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Diabetes Health Center

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Study: New Drug Bardoxolone Improves Kidney Function

In Phase II Trial, New Kidney Drug Improved Kidney Function About 30%
WebMD Health News
Reviewed by Laura J. Martin, MD

June 24, 2011 -- A new drug appears to improve kidney function in people with type 2 diabetes who have chronic kidney disease, new research suggests.

The drug, known as bardoxolone methyl, works in a new way, says researcher David Warnock, MD, the Hilda B. Anderson professor of medicine at the University of Alabama at Birmingham. He is slated to present the results of the phase II trial of the drug today at the European Renal Association-European Dialysis and Transplant Association Congress in Prague.

"This is a promising new treatment that may change the course, the whole way we approach severe kidney disease in diabetics," Warnock tells WebMD.

The results are also published in The New England Journal of Medicine.

Diabetes is a major cause of kidney disease, which boosts the risk of kidney failure and the need for dialysis.

"There are 26 million Americans who have chronic kidney disease," Warnock says. "There are 500,000 on dialysis."

The hope, Warnock says, is to improve kidney function with the drug enough to delay or prevent the need for dialysis, which costs about $75,000 a year per patient.

Lynda Szczech, MD, president of the National Kidney Foundation, who reviewed the findings for WebMD, said the results look impressive, but she awaits results from the final clinical trial (phase III), now under way.

New Drug for Kidney Disease: Study Details

In the study, Warnock and his colleagues looked at three doses of the drug -- 25, 75, and 150 milligrams daily. They compared the drug treatment to placebo. The patients remained on other medications, such as blood pressure-lowering drugs, with the bardoxolone added on.

The new drug is an antioxidant that reduces inflammation, working in a new way. The reduction in inflammation leads to improved kidney function, Warnock says.

In all, they evaluated 227 patients, average age 67. The patients were equally divided into the placebo group and the three drug groups.

The researchers followed them for 52 weeks, evaluating the effect at 24 weeks and at 52 weeks.

Compared to placebo, people on the drug had an increase in their average GFR, a measure of kidney function.

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