SECRETIN

OTHER NAME(S):

Oxykrinin, Secretina, Sécrétine.<br/><br/>

Overview

Overview Information

Secretin is a hormone produced by the digestive tract. It is used as a medicine. Some secretin products are taken from pigs. Others are made in the laboratory.

Secretin is used to treat autism. Two dosage forms are available. Secretin is either placed under the tongue or given by IV (intravenously).

Secretin is also given by IV for pervasive developmental disorder (PDD), pancreatitis and other pancreas problems, overactive parathyroid gland, duodenal ulcers, bleeding in the stomach and intestines, and heart failure. It is also given by IV for preventing stress ulcers and for diagnosing a rare digestive tract condition called Zollinger-Ellison syndrome.

How does it work?

Secretin is a hormone that is produced by the digestive tract. It stimulates the release of bicarbonate and water from the pancreas to aid digestion.

Uses

Uses & Effectiveness?

Likely InEffective for

  • Autism and pervasive developmental disorder (PDD). The use of secretin for autism is controversial. Some people have reported they have seen an improvement in stomach and intestinal function, social and behavioral abilities, and language skills after single intravenous doses of secretin. But most of the evidence shows that secretin, both lab-made and derived from pigs, doesn’t improve autism or pervasive developmental disorder when given in single or repeated doses.

Insufficient Evidence for

  • Stress ulcers in severe trauma or disease. Developing evidence suggests that secretin might help prevent stress ulcers.
  • Pancreatitis. There is some evidence that secretin might help symptoms of ongoing pancreatitis.
  • Intestinal ulcers.
  • Digestive tract bleeding.
  • Heart failure.
  • Other conditions.
More evidence is needed to rate the effectiveness of secretin for these uses.

Side Effects

Side Effects & Safety

Secretin is available as a prescription product that is used intravenously. Intravenous products are safe when used appropriately. Common side effects of secretin include flushing of the face, neck, and chest immediately after a dose. Less common side effects are vomiting, diarrhea, fainting, blood clot, fever, and rapid heartbeat. Some people can have allergic reactions including hives, redness of the skin, and a life-threatening allergic reaction (anaphylaxis).

There isn’t enough information to know whether the under-the-tongue dosage form of secretin is safe to use.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of secretin during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for SECRETIN Interactions.

Dosing

Dosing

The appropriate dose of secretin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for secretin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Falandysz, J. [Selenium in selected species of mushrooms from Poland]. Rocz.Panstw.Zakl.Hig. 2003;54(3):249-254. View abstract.
  • Hajicek-Dobberstein, S. Soma siddhas and alchemical enlightenment: psychedelic mushrooms in Buddhist tradition. J Ethnopharmacol. 1995;48(2):99-118. View abstract.
  • Michelot, D. and Melendez-Howell, L. M. Amanita muscaria: chemistry, biology, toxicology, and ethnomycology. Mycol.Res 2003;107(Pt 2):131-146. View abstract.
  • Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. Cutis 1993;51(1):41-42. View abstract.
  • Poljacki, M., Paravina, M., Jovanovic, M., Subotic, M., and Duran, V. [Contact allergic dermatitis caused by plants]. Med Pregl. 1993;46(9-10):371-375. View abstract.
  • Zidorn, C., Johrer, K., Ganzera, M., Schubert, B., Sigmund, E. M., Mader, J., Greil, R., Ellmerer, E. P., and Stuppner, H. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. J Agric.Food Chem. 4-6-2005;53(7):2518-2523. View abstract.
  • Aberer, W. Occupational dermatitis from organically grown parsnip (Pastinaca sativa L.). Contact Dermatitis 1992;26(1):62. View abstract.
  • Bang, Pedersen N. and Pla Arles, U. B. Phototoxic reaction to parsnip and UV-A sunbed. Contact Dermatitis 1998;39(2):97. View abstract.
  • Spilker G, Theisinger W, Bader, Seidel G. [Long-acting secretin for the prevention of stress ulcers in surgery]. Nouv Presse Med 1982;11: 267-9. View abstract.
  • Theisinger W, Spilker G, Bader M . [Prevention of stress ulcers with synthetic depot secretin]. Med Klin 1981;76:291-3. View abstract.
  • Tympner F, Rosch W. The treatment of chronic recurrent pancreatitis with depot secretin-a preliminary report. Hepatogastroenterology 1986;33:159-62. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.