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Diabetes Health Center

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Antioxidant Soothes Diabetic Neuropathy

Alpha Lipoic Acid Decreases Burning, Cutting Pain
WebMD Health News

April 11, 2003 -- Alpha lipoic acid, an over-the-counter antioxidant supplement, eases the burning, pain, and numbness associated with diabetic neuropathy, say researchers. In a new study, alpha lipoic acid offered quick and dramatic relief without the side effects of drugs currently used.

After just 14 treatments, patients with diabetic neuropathy who received high doses of intravenous alpha lipoic acid had a threefold improvement in pain, numbness and other symptoms compared with those treated with placebo.

"But it didn't act only as a pain medication," says researcher and Mayo Clinic neurologist Peter Dyck, MD. "Alpha lipoic acid seems to actually change the metabolism of the nerve or blood supply to the nerve, and we noted some relief in symptoms."

His study, reported in the March issue of Diabetes Care, involved 120 patients with the most common form of diabetic neuropathy, which causes pain, numbness, and a burning sensation and often leads to foot problems.

Half of the patients received five treatments a week consisting of 600 mg of alpha lipoic acid in intravenous form, while the others got a placebo. They didn't know which substance they received. In just 2½ weeks, the alpha lipoic acid patients reported -- and the researchers noted in examinations -- dramatic improvements in symptoms, including a six-point drop in pain levels on a 10-point scale. The placebo group reported a two-point improvement in pain relief.

Alpha lipoic acid is available over-the-counter in dosages of 50 to 150 mg. Dyck is currently conducting a study measuring the efficacy of those capsules in other diabetic patients. The powerful antioxidant has been used for nearly 30 years in Europe to treat diabetic neuropathy and is being studied in the U.S. as a treatment for HIV, Parkinson's disease, Alzheimer's disease, and other conditions.

"I'm glad to see we have now jumped the Atlantic and the evidence gathered by German researchers decades ago has been read and is being considered by prominent American researchers," says Richard A. Passwater, PhD, retired biochemist who has studied antioxidant treatments since the 1960s and wrote the book, Lipoic Acid: The Metabolic Antioxidant. He says that he is not surprised by Dyck's findings.

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