10 Genes Linked to Type 2 Diabetes
Researchers Say Findings Could Lead to New Treatments for Diabetes Patients
April 26, 2007 -- Researchers have identified 10 genetic variants that may
make type 2 diabetes more likely.
The findings may lead to new treatments for type 2 diabetes, note the
They included Michael Boehnke, PhD, who is the Richard G. Cornell Collegiate
Professor of Biostatistics at the University of Michigan School of Public
Boehnke's team studied DNA from 2,376 people with type 2 diabetes and from
2,432 people without diabetes in Finland.
The researchers discovered four gene variants that were more common in the
diabetes patients. Those gene variants are found near the following genes:
IGF2BP2, CDKAL1, and CDKN2A/CDKN2B.
The scientists also confirmed six other gene variants that had previously
been linked to type 2 diabetes. Those gene variants are located near the
TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 genes.
All in all, that adds up to 10 genetic variants that can be "confidently
identified" as being associated with type 2 diabetes risk, write Boehnke
The gene variants may make good targets for new type 2 diabetes treatments,
Boehnke's team writes in Science Express, the advance online edition of
Another new report on the genetics of type 2 diabetes appears in the advance
online edition of Nature Genetics.
The researchers included Valgerdur Steinthorsdottir, PhD, of Decode
Genetics, a biopharmaceutical company in Iceland.
They screened genes from 6,351 people with type 2 diabetes and 14,829 people
without diabetes in Iceland, Denmark, Philadelphia, the Netherlands, Hong Kong,
Nigeria, and Ghana.
The study shows that the CDKAL1 gene variant was associated with type 2
diabetes in people of European or Chinese ancestry.