People with prediabetes who took the drug had a 72% reduction in diabetes risk, compared to patients who did not take it, researchers report.
They estimate that one case of diabetes could be prevented if 18 high-risk people were treated with the drug for a year.
The study appears in the March 24 issue of The New England Journal of Medicine.
The findings suggest that millions of people at high risk for diabetes may benefit from taking Actos, but experts urge caution.
Actos (pioglitazone) is in the same drug class as the controversial diabetes drug Avandia. The FDA severely restricted Avandia’s use last fall due to concerns that its use may be associated with an increase in heart attack risk.
Similar concerns have not been raised about Actos, and there are even suggestions that the drug protects the heart. But its use has been linked to fractures related to bone loss, weight gain, fluid retention, and other side effects.
American Diabetes Association vice president for medical affairs Sue Kirkman, MD, says patients at risk for type 2 diabetes should first be encouraged to make lifestyle changes before considering any drug treatment.
“Anytime we talk about long-term drug treatment for prevention, we have to have a very high reassurance that these treatments are both safe and effective,” she says.
Close to 79 million people in the U.S. have prediabetes, meaning that their blood sugar is higher than normal but not yet high enough to be considered diabetes.
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If the level is below 70 or you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.
People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.
Congratulations on taking steps to manage your health.
However, it's important to continue to track your numbers so that you can make lifestyle changes if needed. If you are pregnant always consult with your physician.
Your level is high if this reading was taken before eating. Aim for 70-130 before meals and less than 180 two hours after meals.
Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.
One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.
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