ANGEL'S TRUMPET

OTHER NAME(S):

Brugmansia suaveolens, Datura sauveolens, Devil's Trumpet, Floripondio, Stramoine Inoffensive, Stramoine Parfumée, Trompeta de Ángel, Trompette des Anges, Trompette du Jugement.<br/><br/>

Overview

Overview Information

Angel's trumpet is a plant. The leaves and flowers are used to make medicines.

Despite serious safety concerns, people use angel's trumpet as a recreational drug to induce hallucinations and euphoria. They also use it to treat asthma.

How does it work?

Angel's trumpet contains chemicals that can cause euphoria and hallucinations.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Asthma.
  • Causing euphoria and hallucinations.
  • Other conditions.
More evidence is needed to rate the effectiveness of angel’s trumpet for these uses.

Side Effects

Side Effects & Safety

Angel's trumpet is UNSAFE for everyone. The entire plant is poisonous, but the leaves and seeds contain the most poison. Taking angel’s trumpet can cause confusion, dilated pupils, intense thirst, dry skin, flushing, fever, high or low blood pressure, fast heartbeat, difficulty breathing, hallucinations, nervousness, loss of memory, convulsions, paralysis, coma, and death.

Special Precautions & Warnings:

Angel’s trumpet is UNSAFE for anyone to use, but some people have extra reasons not to use it:

Children: Angel’s trumpet is UNSAFE when taken by mouth. Severe poisoning has occurred in children who ate angel’s trumpet accidentally and in teenagers who used angel's trumpet as a recreational drug.

Pregnancy and breast-feeding: Angel’s trumpet is UNSAFE when taken by mouth. The entire plant is considered poisonous. Don’t use it, especially if you are pregnant or breast-feeding.

Congestive heart failure (CHF): Angel's trumpet might cause rapid heartbeat and make CHF worse. Don’t use it.

Constipation: Angel's trumpet might make constipation worse. Don’t use it.

Down syndrome: People with Down syndrome might be especially sensitive to the dangerous side effects of angel’s trumpet. Don’t use it.

Esophageal reflux: Esophageal reflux is a condition in which stomach juices back up into the tube that connects the mouth and the stomach (esophagus). Angel's trumpet might make this condition worse because it can delay stomach emptying. Don’t use it.

Fever: Angel's trumpet might make fever worse. Don’t use it.

Stomach ulcer: Angel's trumpet might delay stomach emptying and make stomach ulcers worse. Don’t use it.

Narrow-angle glaucoma: Angel's trumpet might raise the pressure inside the eye. This could make narrow-angle glaucoma worse. Don’t use it.

Conditions that block the gastrointestinal tract such as atony, paralytic ileus, and stenosis: Angel's trumpet might make these conditions worse. Don’t use it.

Rapid heartbeat (tachycardia): Angel's trumpet might cause make tachycardia worse. Don’t use it.

Ulcerative colitis: Angel’s trumpet might make this condition worse. Don’t use it.

Difficult urination: Angel’s trumpet might make this condition worse. Don’t use it.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Drying medications (Anticholinergic drugs) interacts with ANGEL'S TRUMPET

    Angel's trumpet contains chemicals that cause a drying effect. It also affects the brain and heart. Drying medications called anticholinergic drugs can also cause these effects. Taking angel's trumpet and drying medications together might cause side effects including dry skin, dizziness, low blood pressure, fast heartbeat, and other serious side effects.<br><nb>Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).

Dosing

Dosing

The appropriate dose of Angel's trumpet depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Angel's trumpet. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Ardila, A. and Moreno, C. Scopolamine intoxication as a model of transient global amnesia. Brain Cogn 1991;15(2):236-245. View abstract.
  • Capasso, A. and De, Feo, V. Alkaloids from Brugmansia arborea (L.) Lagerhein reduce morphine withdrawal in vitro. Phytother Res 2003;17(7):826-829. View abstract.
  • Galvez, E., Izquierdo, M. L., Burgos, C., Arias, M. S., Sanz-Aparicio, J., Fonseca, I., Gago, F., Baldominos, G., Lopez, P., and Prieto, J. C. Synthesis and structural, biochemical, and pharmacological study of 3 beta-acyloxy-3 alpha-methoxycarbonyltropane derivatives. J Pharm Sci 1993;82(8):794-798. View abstract.
  • Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52. View abstract.
  • Hassell, L. H. and MacMillan, M. W. Acute anticholinergic syndrome following ingestion of Angel's Trumpet tea. Hawaii Med.J. 1995;54(7):669-670. View abstract.
  • Havelius, U. and Asman, P. Accidental mydriasis from exposure to Angel's trumpet (Datura suaveolens). Acta Ophthalmol.Scand. 2002;80(3):332-335. View abstract.
  • Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466. View abstract.
  • Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382. View abstract.
  • Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459. View abstract.
  • McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196. View abstract.
  • Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21. View abstract.
  • Mobus, U., Felscher, D., and Schulz, K. [Nightshade plants act almost like LSD. Poisoning cases are on the rise]. MMW.Fortschr.Med 11-18-1999;141(46):46-48. View abstract.
  • Nencini, C., Cavallo, F., Bruni, G., Capasso, A., De, Feo, V, De Martino, L., Giorgi, G., and Micheli, L. Affinity of Iresine herbstii and Brugmansia arborea extracts on different cerebral receptors. J Ethnopharmacol 5-24-2006;105(3):352-357. View abstract.
  • Niess, C., Schnabel, A., and Kauert, G. [Angel trumpet: a poisonous garden plant as a new addictive drug?]. Dtsch Med Wochenschr. 12-3-1999;124(48):1444-1447. View abstract.
  • Paetzold, W., Schneider, U., Emrich, H. M., and Oehlschlager, P. [Angel trumpets: case report of drug-induced psychosis caused by Brugmansia insigniis]. Psychiatr.Prax. 1999;26(3):147-148. View abstract.
  • Pitta-Alvarez, S. I., Spollansky, T. C., and Giulietti, A. M. The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida. Enzyme Microb.Technol. 2-1-2000;26(2-4):252-258. View abstract.
  • Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219. View abstract.
  • Thompson, P. E., Steer, D. L., Aguilar, M. I., and Hearn, M. T. Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation. Bioorg.Med Chem Lett 10-6-1998;8(19):2699-2704. View abstract.
  • Van, der Donck, I, Mulliez, E., and Blanckaert, J. Angel's trumpet (Brugmansia arborea) and mydriasis in a child--a case report. Bull.Soc.Belge Ophtalmol. 2004;(292):53-56. View abstract.
  • Anon. Plant Poisonings - New Jersey. MMWR Morb Mortal Wkly Rep 1981;30:65-7.
  • Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  • Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. View abstract.
  • Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9. View abstract.
  • Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. View abstract.
  • McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  • Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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