • Wang, F. Twenty-eight cases of diabetic foot ulcer and gangrene treated with the Chinese herbal medicine combined with injection of ahylsantinfarctase. J.Tradit.Chin Med. 2002;22(1):3-4. View abstract.
  • Wang, F., Xiao, M. D., and Liao, B. [Effect of Astragalus on cytokines in patients undergoing heart valve replacement]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(6):495-498. View abstract.
  • Wang, G., Liu, C. T., Wang, Z. L., Yan, C. L., Luo, F. M., Wang, L., and Li, T. Q. Effects of Astragalus membranaceus in promoting T-helper cell type 1 polarization and interferon-gamma production by up-regulating T-bet expression in patients with asthma. Chin J Integr.Med 2006;12(4):262-267. View abstract.
  • Wang, H. Y. and Chen, Y. P. [Clinical observation on treatment of diabetic nephropathy with compound fructus arctii mixture]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(7):589-592. View abstract.
  • Wang, H., Chang, B., and Wang, B. [The effect of herbal medicine including astragalus membranaceus (fisch) bge, codonpsis pilosula and glycyrrhiza uralensis fisch on airway responsiveness]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 1998;21(5):287-288. View abstract.
  • Wang, J. J., Li, J., Shi, L., Lv, X. W., Cheng, W. M., and Chen, Y. Y. Preventive effects of a fractioned polysaccharide from a traditional Chinese herbal medical formula (Yu Ping Feng San) on carbon tetrachloride-induced hepatic fibrosis. J Pharm.Pharmacol. 2010;62(7):935-942. View abstract.
  • Wang, J., Zhang, Q. Y., and Chen, Y. X. [Effects of Astragalus membranaceus on cytokine secretion of peripheral dendritic cells in children with Henoch-Schonlein purpura in the acute phase]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(9):794-797. View abstract.
  • Wang, M. S., Li, J., Di, H. X., Li, Z. L., Yang, S. L., Hou, W., Yan, J. Y., and Zhao, X. M. Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia. Chin J Integr.Med 2007;13(2):98-102. View abstract.
  • Wang, R. T., Shan, B. E., and Li, Q. X. [Extracorporeal experimental study on immuno-modulatory activity of Astragalus memhranaceus extract]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(6):453-456. View abstract.
  • Wei Y, Li C Chen X Liu Y Luo N. Effect of Astragalus parenteral solution of cytokines and angiotensin II in patients with congestive heart failure. Chinese Journal of Clinical Rehabilitation 2006;10(3):54-56.
  • Wei, H., Sun, R., Xiao, W., Feng, J., Zhen, C., Xu, X., and Tian, Z. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol.Rep. 2003;10(5):1507-1512. View abstract.
  • Wei, J. A., Sun, L. M., and Chen, Y. X. [Effects of Ailing Granule on immuno-reconstruction in HIV/AIDS patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(4):319-321. View abstract.
  • Wei, L., Su, Z. J., and Guan, F. S. Randomized double-blind controlled study of therapeutic effects of Astragalus injection on children with cerebral palsy. Appl J Gen Pract 2008;3:234-235.
  • Wojcikowski, K., Wohlmuth, H., Johnson, D. W., and Gobe, G. Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy. Phytother.Res 2010;24(6):875-884. View abstract.
  • Wong, E. L., Sung, R. Y., Leung, T. F., Wong, Y. O., Li, A. M., Cheung, K. L., Wong, C. K., Fok, T. F., and Leung, P. C. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J Altern.Complement Med 2009;15(10):1091-1097. View abstract.
  • Wu C. Clinical effects of Huangqi injection on heart failure. Guilin Medicine 2001;3:19-20.
  • Wu L. Therapeutic effect observation of Huangqi injection for the treatment of chronic pulmonary heart failure. Xinjiang Medical Journal 2004;34:107-108.
  • Wu, H. M., Tang, J. L., Cao, L., Sha, Z. H., and Li, Y. Interventions for preventing infection in nephrotic syndrome. Cochrane Database Syst.Rev. 2012;4:CD003964. View abstract.
  • Wu, J. H., Li, Q., Wu, M. Y., Guo, D. J., Chen, H. L., Chen, S. L., Seto, S. W., Au, A. L., Poon, C. C., Leung, G. P., Lee, S. M., Kwan, Y. W., and Chan, S. W. Formononetin, an isoflavone, relaxes rat isolated aorta through endothelium-dependent and endothelium-independent pathways. J Nutr Biochem. 2010;21(7):613-620. View abstract.
  • Wu, Y., Ou-Yang, J. P., Wu, K., Wang, Y., Zhou, Y. F., and Wen, C. Y. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol.Sin. 2005;26(3):345-352. View abstract.
  • Xi Z, Jin X. Therapeutic effect observation of Astragalus injection for congestive heart failure. Modern Medicine & Health 2005;21(17):2337-2338.
  • Xia, D., Zeng, Y., and Liao, Z. [Clinical and experimental study of yushen jiangtang tablet in treating non-insulin dependent diabetes mellitus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(2):90-92. View abstract.
  • Xiao, H. B., Krucker, M., Albert, K., and Liang, X. M. Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. J Chromatogr.A 4-2-2004;1032(1-2):117-124. View abstract.
  • Xiong, M., He, Q., Lai, H., Huang, W., Wang, L., and Yang, C. Radix astragali injection enhances recovery from sudden deafness. Am J Otolaryngol. 2012;33(5):523-527. View abstract.
  • Xiong, M., He, Q., Lai, H., Huang, W., Wang, L., Yang, C., and Wang, J. Radix Astragali injection enhances recovery from acute acoustic trauma. Acta Otolaryngol. 2011;131(10):1069-1073. View abstract.
  • Xu, G. H., Yuan, L., Li, Y., Xie, P., Zhao, J. Y., and Chen, Y. H. [Clinical observation of Astragalus Injection in treatment of renal injury in patients with primary hypertension]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(5):530-532. View abstract.
  • Yang H, Kang X. Effects of Astragalus membranaceus on plasma BNP and NT-BNP during chronic heart failure. Chinese Health Care 2005;13(18):9-10.
  • Yang J, Xie Q. Therapeutic effect observation of Huangqi injection for chronic heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2000;9(12):1331.
  • Yang L, Zhang Y Yang G et al. The therapeutic effect of Astragalus injection on chronic heart failure. Shanghai Medical & Pharmaceutical Journal 1996;2:17-18.
  • Yang Y, Jin P, Guo Q, and et al. Effect of Astragulas membranaceus on natural killer cell activity and induction of alpha- and gamma- interferon in patients with coxsackie B viral myocarditis. Chinese Medical Journal 1990;103(4):304-307.
  • Yang Y. Therapeutic effect observation of Astragalus injection combined with Western medicine for congestive heart failure. World Health Digest 2007;4(11):31-32.
  • Yang Z, Liu M. Effect of Huangqi injection on incidence of digitalism during the treatment of congestive heart failure. Traditional Chinese Drug Research & Clinical Pharmacology 1998;9(2):80-81.
  • Yang, Q. Y., Lu, S., and Sun, H. R. [Effects of astragalus on cardiac function and serum tumor neorosis factor-alpha level in patients with chronic heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2010;30(7):699-701. View abstract.
  • Yang, Q. Y., Lu, S., and Sun, H. R. Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure. Chin J Integr Med 2011;17(2):146-149. View abstract.
  • Yang, S. P., Dong, H., and Wu, Y. C. [Clinical effect of milkvetch extract oral liquid in preventing and treating children's recurrent respiratory tract infection]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(6):544-547. View abstract.
  • Yao, X. J., Wainberg, M. A., and Parniak, M. A. Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. Virology 1992;187(1):56-62. View abstract.
  • Ye, M. N. and Chen, H. F. [Effects of Astragalus injection on proliferation of basal-like breast cancer cell line MDA-MB-468]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(4):399-404. View abstract.
  • Ye, Z. B., Wang, F. J., Zhang, G. Q., Yang, W. M., Qin, H. S., and Liu, X. T. [Effects of Astragalus Membranaceus Injection on TNF-alpha-induced release of inflammatory factors from HUVECs and the molecular mechanisms]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(6):1137-1140. View abstract.
  • Yin J, Wei Q. Therapeutic effect of Astragalus membranaceus injection on heart failure caused by pulmonary heart disease. Hebei Journal TCM 2002;24(4):308-309.
  • Yin X, Zhang S, Kong Y, and et al. Observation on efficiency of jiangtang capsule in treating diabetes mellitus type 2 with hyperlipidemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):214-216.
  • Yong WU, Yand OU, Ping J, Ke WU, and et al. Hypoglycemic effect of astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol.Sin. 2005;26(2):345-352.
  • Yuan, Y., Sun, M., and Li, K. S. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8. World J Gastroenterol. 8-7-2009;15(29):3676-3680. View abstract.
  • Zeng J. The clinical observation of Astragalus injection for congestive heart failure. Academic Proceedings of National Emergency Medicine Conference on Serious Disease 2005;156-157.
  • Zhai L, Wang M Yue J Ma Y. Clinical observation of Huangqi Injection for congestive heart failure. Shanghai Medical & Pharmaceutical Journal 1995;11:11-12.
  • Zhang D. Therapeutic effect observation of Astragalus injection for the treatment of 42 cases of pulmonary heart failure. Modern Journal of Integrated Traditional Chinese and Western Medicine 2002;11(5):408.
  • Zhang HE and et al. Treatment of adult diabetes with Jiangtangjia tablet. Journal of Traditional Chinese Medicine 1986;27(4):37-39.
  • Zhang J, Jia L Du Y. Effects of Astragalus on cardiac function and hemorrheology in aged patients with congestive heart failure. Practical Geriatrics 2003;17(4):192-194.
  • Zhang L, Wang G Zhang G. Therapeutic effect observation of Huangqi injection as assisted treatment for pulmonary heart failure. Tibetan Medical Journal 2000;21(2):14-15.
  • Zhang, J. G., Gao, D. S., and Wei, G. H. [Clinical study on effect of Astragalus injection on left ventricular remodeling and left ventricular function in patients with acute myocardial infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(5):346-348. View abstract.
  • Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):187-190. View abstract.
  • Zhang, L. F., Cheng, W. D., Gui, M. M., Li, X. Y., and Wei, D. F. [Comparative study of Radix Hedyseri as sulstitute for Radix Astragali of yupingfeng oral liquid on cellular immunity in immunosuppressed mice]. Zhong.Yao Cai. 2012;35(2):269-273. View abstract.
  • Zhang, W. J., Hufnagl, P., Binder, B. R., and Wojta, J. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thromb.Haemost. 2003;90(5):904-914. View abstract.
  • Zhang, Y., Liu, J., Wang, J., and He, Q. Traditional Chinese Medicine for treatment of cerebral palsy in children: a systematic review of randomized clinical trials. J Altern.Complement Med 2010;16(4):375-395. View abstract.
  • Zhang, Z. X., Wu, L. L., and Chen, M. [Effect of lixu jieyu recipe in treating 75 patients with chronic fatigue syndrome]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(6):501-505. View abstract.
  • Zhao Z, Liu F Yang L. Huangqi injection as the assisted treatment for congestive heart failure. The Practical Journal of Integrating Chinese with Modern Medicine 1998;11(1):26.
  • Zhao, K. S., Mancini, C., and Doria, G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology 1990;20(3):225-233. View abstract.
  • Zhao, K. W. and Kong, H. Y. [Effect of Astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells]. Zhongguo Zhong Xi.Yi.Jie.He.Za Zhi. 1993;13(5):263-5, 259. View abstract.
  • Zhao, X. Z. [Effects of Astragalus membranaceus and Tripterygium hypoglancum on natural killer cell activity of peripheral blood mononuclear in systemic lupus erythematosus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1992;12(11):669-71, 645. View abstract.
  • Zheng, R. 120 cases of viral myocarditis treated with integrated Chinese and western medicine [in Chinese]. The Journal of Medical Theory and Practice 2003;16(8):907-908.
  • Zhou Y, Yu, X. H., and Yang, Y. H. Observation of astragaloside on treating viral myocarditis in 40 cases [in Chinese]. Chinese Journal of the Practical with Modern Medicine 2006;19(8):880-881.
  • Zhou Z, Cai A Luo C Zeng X. Clinical observation of Astragalus injection as adjuvant therapy for coronary heart failure. Hubei Journal of Traditional Chinese Medicine 2002;24(9):11-12.
  • Zhou, R. F., Liu, P. X., and Tan, M. [Effect of Astragalus mongholicus injection on proliferation and apoptosis of hormone sensitive (MCF-7) breast cancer cell lines with physiological dose E2]. Zhong.Yao Cai. 2009;32(5):744-747. View abstract.
  • Zhou, S., Shao, W., and Zhang, W. [Clinical study of Astragalus injection plus ligustrazine in protecting myocardial ischemia reperfusion injury]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2000;20(7):504-507. View abstract.
  • Zhou, Y, Huang, Z, Huang, T, and et al. Clinical study of Shengxue Mixture in treating aplastic anemia. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189.
  • Zou, F., Mao, X. Q., Wang, N., Liu, J., and Ou-Yang, J. P. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK. Acta Pharmacol.Sin. 2009;30(12):1607-1615. View abstract.
  • Zou, Y. H. and Liu, X. M. [Effect of astragalus injection combined with chemotherapy on quality of life in patients with advanced non-small cell lung cancer]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):733-735. View abstract.
  • Zuo, C., Xie, X. S., Qiu, H. Y., Deng, Y., Zhu, D., and Fan, J. M. Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-beta in rats with unilateral ureteral obstruction. J Zhejiang.Univ Sci B 2009;10(5):380-390. View abstract.
  • Carod-Artal FJ. [Neurological syndromes linked with the intake of plants and fungi containing a toxic component (I). Neurotoxic syndromes caused by the ingestion of plants, seeds and fruits]. Rev Neurol 2003;36:860-71. View abstract.
  • Cheng L, Zhang G, Zhou Y, Lu X, Zhang F, Ye H, Duan J. Systematic review and meta-analysis of 16 randomized clinical trials of radix astragali and its prescriptions for diabetic retinopathy. Evid Based Complement Alternat Med. 2013;2013:762783. View abstract.
  • Chu DT, Lepe-Zuniga J, Wong WL, et al. Fractionated extract of Astragalus membranaceus, a Chinese medicinal herb, potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2. J Clin Lab Immunol 1988;26:183-7. View abstract.
  • Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9. View abstract.
  • Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. I. Immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated Astragalus membranaceus in vitro. J Clin Lab Immunol 1988;25:119-23. View abstract.
  • He H, Zhou X, Wang Q, Zhao Y. Does the couse of astragalus-containing Chinese herbal prescriptions and radiotherapy benefit to non-small-cell lung cancer treatment: a meta-analysis of randomized trials. Evid Based Complement Alternat Med. 2013;2013:426207. View abstract.
  • Hong CY, Ku J, Wu P. Astragalus membranaceus stimulates human sperm motility in vitro. Am J Chin Med 1992;20:289-94. View abstract.
  • Hong CY, Lo YC, Tan FC, et al. Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med 1994;22:63-70. View abstract.
  • Hou YD, Ma GL, Wu SH, et al. Effect of Radix Astragali seu Hedysari on the interferon system. Chin Med J (Engl) 1981;94:35-40. View abstract.
  • Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90. View abstract.
  • Li X, Qu L, Dong Y, Han L, Liu E, Fang S, Zhang Y, Wang T. A review of recent research progress on the astragalus genus. Molecules. 2014 Nov 17;19(11):18850-80. View abstract.
  • Liu CH, Tsai CH, Li TC, et al. Effects of the traditional Chinese herb Astragalus membranaceus in patients with poststroke fatigue: A double-blind, randomized, controlled preliminary study. J Ethnopharmacol. 2016;194:954-962. doi: 10.1016/j.jep.2016.10.058. View abstract.
  • Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23. View abstract.
  • Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81. View abstract.
  • McCulloch M, See C, Shu XJ, et al. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol 2006;24:419-30. View abstract.
  • Piao YL, Liang XC. Astragalus membranaceus injection combined with conventional treatment for viral myocarditis: a systematic review of randomized controlled trials. Chin J Integr Med. 2014 Oct;20(10):787-91. View abstract.
  • Prieto JM, Recio MC, Giner RM, et al. Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. J Pharm Pharmacol 2003;55:1275-82. View abstract.
  • Qun L, Luo Q, Zhang ZY, et al. Effects of astragalus on IL-2/IL-2R system in patients with maintained hemodialysis. Clin Nephrol 1999;52:333-4. View abstract.
  • Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8. View abstract.
  • Shao BM, Xu W, Dai H, et al. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun 2004;320:1103-11. View abstract.
  • Stegelmeier BL, James LF, Panter KE, et al. The pathogenesis and toxicokinetics of locoweed (Astragalus and Oxytropis spp.) poisoning in livestock. J Nat Toxins 1999;8:35-45. View abstract.
  • Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37.. View abstract.
  • Sun Y, Hersh EM, Talpaz M, et al. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer 1983;52:70-3. View abstract.
  • Tan, Y. B. Clinical observation on the effect of Astragalactoside injection in the treatment of infantile viral myocarditis [in Chinese]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2003;10(1):60-1.
  • Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. View abstract.
  • Tong X, Xiao D, Yao F, Huang T. Astragalus membranaceus as a cause of increased CA19-9 and liver and kidney cysts: a case report. J Clin Pharm Ther. 2014 Oct;39(5):561-3. View abstract.
  • Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
  • Wang CC, Cheng KF, Lo WM, Law C, Li L, Leung PC, Chung TK, Haines CJ. A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) for moderate to severe menopausal symptoms and quality of life in postmenopausal women. Menopause. 2013 Feb;20(2):223-31. View abstract.
  • Wu, J. W., Tao, N., Jiang, R. F., and Feng, H. D. Clinical observation on infantile viral myocarditis treated with radix astragali granules [in Chinese]. Journal of Pediatric Pharmacy 2009;15(1):23-5.
  • Xu F, Zhang Y, Xiao S, et al. Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo. Drug Metab Dispos 2006;34:913-24. View abstract.
  • Yang YZ, Jin PY, Guo Q, et al. Treatment of experimental Coxsackie B-3 viral myocarditis with Astragalus membranaceus in mice. Chin Med J (Engl) 1990;103:14-8. View abstract.
  • Yang, Y. X. Clinical research on treatment of acute viral myocarditis by Astragalactoside injection [in Chinese]. World Health Digest Medical Periodical 2008;5(9):35.
  • Yu SY, Ouyang HT, Yang JY, et al. Subchronic toxicity studies of Radix Astragali extract in rats and dogs. J Ethnopharmacol. 2007 Mar 21;110(2):352-5. View abstract.
  • Zhang H, Huang J. Preliminary study of traditional Chinese medicine treatment of minimal brain dysfunction: analysis of 100 cases. Chung Hsi I Chieh Ho Tsa Chih 1990;10:278-9, 260. View abstract.
  • Zhang HW, Lin ZX, Xu C, Leung C, Chan LS. Astragalus (a traditional Chinese medicine) for treating chronic kidney disease. Cochrane Database Syst Rev. 2014 Oct 22;10:CD008369. View abstract.
  • Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y. Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:842824. View abstract.
  • Ahmed, M. S., Hou, S. H., Battaglia, M. C., Picken, M. M., and Leehey, D. J. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis 2007;50(6):1028-1032. View abstract.
  • Ai, P., Yong, G., Dingkun, G., Qiuyu, Z., Kaiyuan, Z., and Shanyan, L. Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. J Ethnopharmacol. 3-28-2008;116(3):413-421. View abstract.
  • Aldarmaa, J., Liu, Z., Long, J., Mo, X., Ma, J., and Liu, J. Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem.Res 2010;35(1):33-41. View abstract.
  • Auyeung, K. K., Law, P. C., and Ko, J. K. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Int.J Mol.Med 2009;23(2):189-196. View abstract.
  • Bai R, Li Q Fang X. Therapeutic effect observation of Astragalus injection for the treatment of 25 cases of pulmonary heart failure. Journal of Shanxi Medical College of Continuing Education 1999;9(1):39-40.
  • Bao X. Astragalus injection for aged people with congestive heart failure. Pharmacology and Clinics of Chinese Materia Medica 1999;15(6):39-40.
  • Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res 2006;20(8):687-695. View abstract.
  • Bu Q, Li S. The curative effect of Astragalus injection for aged patients with congestive heart failure. Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease 2005;3(11):1006.
  • Cai Q, Ma H Zhou J. Analysis the improvement of cardiac function of Astragalus injection for chronic congestive heart failure. Shanxi Medical Journal 2005;34(7):860-861.
  • Cai, X. Y., Xu, Y. L., and Lin, X. J. [Effects of radix Astragali injection on apoptosis of lymphocytes and immune function in patients with systemic lupus erythematosus]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(5):443-445. View abstract.
  • Cassileth, B. R., Rizvi, N., Deng, G., Yeung, K. S., Vickers, A., Guillen, S., Woo, D., Coleton, M., and Kris, M. G. Safety and pharmacokinetic trial of docetaxel plus an Astragalus-based herbal formula for non-small cell lung cancer patients. Cancer Chemother.Pharmacol. 2009;65(1):67-71. View abstract.
  • Cha, R. J., Zeng, D. W., and Chang, Q. S. [Non-surgical treatment of small cell lung cancer with chemo-radio- immunotherapy and traditional Chinese medicine]. Zhonghua Nei Ke.Za Zhi 1994;33(7):462-466. View abstract.
  • Chao, M., Zou, D., Zhang, Y., Chen, Y., Wang, M., Wu, H., Ning, G., and Wang, W. Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine. 2009;36(2):268-274. View abstract.
  • Chen, C. J., Li, Z. L., Fu, Q., Liu, Y., Lei, X., Wu, H. C., and Liu, Y. F. [Effect of Astragalus polysaccharides on the phenotype and functions of human dendritic cells in vitro]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(6):1192-1194. View abstract.
  • Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest Med 2012;35(1):E1-11. View abstract.
  • Chen, K. T., Su, C. H., Hsin, L. H., Su, Y. C., Su, Y. P., and Lin, J. G. Reducing fatigue of athletes following oral administration of huangqi jianzhong tang. Acta Pharmacol.Sin. 2002;23(8):757-761. View abstract.
  • Chen, L. P., Zhou, Q. L., and Yang, J. H. [Protective effects of astragali injection on tubular in patients with primary nephrotic syndrome]. Zhong.Nan.Da.Xue.Xue.Bao.Yi.Xue.Ban. 2004;29(2):152-153. View abstract.
  • Chen, L. X., Liao, J. Z., and Guo, W. Q. [Effects of Astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(3):141-143. View abstract.
  • Chen, L., Xie, C., and Wu, L. Point injection of injectio radici astragali for treatment of post-chemotherapy adverse reactions. J Tradit.Chin Med 2005;25(1):21-22. View abstract.
  • Chen, M. L., Liu, W. J., Wang, C. Y., Zhu, X. M., Yin, J. F., Wang, D. X., and Liu, P. [Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats]. Zhongguo Zhong.Yao Za Zhi. 2003;28(8):746-751. View abstract.
  • Chen, W., Li, Y. M., and Yu, M. H. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. J Diabetes Complications 2010;24(3):199-208. View abstract.
  • Cho, J. H., Cho, C. K., Shin, J. W., Son, J. Y., Kang, W., and Son, C. G. Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: a randomised, double-blind, controlled pilot study. Complement Ther.Med 2009;17(3):141-146. View abstract.
  • Cho, W. C. and Leung, K. N. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J Ethnopharmacol. 8-15-2007;113(1):132-141. View abstract.
  • Chu G, Peng X. Astragalus injection as assisted treatment for refractory heart failure. Hubei Journal of Traditional Chinese Medicine 2000;22(10):29.
  • Dong, D. C., Zhou, L. F., and Chen, J. X. [Changes in proteinuria, renal function and immunity after treatment with injections of a solution of Astragalus membranaceus]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1987;7(7):403-4, 388. View abstract.
  • Dong, J., Gu, H. L., Ma, C. T., Zhang, F., Chen, Z., and Zhang, Y. [Effects of large dose of Astragalus membranaceus on the dendritic cell induction of peripheral mononuclear cell and antigen presenting ability of dendritic cells in children with acute leukemia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(10):872-875. View abstract.
  • Duan, P. and Wang, Z. M. [Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients of malignant tumor]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(7):515-517. View abstract.
  • Fan L. Observation of Chinese and Western medicine for the treatment of 72 cases with congestive heart failure. Journal of Practical Traditional Chinese Medicine 2004;20(9):501.
  • Fang Z, Qin Y. Clinical observation of Huangqi injection for congestive heart failure. Central Plains Medical Journal 2003;30(14):6-7.
  • Firenzuoli, F., Gori, L., Di Simone, L., and Morsuillo, M. Important bias in the Astragalus meta-analysis. J Clin Oncol 7-1-2006;24(19):3215-3216. View abstract.
  • Fu X. Clinical experience in Astragalus injection for congestive heart failure. Journal of Chinese Practical Medicine 2000;2(9):72.
  • Fu, S., Zhang, J., Menniti-Ippolito, F., Gao, X., Galeotti, F., Massari, M., Hu, L., Zhang, B., Ferrelli, R., Fauci, A., Firenzuoli, F., Shang, H., Guerra, R., and Raschetti, R. Huangqi injection (a traditional Chinese patent medicine) for chronic heart failure: a systematic review. PLoS.One. 2011;6(5):e19604. View abstract.
  • Gao J. Clinical observation of Huangqi Injection for congestive heart failure. Journal of Guangdong College of Pharmacy 2005;21(5):610-611.
  • Gao Z, Zhang L Xu Y Liu L Zhang L. Clinical observation of Astragalus injection for congestive heart failure. Hebei Medicine 1999;5(5):7-9.
  • Gao, S. R., Bu, J. H., and Zhu, L. Z. [Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(7):593-595. View abstract.
  • Gao, X. H., Xu, X. X., Pan, R., Li, Y., Luo, Y. B., Xia, Y. F., Murata, K., Matsuda, H., and Dai, Y. Saponin fraction from Astragalus membranaceus roots protects mice against polymicrobial sepsis induced by cecal ligation and puncture by inhibiting inflammation and upregulating protein C pathway. J Nat.Med 2009;63(4):421-429. View abstract.
  • Gu X, Shang S Guo R. Astragalus injection as adjuvant therapy for 68 cases with congestive heart failure. Herald of Medicine 2003;22(8):556-557.
  • Gu, W., Yang, Y. Z., and He, M. X. [A study on combination therapy of Western and traditional Chinese medicine of acute viral myocarditis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(12):713-716. View abstract.
  • Guo H, Chen H. Astragalus injection for 42 cases with chronic congestive heart failure. Central Plain Medical Journal 2006;33(2):85-86.
  • Guo H, Liu L Yuan W Miao Z. Therapeutic effect observation of Huangqi injection for the treatment of chronic pulmonary heart disease with heart failure. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine 2005;5(4):22.
  • Guo, Q., Peng, T. Q., and Yang, Y. Z. [Effect of Astragalus membranaceus on Ca2+ influx and coxsackie virus B3 RNA replication in cultured neonatal rat heart cells]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(8):483-485. View abstract.
  • Haines, C. J., Lam, P. M., Chung, T. K., Cheng, K. F., and Leung, P. C. A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women. Climacteric. 2008;11(3):244-251. View abstract.
  • He, Z. P., Wang, D. Z., Shi, L. Y., and Wang, Z. Q. Treating amenorrhea in vital energy-deficient patients with angelica sinensis-astragalus membranaceus menstruation-regulating decoction. J Tradit.Chin Med 1986;6(3):187-190. View abstract.
  • Hoo, R. L., Wong, J. Y., Qiao, C., Xu, A., Xu, H., and Lam, K. S. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutr Metab (Lond) 2010;7:67. View abstract.
  • Hu J, Gan J. Astragalus injection for 30 cases with chronic heart failure. Chin J Clin Pharmacol Ther 2001;6(1):78.
  • Hu S. Therapeutic effect observation of Huangqi injection as assisted treatment for chronic heart failure. Medicine Innovation Research 2008;5(2):102-103.
  • Huang, C. L. and Lu, Y. P. [Effect of Astragalus injection on insulin resistance in auxiliary treating patients with diabetes mellitus type 2]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):779-780. View abstract.
  • Huh, J. E., Kwon, N. H., Baek, Y. H., Lee, J. D., Choi, D. Y., Jingushi, S., Kim, K. I., and Park, D. S. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Int Immunopharmacol. 2009;9(12):1357-1365. View abstract.
  • Huh, J. E., Seo, D. M., Baek, Y. H., Choi, D. Y., Park, D. S., and Lee, J. D. Biphasic positive effect of formononetin on metabolic activity of human normal and osteoarthritic subchondral osteoblasts. Int Immunopharmacol. 2010;10(4):500-507. View abstract.
  • Jiangbo, Z., Xuying, W., Yuping, Z., Xili, M., Yiwen, Z., and Tianbao, Z. Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits. J Appl.Toxicol. 2009;29(5):381-385. View abstract.
  • Jiao X, Duan Y. Clinical research of Huangqi Injection on left ventricular remodeling in congestive heart failure. Journal of Shanxi College of Traditional Chinese Medicine 2006;29(3):19-20.
  • Jin, R., Wan, L. L., Mitsuishi, T., Kodama, K., and Kurashige, S. [Immunomodulative effects of Chinese herbs in mice treated with anti- tumor agent cyclophosphamide]. Yakugaku Zasshi 1994;114(7):533-538. View abstract.
  • Kajimura, K., Takagi, Y., Ueba, N., Yamasaki, K., Sakagami, Y., Yokoyama, H., and Yoneda, K. Protective effect of astragali radix by oral administration against Japanese encephalitis virus infection in mice. Biol.Pharm.Bull. 1996;19(9):1166-1169. View abstract.
  • Kim, C., Ha, H., Lee, J. H., Kim, J. S., Song, K., and Park, S. W. Herbal extract prevents bone loss in ovariectomized rats. Arch.Pharm.Res. 2003;26(11):917-924. View abstract.
  • Ko, J. K. and Chik, C. W. The protective action of radix Astragalus membranaceus against hapten-induced colitis through modulation of cytokines. Cytokine 2009;47(2):85-90. View abstract.
  • Ko, J. K., Lam, F. Y., and Cheung, A. P. Amelioration of experimental colitis by Astragalus membranaceus through anti-oxidation and inhibition of adhesion molecule synthesis. World J Gastroenterol 10-7-2005;11(37):5787-5794. View abstract.
  • Kobayashi, H., Mizuno, N., Teramae, H., Kutsuna, H., Ueoku, S., Onoyama, J., Yamanaka, K., Fujita, N., and Ishii, M. Diet and Japanese herbal medicine for recalcitrant atopic dermatitis: efficacy and safety. Drugs Exp Clin Res. 2004;30(5-6):197-202. View abstract.
  • Kusum, M., Klinbuayaem, V., Bunjob, M., and Sangkitporn, S. Preliminary efficacy and safety of oral suspension SH, combination of five chinese medicinal herbs, in people living with HIV/AIDS ; the phase I/II study. J.Med.Assoc.Thai. 2004;87(9):1065-1070. View abstract.
  • Lau, T. W., Chan, Y. W., Lau, C. P., Lau, K. M., Lau, C. B., Fung, K. P., Leung, P. C., and Ho, Y. Y. Radix Astragali and Radix Rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues. Phytother.Res 2009;23(6):809-815. View abstract.
  • Lee, J. J. and Lee, J. J. A phase II study of an herbal decoction that includes Astragali radix for cancer-associated anorexia in patients with advanced cancer. Integr.Cancer Ther. 2010;9(1):24-31. View abstract.
  • Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11(2):142-148. View abstract.
  • Lee, T. M., Guo, L. G., Shi, H. Z., Li, Y. Z., Luo, Y. J., Sung, C. Y., Chan, C. C., and Lee, T. M. Neural correlates of traditional Chinese medicine induced advantageous risk-taking decision making. Brain Cogn 2009;71(3):354-361. View abstract.
  • Lei, Z. Y., Qin, H., and Liao, J. Z. [Action of Astragalus membranaceus on left ventricular function of angina pectoris]. Zhongguo Zhong Xi Yi Jie He Za Zhi 1994;14(4):199-202. View abstract.
  • Li C, Zhu X. Therapeutic effect observation of Astragalus injection as assisted treatment for chronic congestive heart failure. J Med Theor & Prac 2002;15(11):1277-1278.
  • Li H, Xu J. The curative effect of the treatment of chronic congestive cardiac deficiency by Astragalue injection and digoxin. Sichuan Journal of Physiological Sciences 2006;28(2):81.
  • Li J, Xu B Xue J Chen L Ling W. Clinical observation on the effect of sodium nitroprusside combined with milkvetch root injection on chronic congestive heart failure. China Tropical Medicine 2007;7(8):1343-1344.
  • Li S, Hao J Wu F et al. Clinical therapeutic effect observation of different doses of Huangqi injection for congestive heart failure. Chinese Journal of the Practical Chinese with Modem Medicine 2003;3(16):1665-1667.
  • Li S, Lv M. Astragalus injection as the assisted treatment for 30 cases with pulmonary heart failure. Journal of Anhui TCM College 1997;16(2):19-20.
  • Li W, Zhao W. Clinical observation of Astragalus injection for 50 cases with chronic congestive heart failure. The Seventh National Chinese and Western Medicine Academic and Working Communication Conference of Rural Foot Layer 2002;35-37.
  • Li, D. P., Chen, Q., and Yi, L. [Effects of yiqi huoxue method on cardiac function in patients with congestive heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(6):552-554. View abstract.
  • Li, H. B., Ge, Y. K., Zhang, L., and Zheng, X. X. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life Sci 8-15-2006;79(12):1186-1193. View abstract.
  • Li, M., Wang, W., Xue, J., Gu, Y., and Lin, S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol. 1-27-2011;133(2):412-419. View abstract.
  • Li, N. Q. [Clinical and experimental study on shen-qo injection with chemotherapy in the treatment of malignant tumor of digestive tract]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1992;12(10):579, 588-592. View abstract.
  • Li, S. M., Yan, J. X., and Yang, L. [Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;26(6):504-507. View abstract.
  • Li, Z. P., Cao, Q., and Xing, Q. S. [Effect of Milkvetch Injection on cardiac function and hemodynamics in children with tetralogy of Fallot after radical operation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(12):891-894. View abstract.
  • Liang, H. Y., Hou, F., Ding, Y. L., Zhang, W. N., Huang, X. H., Zhang, B. Y., and Liu, Y. [Clinical evaluation of the antioxidant activity of astragalus in women with gestational diabetes]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29(7):1402-1404. View abstract.
  • Liu A. Clinical observation of Huangqi injection for chronic congestive heart failure. Zhejiang JLTCWM 2005;15(1):32.
  • Liu C, Li Y. Clinical observation of Huangqi injection for congestive heart failure. Journal of Liaoning College of TCM 2004;6(5):390.
  • Liu Y, Li Y. Clinical research on Huangqi injection for congestive heart failure. Journal of Practical Traditional Chinese Medicine 2005;21(4):198-199.
  • Liu Y, Wang H. Curative effect observation of traditional Chinese and western medicine for the treatment of congestive heart failure. Tianjin Journal of Traditional Chinese Medicine 2001;18(5):8.
  • Liu Y. Effect of astragalus injection on heart failure in senile patients. Journal of Xinxiang Medical College 2005;22(3):244-245.
  • Liu Z. Effect of Huangqi injection on cardiac output of chronic heart failure. Journal of Chinese Modern Medicine 2006;3:5.
  • Liu, J. P., Yang, M., and Du, X. M. Herbal medicines for viral myocarditis. Cochrane.Database.Syst.Rev. 2004;(3):CD003711. View abstract.
  • Liu, J., Liang, P., Yin, C., Wang, T., Li, H., Li, Y., and Ye, Z. Effects of several Chinese herbal aqueous extracts on human sperm motility in vitro. Andrologia 2004;36(2):78-83. View abstract.
  • Liu, Q. Y., Yao, Y. M., Zhang, S. W., and Sheng, Z. Y. Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low) DCs in vitro. J Ethnopharmacol. 7-8-2010; View abstract.
  • Liu, W. J., Liu, B., Guo, Q. L., Zhang, Y. C., Yuan, Y. J., Fu, X. D., Deng, Z. H., and Lin, J. [Influence of ganciclovir and astragalus membranaceus on proliferation of hematopoietic progenitor cells of cord blood after cytomegalovirus infection in vitro]. Zhonghua Er.Ke.Za Zhi. 2004;42(7):490-494. View abstract.
  • Liu, X., Yang, Y., Zhang, X., Xu, S., He, S., Huang, W., and Roberts, M. S. Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2 cell. J Gastroenterol.Hepatol. 2010;25(2):420-426. View abstract.
  • Liu, Z. G., Xiong, Z. M., and Yu, X. Y. [Effect of astragalus injection on immune function in patients with congestive heart failure]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(5):351-353. View abstract.
  • Liu, Z. L., Liu, Z. J., Liu, J. P., and Kwong, J. S. Herbal medicines for viral myocarditis. Cochrane Database Syst.Rev. 2012;11:CD003711. View abstract.
  • Liu, Z. Q., Li, Q. Z., and Qin, G. J. [Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(4):274-276. View abstract.
  • Lu Q. The treatment of 80 cases of intractable heart failure with traditional Chinese and Western medicine. Modern Journal of Integrated Traditional Chinese and Western Medicine 2000;9(1):61.
  • Lu Z, Zhao D Liu Y. Clinical observation of Astragalus injection for coronary heart failure. Public Medical Forum Magazine 2006;10(1):1-2.
  • Lu, Z. M., Qian, X. H., Chen, Z. W., Zhang, C. H., Guo, L. S., and Chen, J. [Prospective clinical study of radix astragali and its compound prescription for treatment of beta-thalassemia in children]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2012;14(5):344-349. View abstract.
  • Luo Q, Wang Y Hu M. Therapeutic effect observation of Astragalus injection with conventional therapy for 46 elderly patients with chronic congestive heart failure. Heilongjiang Journal of Traditional Chinese Medicine 2004;3:8-9.
  • Luo X. Clinical observation of Astragalus injection for 30 cases with congestive heart failure. Journal of Emergency in Traditional Chinese Medicine 2003;12(1):35.
  • Lv J. Observation of western medicine combined with Huangqi injection for 36 patients with chronic heart failure. Journal of Practical Traditional Chinese Medicine 2008;24(3):164-165.
  • Ma L, Yu J Han Y. Clinical observation of Huangqi injection for the treatment of pulmonary heart disease refractory heart failure. Henan Traditional Chinese Medicine 2005;25(10):78.
  • Ma Z, Cheng X Wang L. Huangqi injection as the assisted treatment for 86 cases with chronic pulmonary heart failure. Shanxi Journal of Traditional Chinese Medicine 2001;22(10):579-580.
  • McCulloch, M., Broffman, M., Gao, J., and Colford, J. M., Jr. Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: a meta-analysis of randomized, controlled trials. Am J Public Health 2002;92(10):1619-1628. View abstract.
  • Motomura, K., Fujiwara, Y., Kiyota, N., Tsurushima, K., Takeya, M., Nohara, T., Nagai, R., and Ikeda, T. Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. J Agric.Food Chem. 9-9-2009;57(17):7666-7672. View abstract.
  • Niu, G. H., Sun, X., and Zhang, C. M. [Effect of compound astragalus recipe on lymphocyte subset, immunoglobulin and complements in patients with myasthenia gravia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(4):305-308. View abstract.
  • Omura, Y., Henoch, A., Shimotsuura, Y., Duvvi, H., Kawashima, H., and Ohki, M. Severe asthma with markedly increased asbestos of 2 types & TXB2, and markedly reduced acetylcholine, DHEA & drug uptake in parts of upper lungs, & similar abnormalities at respiratory & cardiac center of medulla oblongata: complete elimination of this asthma within 15 days using one optimal dose of astragalus & application of strong red light & EMF neutralizer on respiratory centers of abnormal medulla oblongata. Acupunct.Electrother.Res 2009;34(1-2):41-73. View abstract.
  • Pang M, Guo F Sun X Guo L. Effective observation of Astragalus injection for refractory heart failure. China Pharmaceuticals 2000;9(7):44.
  • Park JH, Kim BK, Park MK, and et al. Anti-diabetic activity of herbal drugs. Kor J Pharmacogn 1997;28(2):72-74.
  • Peng, T. Q., Yang, Y. Z., and Kandolf, R. [Effect and mechanism of Astragalus membranaceus on coxsackie B3 virus RNA in mice]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1994;14(11):664-666. View abstract.
  • Qin L. Therapeutic effect observation of Chinese and western medicine in the treatment of congestive heart failure. Journal of Shaanxi College of Traditional Chinese Medicine 2000;23(4):46-47.
  • Qu, X. L., Dai, Q., Qi, Y. H., Tang, Y. H., Xu, D. H., Wu, Z. H., and Wang, X. X. [Effects of Astragalous Injection on oxidative stress status in maintenance hemodialysis patients]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2008;6(5):468-472. View abstract.
  • Qu, Z. L., Dong, H., and Wang, S. D. [Effects of astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary bypass]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2009;29(4):313-316. View abstract.
  • Shen, P., Liu, M. H., Ng, T. Y., Chan, Y. H., and Yong, E. L. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARalpha, PPARgamma, and adipocyte differentiation in vitro. J Nutr 2006;136(4):899-905. View abstract.
  • Shi, F. S., Yang, Z. G., and Di, G. P. [Effect of Astragalus saponin on vascular endothelial cell and its function in burn patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2001;21(10):750-751. View abstract.
  • Shi, H. M., Dai, R. H., and Fan, W. H. [Intervention of lidocaine and Astragalus membranaceus on ventricular late potentials]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Integrated Traditional and Western Medicine) 1994;14(10):598-600. View abstract.
  • Shimizu, N., Tomoda, M., Kanari, M., and Gonda, R. An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus. Chem.Pharm Bull.(Tokyo) 1991;39(11):2969-2972. View abstract.
  • Shon, Y. H. and Nam, K. S. Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. Phytother.Res 2003;17(9):1016-1020. View abstract.
  • Song, J. Y., Meng, L. Q., and Li, X. M. [Therapeutic application and prospect of Astragalus membranaceus and Angelica sinensis in treating renal microvascular lesions]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(9):859-861. View abstract.
  • Song, J., Meng, L., Li, S., Qu, L., and Li, X. A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. Vascul.Pharmacol. 2009;50(5-6):185-193. View abstract.
  • Su X, Liu C. Clinical observation of injection Huangqi treating 46 patients with heart failure. Journal of Heze Medical College 2002;14(3):21.
  • Su, L., Mao, J. C., and Gu, J. H. [Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2007;5(3):272-275. View abstract.
  • Su, Y. C., Lin, C. J., Chen, K. T., Lee, S. M., Lin, J. S., Tsai, C. C., Chou, Y., and Lin, J. G. Effects of huangqi jianzhong tang on hematological and biochemical parameters in judo athletes. Acta Pharmacol.Sin. 2001;22(12):1154-1158. View abstract.
  • Sun Y, Chang Y, and Yu G. Effect of Fu-Zheng therapy in the management of malignant diseases. Chin Med J 1981;61:97-101.
  • Sun, Y. and Yang, J. [Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2004;24(1):57-58. View abstract.
  • Taixiang, W., Munro, A. J., and Guanjian, L. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane.Database.Syst.Rev. 2005;(1):CD004540. View abstract.
  • Tang, L. L., Sheng, J. F., Xu, C. H., and Liu, K. Z. Clinical and experimental effectiveness of Astragali compound in the treatment of chronic viral hepatitis B. J Int Med Res 2009;37(3):662-667. View abstract.
  • Tian L, Ai J Deng C. Clinical observation of Huangqi injection combined with captopril for the treatment of 46 cases with chronic pulmonary heart failure. Shanghai Medical & Pharmaceutical Journal 1997;11:16.

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