Skip to content
My WebMD Sign In, Sign Up

Diabetes Health Center

Font Size
A
A
A

Antioxidant Soothes Diabetic Neuropathy

Alpha Lipoic Acid Decreases Burning, Cutting Pain
By
WebMD Health News

April 11, 2003 -- Alpha lipoic acid, an over-the-counter antioxidant supplement, eases the burning, pain, and numbness associated with diabetic neuropathy, say researchers. In a new study, alpha lipoic acid offered quick and dramatic relief without the side effects of drugs currently used.

After just 14 treatments, patients with diabetic neuropathy who received high doses of intravenous alpha lipoic acid had a threefold improvement in pain, numbness and other symptoms compared with those treated with placebo.

"But it didn't act only as a pain medication," says researcher and Mayo Clinic neurologist Peter Dyck, MD. "Alpha lipoic acid seems to actually change the metabolism of the nerve or blood supply to the nerve, and we noted some relief in symptoms."

His study, reported in the March issue of Diabetes Care, involved 120 patients with the most common form of diabetic neuropathy, which causes pain, numbness, and a burning sensation and often leads to foot problems.

Half of the patients received five treatments a week consisting of 600 mg of alpha lipoic acid in intravenous form, while the others got a placebo. They didn't know which substance they received. In just 2½ weeks, the alpha lipoic acid patients reported -- and the researchers noted in examinations -- dramatic improvements in symptoms, including a six-point drop in pain levels on a 10-point scale. The placebo group reported a two-point improvement in pain relief.

Alpha lipoic acid is available over-the-counter in dosages of 50 to 150 mg. Dyck is currently conducting a study measuring the efficacy of those capsules in other diabetic patients. The powerful antioxidant has been used for nearly 30 years in Europe to treat diabetic neuropathy and is being studied in the U.S. as a treatment for HIV, Parkinson's disease, Alzheimer's disease, and other conditions.

"I'm glad to see we have now jumped the Atlantic and the evidence gathered by German researchers decades ago has been read and is being considered by prominent American researchers," says Richard A. Passwater, PhD, retired biochemist who has studied antioxidant treatments since the 1960s and wrote the book, Lipoic Acid: The Metabolic Antioxidant. He says that he is not surprised by Dyck's findings.

Dyck, who conducted the study with Russian researchers, says that alpha lipoic acid offered several benefits to his patients with diabetes. "It is a very strong antioxidant and it is assumed that oxidation plays a role in the development of diabetes," he tells WebMD. This means the substance -- produced in very small amounts by the body and also found in foods such as potatoes and red meat -- protects against damage by cell-ravaging "free radicals." This oxidation process is implicated in various diseases, including heart disease, cancer, and neurologic conditions including Parkinson's and Alzheimer's.

"Besides that, alpha lipoic acid also seems to promote better blood flow and oxygen to the nerves and may also promote the entry of glucose and the breakdown of it into cells," he says.

Is This Normal? Get the Facts Fast!

Check Your Blood Sugar Level Now
What type of diabetes do you have?
Your gender:

Get the latest Diabetes newsletter delivered to your inbox!


or
Answer:
Low
0-69
Normal
70-130
High
131+

Your level is currently

If the level is below 70 and you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.

People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.

Congratulations on taking steps to manage your health.

However, it's important to continue to track your numbers so that you can make lifestyle changes if needed. If you are pregnant always consult with your physician.

Your level is high if this reading was taken before eating. Aim for 70-130 before meals and less than 180 two hours after meals.

Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.

One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.

Did You Know Your Lifestyle Choices
Affect Your Blood Sugar?

Use the Blood Glucose Tracker to monitor
how well you manage your blood sugar over time.

Get Started

This tool is not intended for women who are pregnant.

Start Over

Step:  of 

Today on WebMD

Woman holding cake
Slideshow
feet
Slideshow
 
man organizing pills
Slideshow
Close up of eye
Slideshow
 

Woman serving fast food from window
Video
Can Vinegar Treat Diabetes
Video
 
Middle aged person
Tool
are battery operated toothbrushes really better
Video
 

Prediabetes How to Prevent Type 2 Diabetes
Article
type 2 diabetes
Slideshow
 
food fitness planner
Tool
Are You at Risk for Dupuytrens Contracture
Article
 

WebMD Special Sections