Drug Combo May Prevent Diabetes
Study Shows Low Doses of Avandia, Metformin Ward Off Diabetes for at-Risk Patients
Avandia: Safe at Any Dose? continued...
Mezitis agrees, but he'd like to see this supported by a clinical trial.
"Yes, we can make the association that Actos would work the same way, but we don't have a study suggesting that," he says. "So I would feel more comfortable having a study first before recommending another medication."
The Zinman trial was funded by GlaxoSmithKline, and Zinman reports receiving consulting fees, honoraria, and grant support from the company. However, he says the study was free of company influence and that the study investigators initiated the study, drew their conclusions, and published their findings without any company influence.
Mezitis reports that he previously served on GlaxoSmithKline's speakers bureau but withdrew when issues about Avandia cardiovascular safety first arose.
The Zinman study appears in the June 3 online edition of The Lancet.