Oxykrinin, Secretina, Sécrétine.<br/><br/>


Overview Information

Secretin is a hormone produced by the digestive tract. It is used as a medicine. Some secretin products are taken from pigs. Others are made in the laboratory.

Secretin is used to treat autism. Two dosage forms are available. Secretin is either placed under the tongue or given by IV (intravenously).

Secretin is also given by IV for pervasive developmental disorder (PDD), pancreatitis and other pancreas problems, overactive parathyroid gland, duodenal ulcers, bleeding in the stomach and intestines, and heart failure. It is also given by IV for preventing stress ulcers and for diagnosing a rare digestive tract condition called Zollinger-Ellison syndrome.

How does it work?

Secretin is a hormone that is produced by the digestive tract. It stimulates the release of bicarbonate and water from the pancreas to aid digestion.


Uses & Effectiveness?

Likely InEffective for

  • Autism and pervasive developmental disorder (PDD). The use of secretin for autism is controversial. Some people have reported they have seen an improvement in stomach and intestinal function, social and behavioral abilities, and language skills after single intravenous doses of secretin. But most of the evidence shows that secretin, both lab-made and derived from pigs, doesn’t improve autism or pervasive developmental disorder when given in single or repeated doses.

Insufficient Evidence for

  • Stress ulcers in severe trauma or disease. Developing evidence suggests that secretin might help prevent stress ulcers.
  • Pancreatitis. There is some evidence that secretin might help symptoms of ongoing pancreatitis.
  • Intestinal ulcers.
  • Digestive tract bleeding.
  • Heart failure.
  • Other conditions.
More evidence is needed to rate the effectiveness of secretin for these uses.

Side Effects

Side Effects & Safety

Secretin is available as a prescription product that is used intravenously. Intravenous products are safe when used appropriately. Common side effects of secretin include flushing of the face, neck, and chest immediately after a dose. Less common side effects are vomiting, diarrhea, fainting, blood clot, fever, and rapid heartbeat. Some people can have allergic reactions including hives, redness of the skin, and a life-threatening allergic reaction (anaphylaxis).

There isn’t enough information to know whether the under-the-tongue dosage form of secretin is safe to use.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of secretin during pregnancy and breast-feeding. Stay on the safe side and avoid use.



We currently have no information for SECRETIN Interactions.



The appropriate dose of secretin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for secretin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Coniglio SJ, Lewis JD, Lang C, et al. A randomized, double-blind, placebo-controlled trial of single-dose intravenous secretin as treatment for children with autism. J Pediatr 2001;138:649-55. View abstract.
  • Horvath K, Stefatos G, Sokolski KN. Improved social and language skills after secretin administration. J Assoc Acad Minor Phys 1998;9:9-15. View abstract.
  • Jowell PS, Robuck-Mangum G, Mergener K, et al. A double-blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin. Aliment Pharmacol Ther 2000;14:1679-84.. View abstract.
  • Lightdale JR, Hayer C, Duer A, et al. Effects of intravenous secretin on language and behavior of children with autism and gastrointestinal symptoms: a single-blinded, open-label pilot study. Pediatrics 2001;108:90. View abstract.
  • Mulvihill SJ, Debas HT. Regulatory peptides in the gut. In: Greenspan FS, Strewler GJ, Eds. Basic & Clinical Endocrinology. 5th ed. Stamford, CT: Appleton & Lange, 1997:581.
  • Roberts W, Weaver L, Brian J, et al. Repeated doses of porcine secretin in the treatment of autism: A randomized, placebo-controlled trial. Pediatrics 2001;107:e71.
  • Sandler AD, Sutton KA, DeWeese J, et al. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. N Engl J Med 1999;341(24):1801-6. View abstract.
  • Secretin for the treatment of autism. Pharmacist's Letter/Prescriber's Letter 1998;14(12):141212.
  • Spilker G, Theisinger W, Bader, Seidel G. [Long-acting secretin for the prevention of stress ulcers in surgery]. Nouv Presse Med 1982;11: 267-9. View abstract.
  • Theisinger W, Spilker G, Bader M . [Prevention of stress ulcers with synthetic depot secretin]. Med Klin 1981;76:291-3. View abstract.
  • Tympner F, Rosch W. The treatment of chronic recurrent pancreatitis with depot secretin-a preliminary report. Hepatogastroenterology 1986;33:159-62. View abstract.

Vitamins Survey

Have you ever purchased SECRETIN?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for SECRETIN

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.