Cosse de Soja, Cosse de Soya, Daidzein, Daidzéine, Dolichos soja, Edamame, Estrogène Végétal, Fermented Soy, Fève de Soja, Fève de Soya, Fibre de Soja, Fibre de Soya, Frijol de Soya, Genestein, Genistein, Génistéine, Glycine gracilis, Glycine hispida, Glycine max, Glycine soja, Haba Soya, Haricot de Soja, Haricot de Soya, Hydrolyzed Soy Protein, Isoflavone, Isoflavone de Soja, Isoflavone de Soya, Isolated Soy Protein, Isolated Soybean Protein, Lait de Soja, Lait de Soya, Legume, Miso, Natto, Phaseolus max, Phytoestrogen, Phyto-œstrogène, Plant Estrogen, Protéine de Haricot de Soja Isolée, Protéine de Haricot de Soya Isolée, Protéine de Soja, Protéine de Soya, Protéine de Soja Isolée, Protéine de Soya Isolée, Shoyu, Soja, Soja hispida, Soja max, Sojabohne, Soy Bean, Soy Fiber, Soy Germ, Soy Isoflavone, Soy Isoflavones, Soy Milk, Soy Polysaccharide, Soy Protein, Soy Protein Isolate, Soya, Soya Bean, Soja Fermenté, Soya Fermenté, Soybean, Soybean Curd, Soybean Isoflavone, Soybean Isoflavones, Tempeh, Texturized Vegetable Protein, Tofu, Touchi.<br/><br/>
Overview InformationSoy comes from soybeans. The beans can be processed into soy protein, which is a powder; soymilk, which is a beverage that may or may not be fortified with extra calcium from the soybeans; or soy fiber, which contains some of the fibrous parts of the bean.
Soy is taken by mouth for high cholesterol, high blood pressure, and preventing diseases of the heart and blood vessels. It is also used for type 2 diabetes and kidney disease associated with diabetes during pregnancy, Alzheimer's disease, asthma, as well as preventing weak bones (osteoporosis), preventing joint pain and stiffness in people with arthritis, and slowing the progression of kidney disease. Soy is also taken by mouth to prevent different kinds of cancer.
Soy is also taken by mouth for treating constipation, diarrhea, Crohn's disease, hepatitis C, irritable bowel syndrome, metabolic syndrome, fibromyalgia, weight loss, enlarged prostate, as well as decreasing protein in the urine of people with kidney disease, improving memory and mental function, improving muscle strength, and treating muscle soreness caused by exercise.
Women take soy by mouth for breast pain, preventing hot flashes after breast cancer, menopausal symptoms, premenstrual syndrome (PMS), disorders of the ovary such as polycystic ovary syndrome, and migraine headaches during menstruation.
Soy is used as a milk substitute in infant feeding formulas, and as an alternative to cow's milk. It is fed to infants who are unable to process the sugar galactose, who are lactose intolerance, who have a condition called hereditary lactase deficiency, or who have infant colic.
Soy is applied to the skin to improve photo-aged skin or wrinkled skin.
Soy is applied inside the vagina to treat vaginal swelling due to decreased lubrication and thinning vaginal tissue (vaginal atrophy).
In foods, soybeans are eaten boiled or roasted. Soy flour is used as an ingredient in foods, beverages, and condiments.
The active ingredients in soy are called isoflavones. A study of the quality of commercially available soy supplements suggests that less than 25% of products contain within 90% of labeled isoflavone content. Paying more for a product doesn't necessarily guarantee that the content shown on the label is accurate.
How does it work?Soy contains "isoflavones" which are changed in the body to "phytoestrogens," which are similar to the hormone estrogen.
Uses & Effectiveness
Possibly Effective for
- Breast cancer. Eating a high-soy diet is linked to a slightly reduced risk of developing breast cancer in some but not all women. Asian women who eat a high-soy diet seem to have a lower risk of breast cancer than those who eat less soy. But most research shows no benefit in Western-culture women. It's possible that women of Western culture do not eat enough soy to see any benefit. The effects of soy on breast cancer risk also seem to vary depending on a woman's age and menopausal status. Women who eat a high-soy diet during adolescence seem to have a reduced risk of breast cancer. This suggests that early exposure to soy might protect against breast cancer later in life. In women already diagnosed with breast cancer, eating a high soy diet is linked to a reduced risk of breast cancer recurrence. But there is no reliable evidence that taking a soy isoflavones supplement reduces breast cancer growth.
- Diabetes. Most research suggests that consuming soy products containing soy protein, soy fiber, or fermented soy reduces blood sugar levels in people with diabetes.
- Diarrhea. Feeding infants formula supplemented with soy fiber, alone or together with rehydration solution, seems to reduce the duration of diarrhea compared to cow's milk formula or rehydration solution alone. However, in some studies formula supplemented with soy was no more beneficial than cow's milk formula. In adults, early evidence suggests that taking soy fiber does not decrease the incidence of diarrhea.
- Trouble digesting the sugar galactose (galactosemia). Feeding a soy-based formula to infants who have galactosemia seems to be helpful.
- Trouble digesting the sugar lactose (hereditary lactase deficiency). Feeding a soy-based formula to infants who have hereditary lactase deficiency seems to be helpful.
- High cholesterol. Eating soy protein in place of other dietary protein or using soy fiber products seems to slightly reduce total cholesterol and "bad cholesterol" (low-density lipoprotein (LDL) cholesterol). Soy protein that contains higher amounts of an ingredient called isoflavones might work better than soy protein with little or no isoflavones. Also, soy might work better in people with high cholesterol that is more severe. Supplements containing purified soy isoflavones don't seem to work. Soy doesn't seem to lower triglycerides. Also, most research shows that soy doesn't increase "good cholesterol" (high-density lipoprotein (HDL) cholesterol).
- High blood pressure. Most research shows that eating soy protein can reduce systolic blood pressure (the top number in a blood pressure reading) by about 4-8 mmHg and diastolic blood pressure (the bottom number) by about 3-5 mmHg in people with slightly high blood pressure.
- Irritable bowel syndrome (IBS). Some research suggests that taking soy isoflavones can improve symptoms of IBS, such as stomach pain.
- Kidney disease. Taking soy protein by mouth seems to reduce protein in the urine in people with kidney disease. It also seems to reduce levels of certain nutrients and waste products, such as phosphorus and creatinine. These molecules can build up in the blood of people with long-term kidney disease.
- Trouble digesting the sugar lactose (lactose intolerance). Feeding a soy-based formula to infants who have lactose intolerance seems to be helpful.
- Menopausal symptoms. Eating soy protein or taking concentrated soy isoflavone extract seems to help hot flashes caused by menopause in some people. Taking soy products providing 100-200 mg of isoflavones in two or three divided doses per day might work better than taking lower or less frequent doses. In addition, using products that contain at least 15 mg of the specific isoflavone called genistein seem to work better than products that provide less genistein. Taking soy also seems to improve depression, blood sugar levels and body weight in women after menopause. It's unclear if soy reduces vaginal dryness or itching that is associated with menopause. Soy does not seem to help hot flashes in women with breast cancer.
- Metabolic syndrome (a condition that increases risk for diabetes and heart disease). Most research shows that consuming soy products containing soy protein helps lower blood sugar levels in people with metabolic syndrome. Also, eating a soy nut diet or a soy protein diet appears to reduce blood sugar and decrease "bad" cholesterol (low-density lipoprotein (LDL) cholesterol) in postmenopausal women with metabolic syndrome; however, the soy nut diet seems to work better than the soy protein diet.
- Osteoporosis. Most evidence suggests that soy protein or soy extract can increase bone mineral density (BMD) or slow BMD loss in women near or beyond menopause. It appears that soy products need to contain at least 75 mg of an ingredient called isoflavones in order to work. Soy might also reduce the risk of fractures in some women. Soy does not seem to affect BMD in younger women.
Possibly Ineffective for
- Enlarged prostate (benign prostatic hyperplasia or BPH). Taking isoflavones isolated from soy doesn't seem to improve urination or other symptoms in people with an enlarged prostate.
- Hot flashes related to breast cancer. Research shows that drinking a beverage containing soy or taking tablets containing soy extract does not reduce hot flashes in breast cancer survivors.
- Colorectal cancer. Research suggests that taking soy protein does not reduce the progression of colorectal cancer.
- Muscle soreness after exercise. Taking soy isoflavone extract by mouth before exercising does not seem to prevent muscle soreness.
- Fibromyalgia. Drinking a soy protein shake containing soy isoflavones does not appear to improve physical function or symptoms of depression in people with fibromyalgia.
Insufficient Evidence for
- Alzheimer's disease. Early research suggests that taking soy isoflavones does not improve brain function in patients with Alzheimer's disease.
- Asthma. Early evidence suggests that people with asthma who eat soy foods have increased lung function, but taking supplements containing an ingredient in soy called isoflavones doesn't appear to improve lung function or reduce asthma episodes in adults or children with poorly controlled asthma.
- Heart disease. Some evidence suggests that postmenopausal women, but not men or pre-menopausal women, who eat a lot of soy in their diet might have a reduced risk of stroke, heart attack, or heart disease-related death.
- Mental function. There is conflicting evidence about the effect of soy on mental function. Some evidence suggests that eating more soy improves short-term and long-term memory. However, other research suggests that soy does not improve mental function, including memory. Some soy formulations might work better than others.
- Colic. Early research shows that feeding infants a soy-based formula might reduce the duration of colic symptoms in infants who have trouble digesting cow's milk. But higher-quality research suggests that feeding infants a soy-based formula does not improve the duration of crying in infants with colic. Also, soy-based formula doesn't seem to improve crying compared to the drug dicyclomine.
- Crohn's disease. Research suggests that taking soy by mouth, along with standard treatment, increases bowel movements and improves symptoms, such as fatigue and body weight, in people with Crohn's disease.
- Kidney disease in people with diabetes. Research shows that eating soy protein in place of animal protein as part of the diet might help prevent or treat kidney disease in people with diabetes. But some early research shows that drinking soy milk doesn't help.
- Cancer of the lining of the uterus (endometrial cancer). Eating more soy seems to lower the risk of endometrial cancer. Endometrial cancer is less common in Japan, China, and other Asian countries where the usual diet is low in calories and high in soy and whole grain foods, vegetables, and fruits. It's too early to know if soy supplements affect endometrial cancer risk.
- Stomach cancer. Eating more foods that contain soy might reduce the risk of getting stomach cancer. However, it is not known if soy supplements affect stomach cancer risk. Also, eating one type of fermented soy, called miso, might increase the risk of stomach cancer in men.
- Diabetes during pregnancy. Research suggests that when women with diabetes during pregnancy eat soy their blood sugar levels are reduced. Also, there is some protection against illnesses in the newborn. Eating soy does not seem to prevent the need for a caesarean section or the risk of early labor in women with diabetes during pregnancy.
- Hepatitis C. Early research suggests that taking soy protein reduces the buildup of fat in the liver and lowers biomarkers linked with liver damage in patients with hepatitis C.
- Lung cancer. Men and women who consume a higher amount of dietary phytoestrogens, such as isoflavones from soy, seem to be less likely to develop lung cancer than people who consume smaller amounts. Soy seems to prevent lung cancer more in men than women. However, some research suggests that only non-smokers, not smokers, who eat soy have a lower risk of developing lung cancer.
- Breast pain (mastalgia). Drinking soymilk might reduce monthly breast pain in some women.
- Migraine. Research suggests that taking a combination of soy isoflavones, dong quai, and black cohosh reduces the frequency of migraines associated with menstruation.
- Muscle strength. Research suggests that taking soy protein can increase lean tissue mass in people participating in resistance training. Other research suggests that consuming a specific soy protein product (Supro) can increase body mass and strength and reduce fatigue in athletes. However,conflicting research shows that soy protein might not improve strength.
- Osteoarthritis. Early research shows that taking soy protein can improve motion, pain, and quality of life in people with osteoarthritis. However, taking milk-based protein also seems to have these effects.
- An ovary disorder known as polycystic ovary syndrome (PCOS). Women with PCOS have higher levels of cholesterol in the blood, higher levels of male hormones, and problems regulating blood sugar. Some research suggests that taking soy isoflavones improves the regulation of blood sugar and hormone levels in women with this condition. But taking soy does not seem to improve cholesterol levels.
- Premenstrual syndrome (PMS). Research suggests that taking soy protein for two menstrual cycles can reduce cramps and swelling associated with PMS.
- Prostate cancer. Research regarding the effect of soy on prostate cancer risk is conflicting. Men who eat an Asian diet, which contains 10 times more soy than the average American diet, seem to have a lower risk of prostate cancer. However, it is unclear whether it is the soy in the diet of Asian men or other factors (such as genetic differences or differences in dietary fat) that protect against prostate cancer. Some research shows that taking soy protein can reduce the risk of prostate cancer in at-risk men. However, there is conflicting evidence about whether soy can affect the progression of prostate cancer. Soy protein doesn't seem to reduce hot flashes in prostate cancer patients.
- Rheumatoid arthritis. Early research suggests that consuming a liquid diet containing soy protein does not improve pain, stiffness, or joint swelling in people with rheumatoid arthritis.
- Thyroid cancer. Diets that include plenty of soy seem to be linked to a reduced risk of thyroid cancer.
- Thinning vaginal tissue (vaginal atrophy). Applying a vaginal gel containing soy extract seems to reduce vaginal dryness and pain and improve vaginal tissue in postmenopausal women with symptoms of vaginal atrophy.
- Weight loss. Some research suggests that eating a soy-based, low-calorie diet can reduce weight in obese and overweight people more than a low-calorie diet alone. Eating foods containing soy fiber might also improve weight loss. Replacing meat protein with soy protein in the diet might improve weight loss in women, although conflicting data exists. Supplementing with soy-based meal replacements doesn't seem to improve weight loss or prevent weight gain. Soy protein doesn't seem to improve weight loss when eaten as part of a free-choice diet.
- Wrinkled skin. Consuming soy isoflavones or applying a moisturizer containing soy seems to improve the elasticity of skin and the appearance of fine wrinkles.
- Other conditions.
Side Effects & SafetyConsuming foods containing soy protein or taking soy protein products is LIKELY SAFE. Taking dietary supplements with soy extracts is POSSIBLY SAFE when used short-term (up to 6 months). Soy can cause some mild stomach and intestinal side effects such as constipation, bloating, and nausea. It can also cause allergic reactions involving rash, itching, and anaphylaxis in some people. Some people might experience tiredness. Soy might also affect thyroid function. However, this seems to occur primarily in people who are iodine deficient.
Long-term use of high doses of soy extract is POSSIBLY UNSAFE. There is some concern that taking high doses might cause abnormal tissue growth in the uterus. However, eating large amounts of soy does not seem to have this effect.
Special Precautions & Warnings:Pregnancy and breast-feeding: Soy protein is LIKELY SAFE to be used during pregnancy and breast-feeding when consumed in amounts normally found in food. However, soy may be POSSIBLY UNSAFE when used during pregnancy in medicinal amounts. Higher doses during pregnancy might harm development of the baby. Not enough is known about the safety of higher doses during breast-feeding. Stay on the safe side and avoid larger doses.
Children: Soy is LIKELY SAFE for children when used in amounts commonly found in food or infant formula. Using soy formula does not seem to cause health or reproductive problems later in life. However, soymilk that is not designed for infants should not be used as a substitute for infant formula. Regular soymilk could lead to nutrient deficiencies.
Soy is POSSIBLY UNSAFE when used as an alternative to cow's milk in children who are allergic to cow's milk. Although soy protein-based infant formulas are often promoted for children with milk allergy, these children are often allergic to soy as well.
Don't give children soy in amounts larger than what is found in food or formula. Researchers don't know whether soy is safe for children at higher doses.
Hay fever (allergic rhinitis): People with hay fever are more likely to be allergic to soy hulls.
Asthma: People with asthma are more likely to be allergic to soy hulls. Avoid using soy products.
Breast cancer: The effects of soy in people with breast cancer are unclear. Some research finds that soy might "feed" certain breast cancers because it can act like estrogen. Other studies have found that soy seems to protect against breast cancer. The difference in effects might have something to do with the amount taken. Because there isn't enough reliable information about the effects of soy in women with breast cancer, a history of breast cancer, or a family history of breast cancer, it's best to avoid using soy supplements until more is known.
Cystic fibrosis: Soymilk can interfere with the way children with cystic fibrosis process protein. Don't give these children soy products.
Diabetes: Soy might increase the risk of blood sugar levels becoming too low in people with diabetes who are taking medication to control blood sugar.
Endometrial cancer: Long-term use of concentrated soy isoflavone tablets might increase the occurrence of precancerous changes in the tissue lining the uterus. However, conflicting evidence exists. Use supplements containing soy isoflavones cautiously if you are at risk for endometrial cancer. Soy foods are likely safe.
Under-active thyroid (hypothyroidism): There is a concern that taking soy might make this condition worse.
Kidney stones: There is some concern that soy products might increase the risk of kidney stones because they contain large amounts of a group of chemicals called oxalates. Oxalates are the main ingredient in kidney stones. Another concern is that people with serious kidney disease aren't able to process some of the chemicals in soy. This could lead to dangerously high levels of these chemicals. If you have a history of kidney stones, avoid taking large amounts of soy.
Milk allergy: Children who are very allergic to cow's milk might also be sensitive to soy products. Use soy products with caution.
Kidney failure: Soy contains a chemical called phytoestrogens. Very high levels of phytoestrogens can be toxic. People with kidney failure who use soy products might be at risk for blood levels of phytoestrogens becoming too high. If you have kidney failure, avoid taking large amounts of soy.
Urinary bladder cancer: Soy products might increase the chance of getting bladder cancer. Avoid soy foods if you have bladder cancer or a high risk of getting it (family history of bladder cancer).
Do not take this combination
Medications for depression (MAOIs) interacts with SOY
Fermented soy products such as tofu and soy sauce contain tyramine. Tyramine is an amino acid that is involved in blood pressure regulation. Tyramine is broken down by monoamine oxidase. Some medications for depression (MAOIs) can decrease the breakdown of tyramine. Consuming more than 6 mg of tyramine while taking one of these medications can increase the risk of serious side effects such as blood pressure getting too high. The amount of tyramine in fermented soy products is usually small, often less than 0.6 mg per serving; however, there can be variation depending on the specific product used, storage conditions, and length of storage. Storing one brand of tofu for a week can increase tyramine content from 0.23 mg to 4.8 mg per serving. If you take one of these medications, avoid fermented soy products that contain high amounts of tyramine.<br><nb>Some of these medications include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Be cautious with this combination
Antibiotic drugs interacts with SOY
Antibiotics are used to reduce harmful bacteria in the body. Antibiotics can also reduce friendly bacteria in the intestines. Friendly bacteria in the intestines seem to help increase the effectiveness of soy. By reducing the number of bacteria in intestines antibiotics might decrease the effectiveness of soy. But it is too soon to know if this interaction is a big concern.
Estrogens interacts with SOY
Large amounts of soy might have some of the same effects as estrogen. But soy isn't as strong as estrogen pills. Taking soy along with estrogen pills might decrease the effects of estrogen pills.<br /><br /> Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Tamoxifen (Nolvadex) interacts with SOY
Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. Soy seems to also affect estrogen levels in the body. By affecting estrogen in the body, soy might decrease the effectiveness of tamoxifen (Nolvadex). Do not take soy if you are taking tamoxifen (Nolvadex).
Warfarin (Coumadin) interacts with SOY
Warfarin (Coumadin) is used to slow blood clotting. Soy has been reported to decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. It is unclear why this interaction might occur. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Be watchful with this combination
Medications changed by the liver (Cytochrome P450 2C9 (CYP 2C9) substrates) interacts with SOY
Some medications are changed and broken down by the liver. Soy might increase how quickly the liver breaks down some medications. But it is too soon to know if this interaction occurs in all people or if it affects how well the medication works.<br /><br /> Some medications changed by the liver include carvedilol (Coreg), fluvastatin (Lescol), losartan (Cozaar), phenytoin (Dilantin), and many others.
The following doses have been studied in scientific research:
ADULTS: BY MOUTH:
- For type 2 diabetes:
- Touchi extract 300 mg three times daily for 3-6 months. Touchi is a traditional Chinese food prepared from soybeans.
- Fibrous soy hulls 26 grams daily for 4 weeks. Single doses of soy fiber 7-10 grams have also been used.
- 30 grams of soy protein, containing 132 mg of phytoestrogens, daily for up to 12 weeks.
- For high cholesterol: 20-50 grams per day of soy protein.
- For high blood pressure. 18-66 grams of soy protein, containing 34-143 mg of isoflavones, daily for up to 12 weeks has been used. Also, 4.5 grams of black soy peptide daily for 8 weeks has also been used.
- For irritable bowel syndrome. Soy containing 40 mg isoflavones daily for 6 weeks has been used.
- For protein in the urine of people with kidney disease: a diet limited to 700-800 mg/kg soy protein daily has been used.
- For menopausal symptoms such as hot flashes:
- 15-60 grams per day of soy protein providing 34-80 mg isoflavones.
- concentrated soy isoflavone extracts providing 35-200 mg/day of isoflavones.
- Genistein, a soy isoflavone: 54 mg per day.
- For menopausal symptoms such as depression: 100 mg of soy containing 50 mg of isoflavones has been used along with sertraline 50 mg daily.
- To reduce body weight during menopause: Soy isoflavones <100 mg daily for up to 6 months have been used.
- For metabolic syndrome. 30 grams of soy nuts per day as part of a diet high in fruit and vegetables for 8 weeks has been used.
- For preventing weak bones (osteoporosis): 40 grams per day soy protein containing 2-2.25 mg isoflavones per gram has been used for 3-6 months. Soy extract 1 gram containing 80 mg of isoflavones has been used for one year.
- For diarrhea in infants: Soy fiber-fortified formula containing 18-20 grams of soy protein per liter has been used.
- Lovati, M. R., Manzoni, C., Canavesi, A., Sirtori, M., Vaccarino, V., Marchi, M., Gaddi, G., and Sirtori, C. R. Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients. J Clin Invest 1987;80(5):1498-1502. View abstract.
- Lu LJW and Anderson KE. Short half-lives and gender differences of excretion of soya isoflavones in humans. Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease 1996;
- Lu, L. J., Anderson, K. E., Grady, J. J., and Nagamani, M. Effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction. Cancer Epidemiol.Biomarkers Prev. 1996;5(1):63-70. View abstract.
- Lucassen, P. L., Assendelft, W. J., Gubbels, J. W., van Eijk, J. T., van Geldrop, W. J., and Neven, A. K. Effectiveness of treatments for infantile colic: systematic review. BMJ 5-23-1998;316(7144):1563-1569. View abstract.
- Lydeking-Olsen, E., Beck-Jensen, J. E., Setchell, K. D., and Holm-Jensen, T. Soymilk or progesterone for prevention of bone loss--a 2 year randomized, placebo-controlled trial. Eur.J Nutr. 2004;43(4):246-257. View abstract.
- Ma, Y., Chiriboga, D., Olendzki, B. C., Nicolosi, R., Merriam, P. A., and Ockene, I. S. Effect of soy protein containing isoflavones on blood lipids in moderately hypercholesterolemic adults: a randomized controlled trial. J Am.Coll.Nutr. 2005;24(4):275-285. View abstract.
- Mackey, R., Ekangaki, A., and Eden, J. A. The effects of soy protein in women and men with elevated plasma lipids. Biofactors 2000;12(1-4):251-257. View abstract.
- Manonai, J., Songchitsomboon, S., Chanda, K., Hong, J. H., and Komindr, S. The effect of a soy-rich diet on urogenital atrophy: a randomized, cross-over trial. Maturitas 5-20-2006;54(2):135-140. View abstract.
- Matthan, N. R., Jalbert, S. M., Ausman, L. M., Kuvin, J. T., Karas, R. H., and Lichtenstein, A. H. Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects. Am J Clin Nutr 2007;85(4):960-966. View abstract.
- Mclachlan, J. A., Simpson, E., and Martin, M. Endocrine disrupters and female reproductive health. Best.Pract Res Clin Endocrinol.Metab 2006;20(1):63-75. View abstract.
- McVeigh, B. L., Dillingham, B. L., Lampe, J. W., and Duncan, A. M. Effect of soy protein varying in isoflavone content on serum lipids in healthy young men. Am J Clin Nutr 2006;83(2):244-251. View abstract.
- Meinertz, H., Faergeman, O., Nilausen, K., Chapman, M. J., Goldstein, S., and Laplaud, P. M. Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects. Atherosclerosis 1988;72(1):63-70. View abstract.
- Meinertz, H., Nilausen, K., and Faergeman, O. Soy protein and casein in cholesterol-enriched diets: effects on plasma lipoproteins in normolipidemic subjects. Am J Clin Nutr 1989;50(4):786-793. View abstract.
- Meinertz, H., Nilausen, K., and Hilden, J. Alcohol-extracted, but not intact, dietary soy protein lowers lipoprotein(a) markedly. Arterioscler.Thromb.Vasc.Biol. 2-1-2002;22(2):312-316. View abstract.
- Mercer, N. J. H. Effects on human plasma lipids of substituting soybean protein isolate for milk protein in the diet. Nutr Reports Int 1987;35:279-287.
- Messina, M. and Redmond, G. Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a review of the relevant literature. Thyroid 2006;16(3):249-258. View abstract.
- Meyer, B. J., Larkin, T. A., Owen, A. J., Astheimer, L. B., Tapsell, L. C., and Howe, P. R. Limited lipid-lowering effects of regular consumption of whole soybean foods. Ann.Nutr.Metab 2004;48(2):67-78. View abstract.
- Muratori M, Nicoletti I, Vannelli GB, and et al. Genistein induces a G2-M block and apoptosis in human uterine adenocarcinoma cell lines. Endocr Relat Cancer 1997;4:203-218.
- Nagata, C., Takatsuka, N., Kurisu, Y., and Shimizu, H. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 1998;128(2):209-213. View abstract.
- Naidoo, B. T., Chunterpurshad, I., Mahyoodeen, A. B., and Pather, G. The use of a soy isolate based formula in the treatment of infantile diarrhoea. J Int Med Res. 1981;9(3):232-235. View abstract.
- Nasca, M. M., Zhou, J. R., and Welty, F. K. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol. 7-1-2008;102(1):84-86. View abstract.
- Nestel, P., Cehun, M., Chronopoulos, A., DaSilva, L., Teede, H., and McGrath, B. A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men. Eur.J.Clin.Nutr. 2004;58(3):403-408. View abstract.
- Nies, L. K., Cymbala, A. A., Kasten, S. L., Lamprecht, D. G., and Olson, K. L. Complementary and alternative therapies for the management of dyslipidemia. Ann Pharmacother 2006;40(11):1984-1992. View abstract.
- Noah, M. A. Soy-based formula for infantile diarrhoea: a controlled trial. Niger.Med J 1979;9(2):243-245. View abstract.
- Oggero, R., Garbo, G., Savino, F., and Mostert, M. Dietary modifications versus dicyclomine hydrochloride in the treatment of severe infantile colics. Acta Paediatr. 1994;83(2):222-225. View abstract.
- Onning, G., Akesson, B., Oste, R., and Lundquist, I. Effects of consumption of oat milk, soya milk, or cow's milk on plasma lipids and antioxidative capacity in healthy subjects. Ann.Nutr.Metab 1998;42(4):211-220. View abstract.
- Osborn, D. A. and Sinn, J. Soy formula for prevention of allergy and food intolerance in infants. Cochrane.Database.Syst.Rev 2006;(4):CD003741. View abstract.
- Pendleton, J. M., Tan, W. W., Anai, S., Chang, M., Hou, W., Shiverick, K. T., and Rosser, C. J. Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy. BMC.Cancer 2008;8:132. View abstract.
- Adams, K. F., Lampe, P. D., Newton, K. M., Ylvisaker, J. T., Feld, A., Myerson, D., Emerson, S. S., White, E., Potter, J. D., and Lampe, J. W. Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial. Am J Clin Nutr 2005;82(3):620-626. View abstract.
- Adlercreutz, C. H., Goldin, B. R., Gorbach, S. L., Hockerstedt, K. A., Watanabe, S., Hamalainen, E. K., Markkanen, M. H., Makela, T. H., Wahala, K. T., and Adlercreutz, T. Soybean phytoestrogen intake and cancer risk. J Nutr 1995;125(3 Suppl):757S-770S. View abstract.
- Adlercreutz, H., Honjo, H., Higashi, A., Fotsis, T., Hamalainen, E., Hasegawa, T., and Okada, H. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 1991;54(6):1093-1100. View abstract.
- Allen, J. K., Becker, D. M., Kwiterovich, P. O., Lindenstruth, K. A., and Curtis, C. Effect of soy protein-containing isoflavones on lipoproteins in postmenopausal women. Menopause. 2007;14(1):106-114. View abstract.
- Allen, U. D., McLeod, K., and Wang, E. E. Cow's milk versus soy-based formula in mild and moderate diarrhea: a randomized, controlled trial. Acta Paediatr. 1994;83(2):183-187. View abstract.
- Altorf-van der Kuil, W., Engberink, M. F., Brink, E. J., van Baak, M. A., Bakker, S. J., Navis, G., van, 't, V, and Geleijnse, J. M. Dietary protein and blood pressure: a systematic review. PLoS.One. 2010;5(8):e12102. View abstract.
- Anderson, J. W. and Bush, H. M. Soy protein effects on serum lipoproteins: a quality assessment and meta-analysis of randomized, controlled studies. J.Am.Coll.Nutr. 2011;30(2):79-91. View abstract.
- Anderson, J. W. and Hoie, L. H. Weight loss and lipid changes with low-energy diets: comparator study of milk-based versus soy-based liquid meal replacement interventions. J Am.Coll.Nutr. 2005;24(3):210-216. View abstract.
- Anderson, J. W., Fuller, J., Patterson, K., Blair, R., and Tabor, A. Soy compared to casein meal replacement shakes with energy-restricted diets for obese women: randomized controlled trial. Metabolism 2007;56(2):280-288. View abstract.
- Arjmandi, B. H., Khalil, D. A., Lucas, E. A., Smith, B. J., Sinichi, N., Hodges, S. B., Juma, S., Munson, M. E., Payton, M. E., Tivis, R. D., and Svanborg, A. Soy protein may alleviate osteoarthritis symptoms. Phytomedicine. 2004;11(7-8):567-575. View abstract.
- Ashton, E. and Ball, M. Effects of soy as tofu vs meat on lipoprotein concentrations. Eur.J.Clin.Nutr. 2000;54(1):14-19. View abstract.
- Azadbakht, L., Kimiagar, M., Mehrabi, Y., Esmaillzadeh, A., Padyab, M., Hu, F. B., and Willett, W. C. Soy inclusion in the diet improves features of the metabolic syndrome: a randomized crossover study in postmenopausal women. Am J Clin Nutr 2007;85(3):735-741. View abstract.
- Baer, D. J., Stote, K. S., Paul, D. R., Harris, G. K., Rumpler, W. V., and Clevidence, B. A. Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults. J Nutr 2011;141(8):1489-1494. View abstract.
- Barnes, S., Sfakianos, J., Coward, L., and Kirk, M. Soy isoflavonoids and cancer prevention. Underlying biochemical and pharmacological issues. Adv.Exp.Med Biol. 1996;401:87-100. View abstract.
- Baum, J. A., Teng, H., Erdman, J. W., Jr., Weigel, R. M., Klein, B. P., Persky, V. W., Freels, S., Surya, P., Bakhit, R. M., Ramos, E., Shay, N. F., and Potter, S. M. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am.J.Clin.Nutr. 1998;68(3):545-551. View abstract.
- Berseth, C. L., Johnston, W. H., Stolz, S. I., Harris, C. L., and Mitmesser, S. H. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin.Pediatr.(Phila) 2009;48(1):58-65. View abstract.
- Bertipaglia de Santana, M., Mandarino, M. G., Cardoso, J. R., Dichi, I., Dichi, J. B., Camargo, A. E., Fabris, B. A., Rodrigues, R. J., Fatel, E. C., Nixdorf, S. L., Simao, A. N., Cecchini, R., and Barbosa, D. S. Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects. Nutrition 2008;24(6):562-568. View abstract.
- Blum, A., Lang, N., Peleg, A., Vigder, F., Israeli, P., Gumanovsky, M., Lupovitz, S., Elgazi, A., and Ben Ami, M. Effects of oral soy protein on markers of inflammation in postmenopausal women with mild hypercholesterolemia. Am Heart J 2003;145(2):e7. View abstract.
- Blum, A., Lang, N., Vigder, F., Israeli, P., Gumanovsky, M., Lupovitz, S., Elgazi, A., Peleg, A., and Ben Ami, M. Effects of soy protein on endothelium-dependent vasodilatation and lipid profile in postmenopausal women with mild hypercholesterolemia. Clin Invest Med 2003;26(1):20-26. View abstract.
- Bolanos, R., Del, Castillo A., and Francia, J. Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause. 2010;17(3):660-666. View abstract.
- Bosland MC, Davies JA, and Voermans C. Inhibition of human prostate cancer cell proliferation by genistein [abstract]. Proc Am Assoc Cancer Res 1997;38:262.
- Bricarello, L. P., Kasinski, N., Bertolami, M. C., Faludi, A., Pinto, L. A., Relvas, W. G., Izar, M. C., Ihara, S. S., Tufik, S., and Fonseca, F. A. Comparison between the effects of soy milk and non-fat cow milk on lipid profile and lipid peroxidation in patients with primary hypercholesterolemia. Nutrition 2004;20(2):200-204. View abstract.
- Bryant, M., Cassidy, A., Hill, C., Powell, J., Talbot, D., and Dye, L. Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome. Br.J.Nutr. 2005;93(5):731-739. View abstract.
- Calvo Romero, J. M. and Lima Rodriguez, E. M. ["Natural" treatments of hypercholesterolemia]. Rev Clin Esp. 2006;206(10):504-506. View abstract.
- Campbell, J. P. Dietary treatment of infant colic: a double-blind study. J.R.Coll.Gen.Pract. 1989;39(318):11-14. View abstract.
- Capristo, E., Mingrone, G., Addolorato, G., Greco, A. V., and Gasbarrini, G. Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohn's disease. Eur.J Gastroenterol.Hepatol. 2000;12(1):5-11. View abstract.
- Carmignani, L. O., Pedro, A. O., Costa-Paiva, L. H., and Pinto-Neto, A. M. The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: a randomized controlled trial. Maturitas 2010;67(3):262-269. View abstract.
- Carroll, K. K., Giovannetti, P. M., Huff, M. W., Moase, O., Roberts, D. C., and Wolfe, B. M. Hypocholesterolemic effect of substituting soybean protein for animal protein in the diet of healthy young women. Am J Clin Nutr 1978;31(8):1312-1321. View abstract.
- Cassidy, A. and Hooper, L. Phytoestrogens and cardiovascular disease. J Br Menopause.Soc 2006;12(2):49-56. View abstract.
- Chen, S. T., Chen, J. R., Yang, C. S., Peng, S. J., and Ferng, S. H. Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis. Br J Nutr 2006;95(2):366-371. View abstract.
- Chen, S. T., Ferng, S. H., Yang, C. S., Peng, S. J., Lee, H. R., and Chen, J. R. Variable effects of soy protein on plasma lipids in hyperlipidemic and normolipidemic hemodialysis patients. Am.J Kidney Dis. 2005;46(6):1099-1106. View abstract.
- Chorazy, P. A., Himelhoch, S., Hopwood, N. J., Greger, N. G., and Postellon, D. C. Persistent hypothyroidism in an infant receiving a soy formula: case report and review of the literature. Pediatrics 1995;96(1 Pt 1):148-150. View abstract.
- Clement, Y. N., Onakpoya, I., Hung, S. K., and Ernst, E. Effects of herbal and dietary supplements on cognition in menopause: a systematic review. Maturitas 2011;68(3):256-263. View abstract.
- Cuevas, A. M., Irribarra, V. L., Castillo, O. A., Yanez, M. D., and Germain, A. M. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur.J Clin.Nutr. 2003;57(8):889-894. View abstract.
- D'Amico, G., Gentile, M. G., Manna, G., Fellin, G., Ciceri, R., Cofano, F., Petrini, C., Lavarda, F., Perolini, S., and Porrini, M. Effect of vegetarian soy diet on hyperlipidaemia in nephrotic syndrome. Lancet 5-9-1992;339(8802):1131-1134. View abstract.
- Dagan, R., Gorodischer, R., and Moses, S. W. Dietary treatment of acute diarrhea: comparison between cow's milk and a soy formula without disaccharides. J Trop.Pediatr. 1984;30(4):221-224. View abstract.
- Dalais, F. S., Ebeling, P. R., Kotsopoulos, D., McGrath, B. P., and Teede, H. J. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin Endocrinol.(Oxf) 2003;58(6):704-709. View abstract.
- Darling, A. L., Millward, D. J., Torgerson, D. J., Hewitt, C. E., and Lanham-New, S. A. Dietary protein and bone health: a systematic review and meta-analysis. Am.J.Clin.Nutr. 2009;90(6):1674-1692. View abstract.
- Davidsson, L., Almgren, A., Juillerat, M. A., and Hurrell, R. F. Manganese absorption in humans: the effect of phytic acid and ascorbic acid in soy formula. Am.J.Clin.Nutr. 1995;62(5):984-987. View abstract.
- Davidsson, L., Galan, P., Kastenmayer, P., Cherouvrier, F., Juillerat, M. A., Hercberg, S., and Hurrell, R. F. Iron bioavailability studied in infants: the influence of phytic acid and ascorbic acid in infant formulas based on soy isolate. Pediatr.Res. 1994;36(6):816-822. View abstract.
- Descovich, G. C., Ceredi, C., Gaddi, A., Benassi, M. S., Mannino, G., Colombo, L., Cattin, L., Fontana, G., Senin, U., Mannarino, E., Caruzzo, C., Bertelli, E., Fragiacomo, C., Noseda, G., Sirtori, M., and Sirtori, C. R. Multicentre study of soybean protein diet for outpatient hyper- cholesterolaemic patients. Lancet 10-4-1980;2(8197):709-712. View abstract.
- Dong, J. Y., Tong, X., Wu, Z. W., Xun, P. C., He, K., and Qin, L. Q. Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials. Br.J.Nutr. 2011;106(3):317-326. View abstract.
- Dragan, I., Stroescu, V., Stoian, I., Georgescu, E., and Baloescu, R. Studies regarding the efficiency of Supro isolated soy protein in Olympic athletes. Rev Roum.Physiol 1992;29(3-4):63-70. View abstract.
- Engel, P. A. New onset migraine associated with use of soy isoflavone supplements. Neurology 10-22-2002;59(8):1289-1290. View abstract.
- Engelman, H. M., Alekel, D. L., Hanson, L. N., Kanthasamy, A. G., and Reddy, M. B. Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women. Am.J.Clin.Nutr. 2005;81(3):590-596. View abstract.
- Fioravanti, L., Cappelletti, V., Miodini, P., Ronchi, E., Brivio, M., and Di Fronzo, G. Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett 8-14-1998;130(1-2):143-152. View abstract.
- Fitzpatrick, M. Soy formulas and the effects of isoflavones on the thyroid. N.Z.Med J 2-11-2000;113(1103):24-26. View abstract.
- Frankenfield, D. C. and Beyer, P. L. Soy-polysaccharide fiber: effect on diarrhea in tube-fed, head-injured patients. Am J Clin Nutr 1989;50(3):533-538. View abstract.
- Freni-Titulaer, L. W., Cordero, J. F., Haddock, L., Lebron, G., Martinez, R., and Mills, J. L. Premature thelarche in Puerto Rico. A search for environmental factors. Am.J Dis.Child 1986;140(12):1263-1267. View abstract.
- Fritz, W. A., Wang, J., Eltoum, I. E., and Lamartiniere, C. A. Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol.Cell Endocrinol 1-15-2002;186(1):89-99. View abstract.
- Fujita, H., Yamagami, T., and Ohshima, K. Long-term ingestion of a fermented soybean-derived Touchi-extract with alpha-glucosidase inhibitory activity is safe and effective in humans with borderline and mild type-2 diabetes. J Nutr 2001;131(8):2105-2108. View abstract.
- Fumagalli, R., Soleri, L., Farina, R., Musanti, R., Mantero, O., Noseda, G., Gatti, E., and Sirtori, C. R. Fecal cholesterol excretion studies in type II hypercholesterolemic patients treated with the soybean protein diet. Atherosclerosis 1982;43(2-3):341-353. View abstract.
- Gaddi, A., Ciarrocchi, A., Matteucci, A., Rimondi, S., Ravaglia, G., Descovich, G. C., and Sirtori, C. R. Dietary treatment for familial hypercholesterolemia--differential effects of dietary soy protein according to the apolipoprotein E phenotypes. Am.J Clin.Nutr. 1991;53(5):1191-1196. View abstract.
- Gaddi, A., Descovich, G. C., Noseda, G., Fragiacomo, C., Nicolini, A., Montanari, G., Vanetti, G., Sirtori, M., Gatti, E., and Sirtori, C. R. Hypercholesterolaemia treated by soybean protein diet. Arch.Dis.Child 1987;62(3):274-278. View abstract.
- Gardner, C. D., Messina, M., Kiazand, A., Morris, J. L., and Franke, A. A. Effect of two types of soy milk and dairy milk on plasma lipids in hypercholesterolemic adults: a randomized trial. J Am Coll.Nutr 2007;26(6):669-677. View abstract.
- Garrido, A., De la Maza, M. P., Hirsch, S., and Valladares, L. Soy isoflavones affect platelet thromboxane A2 receptor density but not plasma lipids in menopausal women. Maturitas 6-20-2006;54(3):270-276. View abstract.
- Gentile MG, Manna G, and D'Amico G. Soy consumption and renal function in patients with nephrotic syndrome: clinical effects and potential mechanism. Am J Clin Nutr 1998;68(suppl):1516s.
- Gimenez, I., Martinez, R. M., Lou, M., Mayoral, J. A., Garay, R. P., and Alda, J. O. Salidiuretic action by genistein in the isolated, perfused rat kidney. Hypertension 1998;31(2):706-711. View abstract.
- Giovannetti, P. M. Constancy of fasting serum cholesterol of healthy young women upon substitution of soy protein isolate for meat and dairy protein in medium and low fat diets. Nutr Res 1986;6:609-618.
- Goldberg, A. P., Lim, A., Kolar, J. B., Grundhauser, J. J., Steinke, F. H., and Schonfeld, G. Soybean protein independently lowers plasma cholesterol levels in primary hypercholesterolemia. Atherosclerosis 1982;43(2-3):355-367. View abstract.
- Greany, K. A., Nettleton, J. A., Wangen, K. E., Thomas, W., and Kurzer, M. S. Probiotic consumption does not enhance the cholesterol-lowering effect of soy in postmenopausal women. J Nutr. 2004;134(12):3277-3283. View abstract.
- Hall, W. L., Vafeiadou, K., Hallund, J., Bugel, S., Reimann, M., Koebnick, C., Zunft, H. J., Ferrari, M., Branca, F., Dadd, T., Talbot, D., Powell, J., Minihane, A. M., Cassidy, A., Nilsson, M., Dahlman-Wright, K., Gustafsson, J. A., and Williams, C. M. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2006;83(3):592-600. View abstract.
- Halpin, T. C., Byrne, W. J., and Ament, M. E. Colitis, persistent diarrhea, and soy protein intolerance. J Pediatr. 1977;91(3):404-407. View abstract.
- Hamilton-Reeves, J. M., Rebello, S. A., Thomas, W., Kurzer, M. S., and Slaton, J. W. Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer. Nutr Cancer 2008;60(1):7-13. View abstract.
- Hamilton-Reeves, J. M., Rebello, S. A., Thomas, W., Slaton, J. W., and Kurzer, M. S. Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer. J Nutr 2007;137(7):1769-1775. View abstract.
- Hanson, L. N., Engelman, H. M., Alekel, D. L., Schalinske, K. L., Kohut, M. L., and Reddy, M. B. Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Am J Clin Nutr 2006;84(4):774-780. View abstract.
- Harding C, Morton M, Gould V, and et al. Dietary soy supplementation is estrogenic in menopausal women [abstract]. Proc 2nd Int Symp Role Soy Preventing Treating Chronic Disease. St Louis: Protein Technologies International;1996.
- Hartman, J. W., Tang, J. E., Wilkinson, S. B., Tarnopolsky, M. A., Lawrence, R. L., Fullerton, A. V., and Phillips, S. M. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr 2007;86(2):373-381. View abstract.
- Hermansen, K., Hansen, B., Jacobsen, R., Clausen, P., Dalgaard, M., Dinesen, B., Holst, J. J., Pedersen, E., and Astrup, A. Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects. Eur.J Clin.Nutr. 2005;59(7):843-850. View abstract.
- Hermansen, K., Sondergaard, M., Hoie, L., Carstensen, M., and Brock, B. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care 2001;24(2):228-233. View abstract.
- Higashi, K., Abata, S., Iwamoto, N., Ogura, M., Yamashita, T., Ishikawa, O., Ohslzu, F., and Nakamura, H. Effects of soy protein on levels of remnant-like particles cholesterol and vitamin E in healthy men. J Nutr Sci.Vitaminol.(Tokyo) 2001;47(4):283-288. View abstract.
- Hill, D. J., Heine, R. G., Cameron, D. J., Francis, D. E., and Bines, J. E. The natural history of intolerance to soy and extensively hydrolyzed formula in infants with multiple food protein intolerance. J.Pediatr. 1999;135(1):118-121. View abstract.
- Hilpert, K. F., Kris-Etherton, P. M., and West, S. G. Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults. J Nutr. 2005;135(5):1075-1079. View abstract.
- Hoie, L. H., Graubaum, H. J., Harde, A., Gruenwald, J., and Wernecke, K. D. Lipid-lowering effect of 2 dosages of a soy protein supplement in hypercholesterolemia. Adv.Ther 2005;22(2):175-186. View abstract.
- Hoie, L. H., Guldstrand, M., Sjoholm, A., Graubaum, H. J., Gruenwald, J., Zunft, H. J., and Lueder, W. Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. Adv Ther 2007;24(2):439-447. View abstract.
- Hoie, L. H., Morgenstern, E. C., Gruenwald, J., Graubaum, H. J., Busch, R., Luder, W., and Zunft, H. J. A double-blind placebo-controlled clinical trial compares the cholesterol-lowering effects of two different soy protein preparations in hypercholesterolemic subjects. Eur.J.Nutr. 2005;44(2):65-71. View abstract.
- Holmes WL, Rubel GB, and Hood SE. Comparison of the effect of dietary meat versus dietary soybean protein on plasma lipids of hyperlipidemic individuals. Atherosclerosis 1980;36:379-387.
- Holst-Jensen, S. E., Pfeiffer-Jensen, M., Monsrud, M., Tarp, U., Buus, A., Hessov, I., Thorling, E., and Stengaard-Pedersen, K. Treatment of rheumatoid arthritis with a peptide diet: a randomized, controlled trial. Scand.J.Rheumatol. 1998;27(5):329-336. View abstract.
- Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., and Cassidy, A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88(1):38-50. View abstract.
- Hori, G., Wang, M. F., Chan, Y. C., Komatsu, T., Wong, Y., Chen, T. H., Yamamoto, K., Nagaoka, S., and Yamamoto, S. Soy protein hydrolyzate with bound phospholipids reduces serum cholesterol levels in hypercholesterolemic adult male volunteers. Biosci.Biotechnol.Biochem 2001;65(1):72-78. View abstract.
- Huff, M. W., Giovannetti, P. M., and Wolfe, B. M. Turnover of very low-density lipoprotein-apoprotein B is increased by substitution of soybean protein for meat and dairy protein in the diets of hypercholesterolemic men. Am J Clin Nutr 1984;39(6):888-897. View abstract.
- Iyngkaran, N., Yadav, M., Looi, L. M., Boey, C. G., Lam, K. L., Balabaskaran, S., and Puthucheary, S. D. Effect of soy protein on the small bowel mucosa of young infants recovering from acute gastroenteritis. J Pediatr.Gastroenterol.Nutr 1988;7(1):68-75. View abstract.
- Izumi, T., Saito, M., Obata, A., Arii, M., Yamaguchi, H., and Matsuyama, A. Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J Nutr Sci Vitaminol.(Tokyo) 2007;53(1):57-62. View abstract.
- Jacques, H., Laurin, D., Moorjani, S., Steinke, F. H., Gagne, C., Brun, D., and Lupien, P. J. Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia. J.Am.Coll.Nutr. 1992;11 Suppl:69S-73S. View abstract.
- Jenkins, D. J., Kendall, C. W., Vidgen, E., Vuksan, V., Jackson, C. J., Augustin, L. S., Lee, B., Garsetti, M., Agarwal, S., Rao, A. V., Cagampang, G. B., and Fulgoni, V., III. Effect of soy-based breakfast cereal on blood lipids and oxidized low- density lipoprotein. Metabolism 2000;49(11):1496-1500. View abstract.
- Jenkins, D. J., Wolever, T. M., Spiller, G., Buckley, G., Lam, Y., Jenkins, A. L., and Josse, R. G. Hypocholesterolemic effect of vegetable protein in a hypocaloric diet. Atherosclerosis 1989;78(2-3):99-107. View abstract.
- Kalhan, R., Smith, L. J., Nlend, M. C., Nair, A., Hixon, J. L., and Sporn, P. H. A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis. Clin Exp Allergy 2008;38(1):103-112. View abstract.
- Kim, H., Xu, J., Su, Y., Xia, H., Li, L., Peterson, G., Murphy-Ullrich, J., and Barnes, S. Actions of the soy phytoestrogen genistein in models of human chronic disease: potential involvement of transforming growth factor beta. Biochem Soc Trans. 2001;29(Pt 2):216-222. View abstract.
- Kobayashi, M., Nagatani, Y., Magishi, N., Tokuriki, N., Nakata, Y., Tsukiyama, R., Imai, H., Suzuki, M., Saito, M., and Tsuji, K. Promotive effect of Shoyu polysaccharides from soy sauce on iron absorption in animals and humans. Int J Mol.Med 2006;18(6):1159-1163. View abstract.
- Kohno, M., Hirotsuka, M., Kito, M., and Matsuzawa, Y. Decreases in serum triacylglycerol and visceral fat mediated by dietary soybean beta-conglycinin. J Atheroscler.Thromb. 2006;13(5):247-255. View abstract.
- Kok, L., Kreijkamp-Kaspers, S., Grobbee, D. E., Lampe, J. W., and van der Schouw, Y. T. Soy isoflavones, body composition, and physical performance. Maturitas 10-16-2005;52(2):102-110. View abstract.
- Konig, D., Deibert, P., Frey, I., Landmann, U., and Berg, A. Effect of meal replacement on metabolic risk factors in overweight and obese subjects. Ann Nutr Metab 2008;52(1):74-78. View abstract.
- Kumar, N. B., Cantor, A., Allen, K., Riccardi, D., and Cox, C. E. The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer 2-15-2002;94(4):1166-1174. View abstract.
- Kurowska, E. M., Jordan, J., Spence, J. D., Wetmore, S., Piche, L. A., Radzikowski, M., Dandona, P., and Carroll, K. K. Effects of substituting dietary soybean protein and oil for milk protein and fat in subjects with hypercholesterolemia. Clin.Invest Med. 1997;20(3):162-170. View abstract.
- Lampe, J. W., Karr, S. C., Hutchins, A. M., and Slavin, J. L. Urinary equol excretion with a soy challenge: influence of habitual diet. Proc Soc.Exp.Biol.Med 1998;217(3):335-339. View abstract.
- Laurin, D., Jacques, H., Moorjani, S., Steinke, F. H., Gagne, C., Brun, D., and Lupien, P. J. Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia. Am.J.Clin.Nutr. 1991;54(1):98-103. View abstract.
- Li, Z., Hong, K., Saltsman, P., DeShields, S., Bellman, M., Thames, G., Liu, Y., Wang, H. J., Elashoff, R., and Heber, D. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur.J Clin.Nutr. 2005;59(3):411-418. View abstract.
- Liao, F. H., Shieh, M. J., Yang, S. C., Lin, S. H., and Chien, Y. W. Effectiveness of a soy-based compared with a traditional low-calorie diet on weight loss and lipid levels in overweight adults. Nutrition 2007;23(7-8):551-556. View abstract.
- Librenti, M. C., Cocchi, M., Orsi, E., Pozza, G., and Micossi, P. Effect of soya and cellulose fibers on postprandial glycemic response in type II diabetic patients. Diabetes Care 1992;15(1):111-113. View abstract.
- Lichtenstein, A. H., Jalbert, S. M., Adlercreutz, H., Goldin, B. R., Rasmussen, H., Schaefer, E. J., and Ausman, L. M. Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler.Thromb.Vasc.Biol. 11-1-2002;22(11):1852-1858. View abstract.
- Liu, J., Ho, S. C., Su, Y. X., Chen, W. Q., Zhang, C. X., and Chen, Y. M. Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone 2009;44(5):948-953. View abstract.
- Liu, Z. M., Chen, Y. M., and Ho, S. C. Effects of soy intake on glycemic control: a meta-analysis of randomized controlled trials. Am.J.Clin.Nutr. 2011;93(5):1092-1101. View abstract.
- Lo GS and Cole TG. Soy cotyledon fiber products reduce plasma lipids. Atherosclerosis 1990;82:59-67.
- Lo GS, Goldberg AP, Lim A, and et al. Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects. Atherosclerosis 1986;62:239-248.
- Lothe, L., Lindberg, T., and Jakobsson, I. Cow's milk formula as a cause of infantile colic: a double-blind study. Pediatrics 1982;70(1):7-10. View abstract.
- Post-Skagegard, M., Vessby, B., and Karlstrom, B. Glucose and insulin responses in healthy women after intake of composite meals containing cod-, milk-, and soy protein. Eur J Clin Nutr 2006;60(8):949-954. View abstract.
- Potter, S. M., Bakhit, R. M., Essex-Sorlie, D. L., Weingartner, K. E., Chapman, K. M., Nelson, R. A., Prabhudesai, M., Savage, W. D., Nelson, A. I., Winter, L. W., and . Depression of plasma cholesterol in men by consumption of baked products containing soy protein. Am J Clin Nutr 1993;58(4):501-506. View abstract.
- Puska, P., Korpelainen, V., Hoie, L. H., Skovlund, E., and Smerud, K. T. Isolated soya protein with standardised levels of isoflavones, cotyledon soya fibres and soya phospholipids improves plasma lipids in hypercholesterolaemia: a double-blind, placebo-controlled trial of a yoghurt formulation. Br.J.Nutr. 2004;91(3):393-401. View abstract.
- Qin, L. Q., Xu, J. Y., Wang, P. Y., and Hoshi, K. Soyfood intake in the prevention of breast cancer risk in women: a meta-analysis of observational epidemiological studies. J Nutr Sci Vitaminol.(Tokyo) 2006;52(6):428-436. View abstract.
- Rajah, R., Pettifor, J. M., Noormohamed, M., Venter, A., Rosen, E. U., Rabinowitz, L., and Stein, H. The effect of feeding four different formulae on stool weights in prolonged dehydrating infantile gastroenteritis. J Pediatr.Gastroenterol.Nutr. 1988;7(2):203-207. View abstract.
- Reynolds, K., Chin, A., Lees, K. A., Nguyen, A., Bujnowski, D., and He, J. A meta-analysis of the effect of soy protein supplementation on serum lipids. Am J Cardiol. 9-1-2006;98(5):633-640. View abstract.
- Rossi, E. A., Vendramini, R. C., Carlos, I. Z., de Oliveira, M. G., and de Valdez, G. F. [Effect of a new fermented soy milk product on serum lipid levels in normocholesterolemic adult men]. Arch Latinoam.Nutr. 2003;53(1):47-51. View abstract.
- Rozman, K. K., Bhatia, J., Calafat, A. M., Chambers, C., Culty, M., Etzel, R. A., Flaws, J. A., Hansen, D. K., Hoyer, P. B., Jeffery, E. H., Kesner, J. S., Marty, S., Thomas, J. A., and Umbach, D. NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula. Birth Defects Res B Dev Reprod.Toxicol 2006;77(4):280-397. View abstract.
- Sacks, F. M., Breslow, J. L., Wood, P. G., and Kass, E. H. Lack of an effect of dairy protein (casein) and soy protein on plasma cholesterol of strict vegetarians. An experiment and a critical review. J Lipid Res 1983;24(8):1012-1020. View abstract.
- Sagara, M., Kanda, T., NJelekera, M., Teramoto, T., Armitage, L., Birt, N., Birt, C., and Yamori, Y. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland. J Am.Coll.Nutr. 2004;23(1):85-91. View abstract.
- Santo, A. S., Cunningham, A. M., Alhassan, S., Browne, R. W., Burton, H., Leddy, J. J., Grandjean, P. W., Horvath, S. M., and Horvath, P. J. NMR analysis of lipoprotein particle size does not increase sensitivity to the effect of soy protein on CVD risk when compared with the traditional lipid profile. Appl.Physiol Nutr Metab 2008;33(3):489-500. View abstract.
- Santosham, M., Foster, S., Reid, R., Bertrando, R., Yolken, R., Burns, B., and Sack, R. B. Role of soy-based, lactose-free formula during treatment of acute diarrhea. Pediatrics 1985;76(2):292-298. View abstract.
- Santosham, M., Goepp, J., Burns, B., Reid, R., O'Donovan, C., Pathak, R., and Sack, R. B. Role of a soy-based lactose-free formula in the outpatient management of diarrhea. Pediatrics 1991;87(5):619-622. View abstract.
- Sheikh, C. and Erickson, P. R. Evaluation of plaque pH changes following oral rinse with eight infant formulas. Pediatr.Dent. 1996;18(3):200-204. View abstract.
- Shorey, R. L., Bazan, B., Lo, G. S., and Steinke, F. H. Determinants of hypocholesterolemic response to soy and animal protein- based diets. Am J Clin Nutr 1981;34(9):1769-1778. View abstract.
- Sirtori CR, Manzoni C, Gianazza E, and et al. Soy and cholesterol reduction: clinical experience and molecular mechanisms. Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease 1996;
- Sirtori, C. R., Agradi, E., Conti, F., Mantero, O., and Gatti, E. Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia. Lancet 2-5-1977;1(8006):275-277. View abstract.
- Sirtori, C. R., Bosisio, R., Pazzucconi, F., Bondioli, A., Gatti, E., Lovati, M. R., and Murphy, P. Soy milk with a high glycitein content does not reduce low-density lipoprotein cholesterolemia in type II hypercholesterolemic patients. Ann Nutr Metab 2002;46(2):88-92. View abstract.
- Sirtori, C. R., Gianazza, E., Manzoni, C., Lovati, M. R., and Murphy, P. A. Role of isoflavones in the cholesterol reduction by soy proteins in the clinic. Am J Clin Nutr 1997;65(1):166-167. View abstract.
- Slavin, J. L., Karr, S. C., Hutchins, A. M., and Lampe, J. W. Influence of soybean processing, habitual diet, and soy dose on urinary isoflavonoid excretion. Am.J.Clin.Nutr. 1998;68(6 Suppl):1492S-1495S. View abstract.
- St Onge, M. P., Claps, N., Wolper, C., and Heymsfield, S. B. Supplementation with soy-protein-rich foods does not enhance weight loss. J Am Diet.Assoc 2007;107(3):500-505. View abstract.
- Steele, M. G. The effect on serum cholesterol levels of substituting milk with a soya beverage. Aust J Nutr Diet 1992;49:24-28.
- Steinberg, F. M., Guthrie, N. L., Villablanca, A. C., Kumar, K., and Murray, M. J. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr. 2003;78(1):123-130. View abstract.
- Swami, S., Krishnan, A. V., Moreno, J., Bhattacharyya, R. S., Gardner, C., Brooks, J. D., Peehl, D. M., and Feldman, D. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. Int J Cancer 5-1-2009;124(9):2050-2059. View abstract.
- Thomas, B. L., Laine, D. C., and Goetz, F. C. Glucose and insulin response in diabetic subjects: acute effect of carbohydrate level and the addition of soy polysaccharide in defined-formula diets. Am.J Clin.Nutr. 1988;48(4):1048-1052. View abstract.
- Torres, N., Torre-Villalvazo, I., and Tovar, A. R. Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J Nutr Biochem 2006;17(6):365-373. View abstract.
- van Raaij, J. M., Katan, M. B., Hautvast, J. G., and Hermus, R. J. Effects of casein versus soy protein diets on serum cholesterol and lipoproteins in young healthy volunteers. Am J Clin Nutr 1981;34(7):1261-1271. View abstract.
- van Raaij, J. M., Katan, M. B., West, C. E., and Hautvast, J. G. Influence of diets containing casein, soy isolate, and soy concentrate on serum cholesterol and lipoproteins in middle-aged volunteers. Am J Clin Nutr 1982;35(5):925-934. View abstract.
- Van Wyk JJ, Arnold MB, Wynn J, and et al. The effects of a soybean product on thyroid function in humans. Pediatrics 1959;24:752-760.
- Verrillo, A., de Teresa, A., Carandente, Giarrusso P., and La Rocca, S. Soybean protein diets in the management of type II hyperlipoproteinaemia. Atherosclerosis 1985;54(3):321-331. View abstract.
- Vessby, B., Karlstrom, B., Lithell, H., Gustafsson, I. B., and Werner, I. The effects on lipid and carbohydrate metabolism of replacing some animal protein by soy-protein in a lipid-lowering diet for hypercholesterolaemic patients. Hum.Nutr Appl Nutr 1982;36(3):179-189. View abstract.
- Vigna, G. B., Pansini, F., Bonaccorsi, G., Albertazzi, P., Donega, P., Zanotti, L., De Aloysio, D., Mollica, G., and Fellin, R. Plasma lipoproteins in soy-treated postmenopausal women: a double-blind, placebo-controlled trial. Nutr.Metab Cardiovasc.Dis. 2000;10(6):315-322. View abstract.
- Wahner-Roedler, D. L., Thompson, J. M., Luedtke, C. A., King, S. M., Cha, S. S., Elkin, P. L., Bruce, B. K., Townsend, C. O., Bergeson, J. R., Eickhoff, A. L., Loehrer, L. L., Sood, A., and Bauer, B. A. Dietary soy supplement on fibromyalgia symptoms: a randomized, double-blind, placebo-controlled, early phase trial. Evid.Based.Complement Alternat.Med. 2011;2011:350697. View abstract.
- Wallo, W., Nebus, J., and Leyden, J. J. Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study. J Drugs Dermatol 2007;6(9):917-922. View abstract.
- Wang, Y., Jones, P. J., Ausman, L. M., and Lichtenstein, A. H. Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects. Atherosclerosis 2004;173(2):269-275. View abstract.
- Weickert, M. O., Reimann, M., Otto, B., Hall, W. L., Vafeiadou, K., Hallund, J., Ferrari, M., Talbot, D., Branca, F., Bugel, S., Williams, C. M., Zunft, H. J., and Koebnick, C. Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women. J Negat.Results Biomed 2006;5:11. View abstract.
- Welty, F. K., Lee, K. S., Lew, N. S., and Zhou, J. R. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med 5-28-2007;167(10):1060-1067. View abstract.
- West, S. G., Hilpert, K. F., Juturu, V., Bordi, P. L., Lampe, J. W., Mousa, S. A., and Kris-Etherton, P. M. Effects of including soy protein in a blood cholesterol-lowering diet on markers of cardiac risk in men and in postmenopausal women with and without hormone replacement therapy. J Womens Health (Larchmt.) 2005;14(3):253-262. View abstract.
- Whelan, A. M., Jurgens, T. M., and Naylor, H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Can.J.Clin.Pharmacol. 2009;16(3):e407-e429. View abstract.
- Widhalm, K. Effect of diet on serum lipids and lipoprotein in hyperlipoproteinemic children. In: Beynen, A. C. Nutritional effects on cholesterol metabolism. Voorthuizen, the Netherlands: Transmondial;1986.
- Widhalm, K., Brazda, G., Schneider, B., and Kohl, S. Effect of soy protein diet versus standard low fat, low cholesterol diet on lipid and lipoprotein levels in children with familial or polygenic hypercholesterolemia. J.Pediatr. 1993;123(1):30-34. View abstract.
- Wolfe, B. M., Giovannetti, P. M., Cheng, D. C. H., Roberts, D. C. K., and Carroll, K. K. Hypolipidemic effect of substituting soybean protein isolate for all meat and dairy protein in the diets of hypercholesterolemic men. Nutr Rep Int 1981;24:1187-1198.
- Wong WW, Hachey DL, Smith EO, and et al. Mechanisms for the hypocholeste-rolemic effect of soy protein in normocholesterolemic and hypercholesterolemic men. Second International Symposium on the Role of Soy in Preventing and Treating Chronic Disease 1996;
- Wu, A. H., Ziegler, R. G., Horn-Ross, P. L., Nomura, A. M., West, D. W., Kolonel, L. N., Rosenthal, J. F., Hoover, R. N., and Pike, M. C. Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):901-906. View abstract.
- Xu, X., Harris, K. S., Wang, H. J., Murphy, P. A., and Hendrich, S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995;125(9):2307-2315. View abstract.
- Xu, X., Wang, H. J., Murphy, P. A., Cook, L., and Hendrich, S. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J.Nutr. 1994;124(6):825-832. View abstract.
- Yamashita, T., Sasahara, T., Pomeroy, S. E., Collier, G., and Nestel, P. J. Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet. Metabolism 1998;47(11):1308-1314. View abstract.
- Yang, B., Chen, Y., Xu, T., Yu, Y., Huang, T., Hu, X., and Li, D. Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus. Asia Pac.J.Clin.Nutr. 2011;20(4):593-602. View abstract.
- Zhan, S. and Ho, S. C. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am.J Clin.Nutr. 2005;81(2):397-408. View abstract.
- Zhuo, X. G., Melby, M. K., and Watanabe, S. Soy isoflavone intake lowers serum LDL cholesterol: a meta-analysis of 8 randomized controlled trials in humans. J Nutr. 2004;134(9):2395-2400. View abstract.
- Adams KF, Chen C, Newton KM, et al. Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2004;13:644-8. View abstract.
- Adlercreutz H, Mazur W, Bartels P, et al. Phytoestrogens and prostate disease. J Nutr 2000;130:658S-9S.
- Al-Wahsh IA, Horner HT, Palmer RG, et al. Oxalate and phytate of soy foods. J Agric Food Chem 2005;53:5670-4.. View abstract.
- Albert A, Altabre C, Baro F, et al. Efficacy and safety of a phytoestrogen preparation derived from Glycine max (L.) Merr in climacteric symptomatology: a multicentric, open, prospective and non-randomized trial. Phytomedicine 2002;9:85-92. View abstract.
- Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998;91:6-11. View abstract.
- Albertazzi P, Pansini F, Bottazzi M, et al. Dietary soy supplementation and phytoestrogen levels. Obstet Gynecol 1999;94:229-31. View abstract.
- Alekel DL, St. Germain A, Peterson CT, et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-52. View abstract.
- Anderson JJ, Chen X, Boass A, et al. Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J Am Coll Nutr 2002;21:388-93.. View abstract.
- Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;333:276-82. View abstract.
- Anon. The role of isoflavones in menopausal health: consensus opinion of the North American Menopause Society. Menopause 2000;7:215-29.. View abstract.
- Anthony MS. Soy and cardiovascular disease: Cholesterol lowering and beyond. J Nutr 2000;130:662S-3S. View abstract.
- Anto JM, Sunyer J, Rodriguez-Roisin R, et al. Community outbreaks of asthma associated with inhalation of soybean dust. Toxicoepidemiological Committee. N Engl J Med 1989;320:1097-1102. View abstract.
- Arai Y, Watanabe S, Kimira M, et al. Dietary intake of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 2000;130:2243-50. View abstract.
- Arjmandi BH, Khalil DA, Smith BJ, et al. Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion. J Clin Endocrinol Metab 2003;88:1048-54.. View abstract.
- Ashton EL, Dalais FS, Ball MJ. Effect of meat replacement by tofu on CHD risk factors including copper induced LDL oxidation. J Am Coll Nutr 2000;19:761-7. View abstract.
- Azadbakht L, Shakerhosseini R, Atabak S, et al. Beneficiary effect of dietary soy protein on lowering plasma levels of lipid and improving kidney function in type II diabetes with nephropathy. Eur J Clin Nutr 2003;57:1292-4. View abstract.
- Baird DD, Umbach DM, Lansdell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995;80:1685-90. View abstract.
- Bakhit RM, Klein BP, Essex-Sorlie D, et al. Intake of 25 g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. J Nutr 1994;124:213-22. View abstract.
- Balk E, Chung M, Chew P, et al. Effects of soy on health outcomes. Summary, Evidence Report/Technology Assessment: Number 126. AHRQ Publication Number 05-E024-1, August 2005. Agency for Healthcare Research and Quality, Rockville, MD. Available at: http://www.ahrq.gov/clinic/epcsums/soysum.htm (Accessed 4 February 2006).
- Balk JL, Whiteside DA, Naus G, et al. A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium. J Soc Gynecol Investig 2002;9:238-42.. View abstract.
- Barnes S, Kim H, Darley-Usmar V, et al. Beyond ERalpha and ERbeta: Estrogen receptor binding is only part of the isoflavone story. J Nutr 2000;130:656S-7S. View abstract.
- Barnes S. Phytoestrogens and breast cancer. Baillieres Clin Endocrinol Metab 1998;12:559-79. View abstract.
- Barni S, Mori F, Pantano S, Novembre E. Adverse reaction to benzathine benzylpenicillin due to soy allergy: a case report. J Med Case Rep. 2015;9:134. View abstract.
- Bektic J, Berger AP, Pfeil K, et al. Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta. Eur Urol 2004;45:245-51. View abstract.
- Berger PK, Principe JL, Laing EM, et al. Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. Nutr Res. 2014;34(1):66-73. View abstract.
- Bosland MC, Kato I, Zeleniuch-Jacquotte A, et al. Effect of soy protein isolate supplementation on biochemical recurrence of prostate cancer after radical prostatectomy: a randomized trial. JAMA. 2013;310(2):170-8. View abstract.
- Brown BD, Thomas W, Hutchins A, et al. Types of dietary fat and soy minimally affect hormones and biomarkers associated with breast cancer risk in premenopausal women. Nutr Cancer 2002;43:22-30.. View abstract.
- Brown KH, Perez F, Peerson JM, et al. Effect of dietary fiber (soy polysaccharide) on the severity, duration, and nutritional outcome of acute, watery diarrhea in children. Pediatrics 1993;92:241-7. View abstract.
- Bruce B, Messina M, Spiller G. Isoflavone supplements do not affect thyroid function in iodine-replete postmemopausal women. J Med Food 2003;6:309-16. View abstract.
- Brzezinski A, Adlercreutz H, Sheoul R, et al. Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 1997;4:89-94.
- Budhathoki S, Iwasaki M, Sawada N, et al.; JPHC Study Group. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG. 2015;122(3):304-11. View abstract.
- Burke BE, Olson RD, Cusack BJ. Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine. Biomed Pharmacother 2002;56:283-8. View abstract.
- Burke GL, Legault C, Anthony M, et al. Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study. Menopause 2003;10:147-53.. View abstract.
- Burke V, Hodgson JM, Beilin LJ, et al. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension 2001;38:821-6.. View abstract.
- Busby MG, Jeffcoat AR, Bloedon LT, et al. Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr 2002;75:126-36. View abstract.
- Cambria-Kiely JA. Effect of soy milk on warfarin efficacy. Ann Pharmacother 2002;36:1893-6.. View abstract.
- Candow DG, Burke NC, Smith-Palmer T, Burke DG. Effect of whey and soy protein supplementation combined with resistance training in young adults. Int J Sport Nutr Exerc Metab 2006;16:233-44. View abstract.
- Chan GM, Leeper L, Book LS. Effects of soy formulas on mineral metabolism in term infants. Am J Dis Child. 1987;141(5):527-30. View abstract.
- Chen A, Rogan WJ. Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annu Rev Nutr 2004;24:33-54. View abstract.
- Chen C, Wang X, Chen D, et al. Tofu consumption and blood lead levels in young Chinese adults. Am J Epidemiol 2001;153:1206-12. View abstract.
- Chen M, Rao Y, Zheng Y, et al. Association between soy isoflavone intake and breast cancer risk for pre- and post-menopausal women: a meta-analysis of epidemiological studies. PLoS One. 2014;9(2):e89288. View abstract.
- Chen YM, Ho SC, Lam SS, et al. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J Clin Endocrinol Metab 2003;88:4740-7. View abstract.
- Chen YM, Ho SC, Lam SS, et al. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause 2004;11246-54. View abstract.
- Chi F, Wu R, Zeng YC, et al. Post-diagnosis soy food intake and breast cancer survival: a meta-analysis of cohort studies. Asian Pac J Cancer Prev. 2013;14(4):2407-12. View abstract.
- Chua R, Anderson K, Chen J, Hu M. Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products. J Altern Complement Med 2004;10:1053-60. View abstract.
- Clarkson TB, Anthony MS, Morgan TM. Inhibition of postmenopausal atherosclerosis progression: a comparison of the effects of conjugated equine estrogens and soy phytoestrogens. J Clin Endocrinol Metab 2001;86:41-7. View abstract.
- Codina R, Ardusso L, Lockey RF, et al. Sensitization to soybean hull allergens in subjects exposed to different levels of soybean dust inhalation in Argentina. J Allergy Clin Immunol 2000;105:570-6. View abstract.
- Committee on Nutrition, American Academy of Pediatrics. Soy protein-based formulas: recommendations for use in infant feeding. Pediatrics 1998;101:148-53.
- Conrad SC, Chiu H, Silverman BL. Soy formula complicates management of congenital hypothyroidism. Arch Dis Child. 2004;89(1):37-40. View abstract.
- Costa RL, Summa MA. Soy protein in the management of hyperlipidemia. Ann Pharmacother 2000;34:931-5. View abstract.
- Crawford SL, Jackson EA, Churchill L, et al. Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes: a pilot randomized trial. Menopause. 2013;20(9):936-45. View abstract.
- Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study. Menopause 2004;11:400-4. View abstract.
- Crouse JR III, Morgan T, Terry JG, et al. A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 1999;159:2070-6. View abstract.
- D'Amico G, Gentile MG. Effect of dietary manipulation on the lipid abnormalities and urinary protein loss in nephrotic patients. Miner Electrolyte Metab 1992;18:203-6. View abstract.
- Dalais FS, Meliala A, Wattanapenpaiboon N, et al. Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology 2004;64:510-5. View abstract.
- de Lemos ML. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother 2001;35:1118-21. View abstract.
- Deibert P, Konig D, Schmidt-Trucksaess A, et al. Weight loss without losing muscle mass in pre-obese and obese subjects induced by a high-soy-protein diet. Int J Obes Relat Metab Disord 2004;28:1349-52. View abstract.
- Dent SB, Peterson CT, Brace LD, et al. Soy protein intake by perimenopausal women does not affect circulating lipids and lipoproteins or coagulation and fibrinolytic factors. J Nutr 2001;131:2280-7. View abstract.
- Deplancke B, Gaskins HR. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr 2001;73:1131S-41S. View abstract.
- Dillingham BL, McVeigh BL, Lampe JW, et al. Soy protein isolates of varying isoflavone content exert minor effects on serum reproductive hormones in healthy young men. J Nutr 2005;135:584-91. View abstract.
- Divi RL, Chang HC, Doerge DR. Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Biochem Pharmacol 1997;54:1087-96. View abstract.
- dos Santos Silva I, Mangtani P, McCormack V, et al. Phyto-oestrogen intake and breast cancer risk in South Asian women in England: findings from a population-based case-control study. Cancer Causes Control 2004;15:805-18. View abstract.
- Duffy R, Wiseman H, File SE. Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacol Biochem Behav 2003;75:721-9. View abstract.
- Duncan AM, Merz BE, Xu X, et al. Soy isoflavones exert modest hormonal effects in premenopausal women. J Clin Endocrinol Metab 1999;84:192-7. View abstract.
- Duncan AM, Underhill KE, Xu X, et al. Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999;84:3479-84. View abstract.
- EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA J. 2015;13(10):4246.
- Egert S, Tereszczuk J, Wein S, et al. Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr. 2013 Feb;52(1):281-8. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Engel PA. New onset migraine associated with use of soy isoflavone supplements. Neurology 2002;59:1289-90.
- Erdman JW. AHA Science Advisory: Soy protein and cardiovascular disease. A statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation 2000;102:2555-9. View abstract.
- Estrella RE, Landa AI, Lafuente JV, Gargiulo PA. Effects of antidepressants and soybean association in depressive menopausal women. Acta Pol Pharm. 2014;71(2):323-7. View abstract.
- Evans AM. Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Ther Drug Monit 2000;22:131-6. View abstract.
- Evans BA, Griffiths K, Morton MS. Inhibition of 5 alpha-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and isoflavonoids. J Endocrinol 1995;147:295-302. View abstract.
- Evans M, Njike VY, Hoxley M, et al. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause 2007;14:141-9. View abstract.
- Fang K, Dong H, Wang D, Gong J, Huang W, Lu F. Soy isoflavones and glucose metabolism in menopausal women: A systematic review and meta-analysis of randomized controlled trials. Mol Nutr Food Res. 2016;60(7):1602-14. View abstract.
- Fang N, Yu S, Badger TM. Comprehensive phytochemical profile of soy protein isolate. J Agric Food Chem 2004;52:4012-20. View abstract.
- File SE, Jarrett N, Fluck E, et al. Eating soya improves human memory. Psychopharmacology (Berl) 2001;157:430-6.. View abstract.
- Foth D, Cline JM. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques. Am J Clin Nutr 1998;68:1413S-7S. View abstract.
- Foth D, Nawroth F. Effect of soy supplementation on endogenous hormones in postmenopausal women. Gynecol Obstet Invest 2003;55:135-8. View abstract.
- Franco OH, Chowdhury R, Troup J, et al. Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis. JAMA. 2016 Jun 21;315(23):2554-63. View abstract.
- Franke AA, Custer LJ, Tanaka Y. Isoflavones in human breast milk and other biological fluids. Am J Clin Nutr 1998;68:1466-73. View abstract.
- Fruzza AG, Demeterco-Berggren C, Jones KL. Unawareness of the effects of soy intake on the management of congenital hypothyroidism. Pediatrics. 2012;130(3):e699-702. View abstract.
- Gallagher JC, Satpathy R, Rafferty K, Haynatzka V. The effect of soy protein isolate on bone metabolism. Menopause 2004;11:290-8. View abstract.
- Gardner CD, Chatterjee LM, Carlson JJ. The effect of a garlic preparation on plasma lipid levels in moderately hypercholesterolemic adults. Atherosclerosis 2001;154:213-20. View abstract.
- Gardner CD, Newell KA, Cherin R, Haskell WL. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:728-35. View abstract.
- Gardner DM, Shulman KI, Walker SE, Tailor SA. The making of a user friendly MAOI diet. J Clin Psychiatry 1996;57:99-104. View abstract.
- Gardner-Thorpe D, O'Hagen C, Young I, Lewis SJ. Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men. Eur J Clin Nutr 2003;57:100-6.. View abstract.
- Geller J, Sionit L, Partido C, et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998;34:75-9. View abstract.
- Gentile MG, Fellin G, Cofano F, et al. Treatment of proteinuric patients with a vegetarian soy diet and fish oil. Clin Nephrol 1993;40:315-20. View abstract.
- Ginsburg J, Prelevic GM. Lack of significant hormonal effects and controlled trials of phyto-oestrogens. Lancet 2000;355:163-4. View abstract.
- Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med 2001;161:1161-72. View abstract.
- Gleason CE, Fischer BL, Dowling NM, et al. Cognitive effects of soy isoflavones in patients with Alzheimer's disease. J Alzheimers Dis. 2015;47(4):1009-19. View abstract.
- Goodman MT, Wilkens LR, Hankin JH, et al. Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiol 1997;146:294-306. View abstract.
- Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 2001;131:1202-6. View abstract.
- Graham PH, Vance CP. Legumes: importance and constraints to greater use. Plant Physiol. 2003;131(3):872-7. View abstract.
- Grodstein F, Mayeux R, Stampfer MJ. Tofu and cognitive function: food for thought. J Am Coll Nutr 2000;19:207-9.
- Hakkak R, Korourian S, Shelnutt SR, et al. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev 2000;9:113-7. View abstract.
- Han KK, Soares JM Jr, Haidar MA, et al. Benefits of soy isoflavone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002;99:389-94. View abstract.
- Hargreaves DF, Potten CS, Harding C, et al. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metab 1999;84:4017-24. View abstract.
- Haselkorn T, Stewart SL, Horn-Ross PL. Why are thyroid cancer rates so high in southeast Asian women living in the United States? The Bay Area Thyroid Cancer Study. Cancer Epidemiol Biomarkers Prev 2003;12:144-50. View abstract.
- He J, Gu D, Wu X, et al. Effect of soybean protein on blood pressure: A randomized, controlled trial. Ann Intern Med 2005;143:1-9. View abstract.
- Heaney RP, Dowell MS, Rafferty K, et al. Bioavailability of the calcium in fortified soy imitation milk, with some observations on method. Am J Clin Nutr 2000;71:1166-9. View abstract.
- Hebert JR, Hurley TG, Olendzki BC, et al. Nutritional and socioeconomic factors in relation to prostate cancer mortality: a cross-national study. J Natl Cancer Inst 1998;90:1637-47. View abstract.
- Henkel. FDA. Soy: Health Claims for Soy Protein, Questions About Other Components. May-June 2000. Available at: http://vm.cfsan.fda.gov/~dms/fdsoypr.html#health.
- Hiroyuki F, Tomohide Y, Kazunori O. Efficacy and safety of Touchi extract, an alpha-glucosidase inhibitor derived from fermented soybeans, in non-insulin-dependent diabetic mellitus. J Nutr Biochem 2001;12:351-56. View abstract.
- Ho SC, Chan SG, Yi Q, et al. Soy intake and the maintenance of peak bone mass in Hong Kong Chinese women. J Bone Miner Res 2001;16:1363-9. View abstract.
- Ho SC, Woo JL, Leung SS, et al. Intake of soy products is associated with better plasma lipid profiles in the Hong Kong Chinese population. J Nutr 2000;130:2590-3. View abstract.
- Hodgson JM, Puddey IB, Beilin LJ, et al. Effects of isoflavonoids on blood pressure in subjects with high-normal ambulatory blood pressure levels: a randomized controlled trial. Am J Hypertens 1999;12:47-53. View abstract.
- Hodgson JM, Puddey IB, Beilin LJ, et al. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 1998;128:728-32. View abstract.
- Hoie LH, Sjoholm A, Guldstrand M, et al. Ultra heat treatment destroys cholesterol-lowering effect of soy protein. Int J Food Sci Nutr 2006;57:512-9. View abstract.
- Horn-Ross PL, Hoggatt KJ, Lee MM. Phytoestrogens and thyroid cancer risk: the San Francisco Bay Area thyroid cancer study. Cancer Epidemiol Biomarkers Prev 2002;11:43-9. View abstract.
- Horn-Ross PL, John EM, Canchola AJ, et al. Phytoestrogen intake and endometrial cancer risk. J Natl Cancer Inst 2003;95:1158-64.. View abstract.
- Howes LG, Howes JB, Knight DC. Isoflavone therapy for menopausal flushes: a systematic review and meta-analysis. Maturitas 2006;55:203-11. View abstract.
- Hu X, Gao J, Zhang Q, et al. Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Mol Nutr Food Res. 2013;57(12):2147-54. View abstract.
- Huang MH, Luetters C, Buckwalter GJ, et al. Dietary genistein intake and cognitive performance in a multiethnic cohort of midlife women. Menopause 2006;13:621-30. View abstract.
- Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Can J Cardiol 2011;27(4):488-505. View abstract.
- Huntley AL, Ernst E. Soy for the treatment of perimenopausal symptoms--a systematic review. Maturitas 2004;47:1-9. View abstract.
- Hymowitz T. On the domestication of the soybean. Econ Bot. 1970;24(4):408-421.
- Imataka G, Mikami T, Yamanouchi H, et al. Vitamin D deficiency rickets due to soybean milk. J Paediatr Child Health 2004;40:154-5. View abstract.
- Izumi T, Piskula MK, Osawa S, et al. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J Nutr 2000;130:1695-9. View abstract.
- Jabbar MA, Larrea J, Shaw RA. Abnormal thyroid function tests in infants with congenital hypothyroidism: the influence of soy-based formula. J Am Coll Nutr. 1997;16(3):280-2. View abstract.
- Jacobsen BK, Knutsen SF, Fraser GE. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study. Cancer Causes Control 1998;9:553-7. View abstract.
- Jalili M, Hekmatdoost A, Vahedi H, et al. Co-Administration of soy isoflavones and Vitamin D in management of irritable bowel disease. PLoS One. 2016;11(8):e0158545. View abstract.
- Jamilian M, Asemi Z. The effect of soy intake on metabolic profiles of women with gestational diabetes mellitus. J Clin Endocrinol Metab. 2015;100(12):4654-61. View abstract.
- Jamilian M, Asemi Z. The effects of soy isoflavones on metabolic status of patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2016;101(9):3386-94 View abstract.
- Jayagopal V, Albertazzi P, Kilpatrick ES, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 2002;25:1709-14. View abstract.
- Jenkins DJ, Kendall CW, Connelly PW, et al. Effects of high- and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism 2002;51:919-24.. View abstract.
- Jenkins DJ, Kendall CW, D'Costa MA, et al. Soy consumption and phytoestrogens: effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. J Urol 2003;169:507-11.. View abstract.
- Jenkins DJ, Kendall CW, Jackson CJ, et al. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 2002;76:365-72. View abstract.
- Ji BT, Chow WH, Yang G, et al. Correspondence re: AH Wu et al, A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders. Cancer Epidemiol Biomarkers Prev 2001;10:570.
- Jones G, Dwyer T, Hynes K, et al. A randomized controlled trial of phytoestrogen supplementation, growth and bone turnover in adolescent males. Eur J Clin Nutr 2003;57:324-7.. View abstract.
- Jones JL, Daley BJ, Enderson BL, et al. Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 2002;68:575-7. View abstract.
- Ju YH, Doerge DR, Allred KF, et al. Dietary Genistein Negates the Inhibitory Effect of Tamoxifen on Growth of Estrogen-dependent Human Breast Cancer (MCF-7) Cells Implanted in Athymic Mice. Cancer Res 2002;62:2474-7 . View abstract.
- Kaari C, Haidar MA, Junior JMS, et al. Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study. Maturitas 2006;53:49-58. View abstract.
- Kapiotis S, Hermann M, Held I, et al. Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Arterioscler Thromb Vasc Biol 1997;17:2868-74.. View abstract.
- Keinan-Boker L, van Der Schouw YT, Grobbee DE, Peters PH. Dietary phytoestrogens and breast cancer risk. Am J Clin Nutr 2004;79:282-8. View abstract.
- Kerry N, Abbey M. The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis 1998;140:341-7.. View abstract.
- Kirkman, L. M., Lampe, J. W., Campbell, D. R., Martini, M. C., and Slavin, J. L. Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr Cancer 1995;24(1):1-12. View abstract.
- Kokubo Y, Iso H, Ishihara J, et al. (JPHC Study Group). Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: The Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation 2007;116:2553-62. View abstract.
- Krebs EE, Ensrud KE, MacDonald R, Wilt TJ. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol 2004;104:824-36. View abstract.
- Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: A randomized controlled trial. JAMA 2004;292:65-74. View abstract.
- Kritz-Silverstein D, Von Muhlen D, Barrett-Connor E, Bressel MA. Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause 2003;10:196-202. View abstract.
- Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002;137:805-13. View abstract.
- Kumar NB, Cantor A, Allen K et al. The specific role of isoflavones in reducing prostate cancer risk. Prostate 2004;59:141-7. View abstract.
- Kurzer M. Hormonal effects of soy isoflavones: Studies in premenopausal and postmenopausal women. J Nutr 2000;130:660-1.
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. View abstract.
- Kwak JH, Ahn CW, Park SH, et al. Weight reduction effects of a black soy peptide supplement in overweight and obese subjects: double blind, randomized, controlled study. Food Funct. 2012;3(10):1019-24. View abstract.
- Kwak JH, Kim M, Lee E, et al. Effects of black soy peptide supplementation on blood pressure and oxidative stress: a randomized controlled trial. Hypertens Res. 2013;36(12):1060-6. View abstract.
- Lamartiniere CA. Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 2000;71:1705S-7S.
- Lee HP, Gourley L, Duffy SW, et al. Dietary effects on breast-cancer risk in Singapore. Lancet 1991;337:1197-200. View abstract.
- Lee YS, Chen X, Anderson JJB. Physiological concentrations of genistein stimulate the proliferation and protect against free radical-induced oxidative damage of MC3T3-E1 osteoblast-like cells. Nutr Res 2001;21:1287-98.
- Lenn J, Uhl T, Mattacola C, et al. The effects of fish oil and isoflavones on delayed onset muscle soreness. Med Sci Sports Exerc 2002;34:1605-13. View abstract.
- Lewis JE, Nickell LA, Thompson LU, et al. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause 2006;13:631-42. View abstract.
- Lichtenstein AH. Got soy? Am J Clin Nutr 2001;73:667-8. View abstract.
- Lima SM, Bernardo BF, Yamada SS, et al. Effects of Glycine max (L.) Merr. soy isoflavone vaginal gel on epithelium morphology and estrogen receptor expression in postmenopausal women: a 12-week, randomized, double-blind, placebo-controlled trial. Maturitas. 2014;78(3):205-11. View abstract.
- Lissin LW, Cooke JP. Phytoestrogens and cardiovascular health. J Am Coll Cardiol 2000;35:1403-10. View abstract.
- Liu XX, Li SH, Chen JZ, et al. Effect of soy isoflavones on blood pressure: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2012;22(6):463-70. View abstract.
- Liu ZM, Ho SC, Woo J, Chen YM, Wong C. Randomized controlled trial of whole soy and isoflavone daidzein on menopausal symptoms in equol-producing Chinese postmenopausal women. Menopause. 2014;21(6):653-60. View abstract.
- Lu LJ, Anderson KE, Grady JJ, et al. Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Res 2000;60:4112-21. View abstract.
- Lu LJ, Anderson KE, Grady JJ, Nagamani M. Effects of an isoflavone-free soy diet on ovarian hormones in premenopausal women. J Clin Endocrinol Metab 2001;86:3045-52. View abstract.
- Lu LJ, Lin SN, Grady JJ, et al. Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure. Nutr Cancer 1996;26:289-302. View abstract.
- Lynch SR, Dassenko SA, Cook JD, et al. Inhibitory effect of a soybean-protein--related moiety on iron absorption in humans. Am J Clin Nutr 1994;60:567-72. View abstract.
- Macfarlane BJ, van der Riet WB, Bothwell TH, et al. Effect of traditional oriental soy products on iron absorption. Am J Clin Nutr. 1990;51(5):873-80. View abstract.
- Magee PJ, Rowland IR. Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr 2004;91:513-31. View abstract.
- Mahalko JR, Sandstead HH, Johnson LK, et al. Effect of consuming fiber from corn bran, soy hulls, or apple powder on glucose tolerance and plasma lipids in type II diabetes. Am J Clin Nutr 1984;39:25-34. View abstract.
- Massey LK, Palmer RG, Horner HT. Oxalate content of soybean seeds (Glycine max. Leguminosae), soyfoods, and other edible legumes. J Agric Food Chem 2001;49:4262-6. View abstract.
- Matvienko OA, Lewis DS, Swanson M, et al. A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am J Clin Nutr 2002;76:57-64. View abstract.
- McFadyen IJ, Chetty U, Setchell KDR, et al. A randomized double blind, cross over trial of soya protein for the treatment of cyclical breast pain.Breast 2000;9:271-6.. View abstract.
- McMichael-Phillips DF, Harding C, Morton M, et al. Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr 1998;68:1431S-5S. View abstract.
- Mei J, Yeung SS, Kung AW. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 2001;86:5217-21. View abstract.
- Merz-Demlow BE, Duncan AM, Wangen KE, et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 2000;71:1462-9. View abstract.
- Messina M, Barnes S, Setchell KD. Phyto-oestrogens and breast cancer. Lancet 1997;350:971-2.
- Messina M. Western soy intake is too low to produce health effects. Am J Clin Nutr. 2004;80(2):528-9.
- Miraghajani MS, Najafabadi MM, Surkan PJ, et al. Soy milk consumption and blood pressure among type 2 diabetic patients with nephropathy. J Ren Nutr. 2013;23(4):277-282.e1. View abstract.
- Morimoto Y, Maskarinec G, Park SY, et al. Dietary isoflavone intake is not statistically significantly associated with breast cancer risk in the Multiethnic Cohort. Br J Nutr. 2014;112(6):976-83. View abstract.
- Morin S. Isoflavones and bone health. Menopause 2004;11:239-41.
- Morito K, Hirose T, Kinjo J, et al. Interaction of phytoestrogens with estrogen receptors alpha and beta. Biol Pharm Bull 2001;24:351-6. View abstract.
- Moro GE, Warm A, Arslanoglu S, Miniello V. Management of bovine protein allergy: new perspectives and nutritional aspects. Ann Allergy Asthma Immunol 2002;89:91-6.. View abstract.
- Murkies A, Dalais FS, Briganti EM, et al. Phytoestrogens and breast cancer in postmenopausal women: a case control study. Menopause 2000;7:289-96. View abstract.
- Murkies AL, Lombard C, Strauss BJ, et al. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat. Maturitas 1995;21:189-95. View abstract.
- Nagata C, Inaba S, Kawakami N, et al. Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men. Nutr Cancer 2000;36:14-8. View abstract.
- Nagata C, Shimizu H, Takami R, et al. Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women. J Nutr 2003;133:797-800.. View abstract.
- Nagata C, Takatsuka N, Kawakami N, Shimizu H. Soy product intake and hot flashes in Japanese women: results from a community-based prospective study. Am J Epidemiol 2001;153:790-3. View abstract.
- Nahas EP, Neto JN, DeLuca L, et al. Benefits of soy germ isoflavone in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas 2004;48:372-80. View abstract.
- Nakagawa H, Yamamoto D, Kiyozuka Y, et al. Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines. J Cancer Res Clin Oncol 2000;126:448-54. View abstract.
- Neacsu M, Fyfe C, Horgan G, Johnstone AM. Appetite control and biomarkers of satiety with vegetarian (soy) and meat-based high-protein diets for weight loss in obese men: a randomized crossover trial. Am J Clin Nutr. 2014;100(2):548-58. View abstract.
- Nechuta SJ, Caan BJ, Chen WY, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. Am J Clin Nutr. 2012;96(1):123-32. View abstract.
- Nelson HD, Vesco KK, Haney E, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006;295:2057-71. View abstract.
- Nestel PJ, Yamashita T, Sasahara T, et al. Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 1997;17:3392-8. View abstract.
- Nettleton JA, Greany KA, Thomas W, et al. Plasma phytoestrogens are not altered by probiotic consumption in postmenopausal women with and without a history of breast cancer. J Nutr 2004:134:1998-2003. View abstract.
- Newton KM, Reed SD, Uchiyama S, et al. A cross-sectional study of equol producer status and self-reported vasomotor symptoms. Menopause. 2015;22(5):489-95. View abstract.
- Nicholls J, Lasley BL, Nakajima ST, et al. Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in women. J Nutr 2002;132:708-14.. View abstract.
- Nilausen K, Meinertz H. Variable lipemic response to dietary soy protein in healthy, normolipemic men. Am J Clin Nutr 1998;68:1380S-4S. View abstract.
- Nisley N, Klepser T. Phytoestrogens for the prevention and treatment of osteoporosis. Alt Med Alert 1999 Dec;138-42.
- Nomura AM, Hankin JH, Lee J, Stemmermann GN. Cohort study of tofu intake and prostate cancer: no apparent association. Cancer Epidemiol Biomarkers Prev 2004;13:2277-9. View abstract.
- Normen L, Dutta P, Lia A, et al. Soy sterol esters and B-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am J Clin Nutr 2000;71:908-13. View abstract.
- Nurmi T, Mazur W, Heinonen S, Kokkonen J, Adlercreutz H. Isoflavone content of the soy based supplements. J Pharm Biomed Anal. 2002;28(1):1-11.View abstract.
- Oliveira LP, de Jesus RP, Boulhosa RS, et al. Effect of soy protein supplementation in patients with chronic hepatitis C: a randomized clinical trial. World J Gastroenterol. 2012;18(18):2203-11. View abstract.
- Pawlowski JW, Martin BR, McCabe GP, et al. Impact of equol-producing capacity and soy-isoflavone profiles of supplements on bone calcium retention in postmenopausal women: a randomized crossover trial. Am J Clin Nutr. 2015;102(3):695-703. View abstract.
- Penalvo JL, Heinonen SM, Nurmi T, et al. Plant lignans in soy-based health supplements. J Agric Food Chem 2004;52:4133-8. View abstract.
- Persiani S, Sala F, Manzotti C, et al. Evaluation of levothyroxine bioavailability after oral administration of a fixed combination of soy isoflavones in post-menopausal female volunteers. Drug Res (Stuttg). 2016;66(3):136-40. View abstract.
- Persky VW, Turyk ME, Wang L, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75:145-53. View abstract.
- Petrakis NL, Barnes S, King EB, et al. Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiol Biomarkers Prev 1996;5:785-94. View abstract.
- Phipps WR, Wangen KE, Duncan AM, et al. Lack of effect of isoflavonic phytoestrogen intake on leptin concentrations in premenopausal and postmenopausal women. Fertil Steril 2001;75:1059-64.. View abstract.
- Pino AM, Valladares LE, Palma MA, et al. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab 2000;85:2797-800. View abstract.
- Potter SM, Baum JA, Teng H, et al. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68:1375S-9S. View abstract.
- Puska P, Korpelainen V, Hoie LH, et al. Soy in hypercholesterolaemia: a double-blind, placebo-controlled trial. Eur J Clin Nutr 2002;56:352-7. View abstract.
- Quaas AM, Kono N, Mack WJ, et al. Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial. Menopause. 2013;20(8):840-4. View abstract.
- Quella SK, Loprinzi CL, Barton DL, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: a North Central Cancer Treatment Group trial. J Clin Oncol 2000;18:1068-74. View abstract.
- Roemheld-Hamm B, Dahl NV. Herbs, menopause, and dialysis. Semin Dial 2002;15:53-9.. View abstract.
- Sacks FM, Lichtenstein A, Van Horn L, et al. Soy protein, isoflavones, and cardiovascular health. An American Heart Association Science Advisory for Professionals from the Nutrition Committee. Circulation 2006;113:1034-44. View abstract.
- Sartippour MR, Rao JY, Apple S, et al. A pilot clinical study of short-term isoflavone supplements in breast cancer patients. Nutr Cancer 2004;49:59-65. View abstract.
- Scambia G, Mango D, Signorile PG, et al. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause 2000;7:105-11. View abstract.
- Schabath MB, Hernandez LM, Wu X, et al. Dietary phytoestrogens and lung cancer risk. JAMA 2005;294:1493-1504. View abstract.
- Scheiber MD, Liu JH, Subbiah MT, et al. Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women. Menopause 2001;8:384-92. View abstract.
- Secreto G, Chiechi LM, Amadori A, et al. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 2004;47:11-20. View abstract.
- Setchell KD, Brown NM, Desai P, et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 2001;131:1362S-75S. View abstract.
- Setchell KD, Cassidy A. Dietary isoflavones: biological effects and relevance to human health. J Nutr 1999;129:758S-67S. View abstract.
- Setchell KD, Zimmer-Nechemias L, Cai J, Heubi JE. Exposure of infants to phyto-oestrogens from soy-based infant formula. Lancet 1997;350:23-7. View abstract.
- Setchell KD. Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. J Nutr 2000;130:654S-5S. View abstract.
- Setchell KDR, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol - A clue to the effectiveness of soy and its isoflavones. J Nutr 2002;132:3577-84. View abstract.
- Setchell KDR, Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 2003;78:593S-609S. View abstract.
- Shao ZM, Shen ZZ, Fontana JA, Barsky SH. Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines. Anticancer Res 2000;20:2409-16. View abstract.
- Shelnutt SR, Cimino CO, Wiggins PA, et al. Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage. Am J Clin Nutr 2002;76:588-94.. View abstract.
- Shenoy S, Bedi R, Sandhu JS. Effect of soy isolate protein and resistance exercises on muscle performance and bone health of osteopenic/osteoporotic post-menopausal women. J Women Aging. 2013;25(2):183-98. View abstract.
- Shu XO, Jin F, Dai Q, et al. Soyfood intake during adolescence and subsequent risk of breast cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2001;10:483-88. View abstract.
- Shulman KI, Walker SE. Refining the MAOI diet: tyramine content of pizzas and soy products. J Clin Psychiatry 1999;60:191-3. View abstract.
- Simão AN, Lozovoy MA, Bahls LD, et al. Blood pressure decrease with ingestion of a soya product (kinako) or fish oil in women with the metabolic syndrome: role of adiponectin and nitric oxide. Br J Nutr. 2012;108(8):1435-42. View abstract.
- Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 2000;85:1297-301. View abstract.
- Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 2000;85:1297-301. View abstract.
- Sirtori CR, Pazzucconi F, Colombo L, et al. Double-blind study of the addition of high-protein soya milk v. cows' milk to the diet of patients with severe hypercholesterolemia and resistance to or intolerance of statins. Br J Nutr 1999;82:91-6. View abstract.
- Skopnik H, Heimann G. [Manifestation of intolerance to cow's milk protein in mucoviscidosis with the symptom triad of hypoproteinemia, edema and anemia]. Klin Padiatr 1987;199:453-6. View abstract.
- Slavin J. Nutritional benefits of soy protein and soy fiber. J Am Diet Assoc. 1991;91(7):816-9. View abstract.
- Smith LJ, Holbrook JT, Wise R, et al. Dietary intake of soy genistein is associated with lung function in patients with asthma. J Asthma 2004;41:833-43. View abstract.
- Smith LJ, Kalhan R, Wise RA, et al.; American Lung Association Asthma Clinical Research Centers. Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial. JAMA. 2015;313(20):2033-43. View abstract.
- Somekawa Y, Chiguchi M, Ishibashi T, Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001;97:109-15. View abstract.
- Sonoda T, Nagata Y, Mori M, et al. A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet. Cancer Sci 2004;95:238-42. . View abstract.
- Soroka N, Silverberg DS, Greemland M, et al. Comparison of a vegetable-based (soya) and an animal-based low-protein diet in predialysis chronic renal failure patients. Nephron 1998;79:173-80. View abstract.
- Spence LA, Lipscomb ER, Cadogan J, et al. The effect of soy protein and soy isoflavones on calcium metabolism in postmenopausal women: a randomized crossover study. Am J Clin Nutr 2005;81:916-22. View abstract.
- St Germain A, Peterson CT, Robinson JG, Alekel DL. Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment. Menopause 2001;8:17-26. View abstract.
- Stearns V, Hayes DF. Cooling off hot flashes. J Clin Oncol 2002;20:1436-8. View abstract.
- Stephenson TJ, Anderson JW, Fanti P. Soy protein use in early diabetic nephropathy. Altern Ther Health Med 2001;7:S31-2.
- Strom BL, Schinnar R, Ziegler EE, et al. Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA 2001;286:807-14. View abstract.
- Sun CL, Yuan JM, Arakawa K, et al. Dietary soy and increased risk of bladder cancer: the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev 2002;11:1674-7. View abstract.
- Tai TY, Tsai KS, Tu ST, et al. The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study. Osteoporos Int. 2012;23(5):1571-80. View abstract.
- Takatsuka N, Nagata C, Kurisu Y, et al. Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. Prev Med 2000;31:308-14. View abstract.
- Taku K, Melby MK, Kronenberg F, Kurzer MS, Messina M. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials. Menopause. 2012;19(7):776-90. View abstract.
- Taku K, Umegaki K, Sato Y, et al. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 2007;85:1148-56. View abstract.
- Tanos V, Brzezinski A, Drize O, et al. Synergistic inhibitory effects of genistein and tamoxifen on human dysplastic and malignant epithelial breast cells in vitro. Eur J Obstet Gynecol Reprod Biol 2002;102:188-94. View abstract.
- Teede HJ, Dalais FS, Kotsopoulos D, et al. Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women. J Clin Endocrinol Metab 2005;90:1936-41. View abstract.
- Teede HJ, Dalais FS, Kotsopoulos D, et al. Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 2001;86:3053-60. View abstract.
- Teixeira SR, Potter SM, Weigel R, et al. Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. Am J Clin Nutr 2000;71:1077-84. View abstract.
- Teixeira SR, Tappenden KA, Carson L, et al. Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy. J Nutr 2004;134:1874-80. View abstract.
- Tham DM, Gardner CD, Haskell WL. Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 1998;83:2223-35. View abstract.
- This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. View abstract.
- Thorp AA, Howe PR, Mori TA, et al. Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. Am J Clin Nutr 2008;88:298-304. View abstract.
- Tikkanen MJ, Wahala K, Ojala S, et al. Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA 1998;95:3106-10.. View abstract.
- Tonstad S, Smerud K, Hoie L. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects. Am J Clin Nutr 2002;76:78-84. View abstract.
- Tranche S, Brotons C, Pascual de la Pisa B, Macías R, Hevia E, Marzo-Castillejo M. Impact of a soy drink on climacteric symptoms: an open-label, crossover, randomized clinical trial. Gynecol Endocrinol. 2016;32(6):477-82. View abstract.
- Travis RC, Allen NE, Appleby PN, et al. A prospective study of vegetarianism and isoflavone intake in relation to breast cancer risk in British women. Int J Cancer 2008;122:705-10. View abstract.
- Trock BJ, Hilakivi-Clarke L, Clarke R. Meta-analysis of soy intake and breast cancer risk. J Natl Cancer Inst 2006;98:459-71. View abstract.
- Tsai AC, Vinik AI, Lasichak A, Lo GS. Effects of soy polysaccharide on postprandial plasma glucose, insulin, glucagon, pancreatic polypeptide, somatostatin, and triglyceride in obese diabetic patients. Am J Clin Nutr 1987;45:596-601. View abstract.
- Unfer V, Casini ML, Costabile L, et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004;82:145-8. View abstract.
- Upmalis DH, Lobo R, Bradley L, et al. Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: A multicenter, double-blind, randomized, placebo-controlled study. Menopause 2000;7:236-42. View abstract.
- van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, et al. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation 2005;111:465-71. View abstract.
- Van Horn L, Liu K, Gerber J, et al. Oats and soy in lipid-lowering diets for women with hypercholesterolemia: is there synergy? J Am Diet Assoc 2001;101:1319-25. View abstract.
- Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol 2002;20:1449-55. View abstract.
- Vanderhoof JA, Murray ND, Paule CL, et al. Use of soy fiber in acute diarrhea in infants and toddlers. Clin Pediatr (Phila) 1997;36:135-9. View abstract.
- Verhoeven MO, van der Mooren MJ, van de Weijer PH, et al. CuraTrial Research Group. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. Menopause 2005;12:412-20. View abstract.
- Vincent A, Fitzpatrick LA. Soy isoflavones: are they useful in menopause? Mayo Clin Proc 2000;75:1174-84. View abstract.
- Vincent A, Ruan M, Fitzpatrick LA. Genistein, a phytoestrogen, inhibits proliferation of vascular smooth muscle cells: a possible cardioprotective mechanism. Fertil Steril 2000;74:S25.
- Wu AH, Spicer D, Garcia A, et al. Double-blind randomized 12-month soy intervention had no effects on breast MRI fibroglandular tissue density or mammographic density. Cancer Prev Res (Phila). 2015;8(10):942-51. View abstract.
- Wu AH, Stanczyk FZ, Hendrich, S et al. Effects of soy foods on ovarian function in premenopausal women. Br J Cancer 2000;82:1879-86. View abstract.
- Wu AH, Stanczyk FZ, Martinez C, et al. A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women. Am J Clin Nutr 2005;81:1133-41. View abstract.
- Wu AH, Yang D, Pike MC. A meta-analysis of soyfoods and risk of stomach cancer: the problem of potential confounders. Cancer Epidemiol Biomarkers Prev 2000;9:1051-8. View abstract.
- Wu SH, Liu Z. Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies. Nutr Cancer. 2013;65(5):625-32. View abstract.
- Xu WH, Zheng W, Xiang YB, et al. Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. BMJ 2004;328:1285. View abstract.
- Xu X, Duncan AM, Wangen KE, Kurzer MS. Soy consumption alters endogenous estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2000;9:781-6. View abstract.
- Xu X, Wang HJ, Murphy PA, Hendrich S. Neither background diet nor type of soy food affects short-term isoflavone bioavailability in women. J Nutr 2000;130:798-801. View abstract.
- Yagami A, Suzuki K, Nakamura M, et al. Case of anaphylactic reaction to soy following percutaneous sensitization by soy-based ingredients in cosmetic products. J Dermatol. 2015;42(9):917-8. View abstract.
- Yamamoto S, Sobue T, Kobayashi M, et al. Soy, isoflavones, and breast cancer risk in Japan. J Natl Cancer Inst 2003;95:906-13. View abstract.
- Yang G, Shu XO, Chow WH, et al. Soy food intake and risk of lung cancer: evidence from the Shanghai Women's Health Study and a meta-analysis. Am J Epidemiol. 2012;176(10):846-55. View abstract.
- Zand RS, Jenkins DJ, Diamandis EP. Steroid hormone activity of flavonoids and related compounds. Breast Cancer Res Treat 2000;62:35-49. View abstract.
- Zhang FF, Haslam DE, Terry MB, et al. Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry. Cancer. 2017 Mar 6. doi: 10.1002/cncr.30615. View abstract.
- Zhang GQ, Chen JL, Liu Q, Zhang Y, Zeng H, Zhao Y. Soy intake is associated with lower endometrial cancer risk: A systematic review and meta-analysis of observational studies. Medicine (Baltimore). 2015;94(50):e2281. View abstract.
- Zhang J, Liu J, Su J, Tian F. The effects of soy protein on chronic kidney disease: a meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2014;68(9):987-93. View abstract.
- Zhang X, Shu XO, Li H, et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 2005;165:1890-95. View abstract.
- Zhang XM, Zhang YB, Chi MH. Soy protein supplementation reduces clinical indices in type 2 diabetes and metabolic syndrome. Yonsei Med J. 2016;57(3):681-9. View abstract.
- Zhang YB, Chen WH, Guo JJ, et al. Soy isoflavone supplementation could reduce body weight and improve glucose metabolism in non-Asian postmenopausal women--a meta-analysis. Nutrition. 2013;29(1):8-14. View abstract.
- Zhao Y, Martin BR, Weaver CM. Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow's milk in young women. J Nutr 2005;135:2379-82. View abstract.
- Ziegler RG, Hoover RN, Pike MC, et al. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 1993;85:1819-27.. View abstract.
- Zittermann A, Geppert J, Baier S, et al. Short-term effects of high soy supplementation on sex hormones, bone markers, and lipid parameters in young female adults. Eur J Nutr 2004;43:100-8. View abstract.
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