Skip to content

    Colorectal Cancer Health Center

    Font Size

    Short Course of Radiation Fights Rectal Cancer

    Study Shows Five Days of Treatment Cuts Risk of Cancer’s Return

    Standard Treatment in the U.S. continued...

    "Waiting lets the tumor shrink" so less surrounding tissue needs to be removed, he says. Also, the longer course of radiation means a lower dose is given at each visit, he says.

    "We're concerned the higher dose [used in The Netherlands] may lead to more long-term side effects such as bowel dysfunction that requires more surgery to fix the injured tissue," Willett says.

    Nonetheless, "this is an important trial because it has stimulated a lot of other trials looking at different radiation schedules. It's getting us closer to the optimal way to treating locally advanced rectal cancer," he says.

    New Surgical Technique

    Marijnen says the introduction of a new surgical technique that is being used more and more in both the U.S. and Europe prompted the study.

    In the past, "surgeons pulled out just the rectum. Then studies showed total mesorectal excision (TME), in which surgeons remove the whole rectum plus the fat around it, reduces the risk of local recurrence even further," she says.

    However, the impact of giving radiation prior to TME had not been examined, Marijnen says.

    "These results demonstrate that good surgery absolutely is necessary and then radiotherapy can definitely add to the prevention of local recurrence," she says.

    Willett says the findings "show the need for continuing education so TME is integrated into standard practice."

    Radiation therapy does carry risks, chiefly temporary fatigue and transient skin reactions similar to sunburns during treatment. Later, there is a very small risk of secondary cancer or radiation-induced heart or lung disease.

    This study was presented at a medical conference. The findings should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.

    1 | 2

    Today on WebMD

    Colorectal cancer cells
    The right diagnosis is the most important factor.
    man with a doctor
    Our health check will steer you in the right direction.
    sauteed cherry tomatoes
    Fight cancer one plate at a time.
    bladder cancer x-ray
    Do you know the warning signs?
    Colon vs Rectal Cancer
    New Colorectal Treatments
    can lack of sleep affect your immune system
    Cancer Facts Quiz
    Virtual Colonoscopy
    Picture of the Colon
    Vitamin D