Skip to content
My WebMD Sign In, Sign Up

Diabetes Health Center

Font Size

Study: New Drug Bardoxolone Improves Kidney Function

In Phase II Trial, New Kidney Drug Improved Kidney Function About 30%

New Drug for Kidney Disease: Study Details continued...

Side effects were more common in the drug-treated groups, but most were mild to moderate, the researchers say. Muscle spasms affected 61% in the middle-dose group, but generally went away with time. Other side effects included elevated liver enzymes, nausea, decreased appetite, and low magnesium.

One death occurred in the 75-mg group after the patient had cardiac bypass surgery.

Warnock was an investigator for the phase II study. He is not an investigator for the phase III study, just launched. He is now a consultant for Reata Pharmaceuticals, which supported the phase II study. (Phase II trials focus on effectiveness and provide more safety information. Phase III studies include larger groups and confirm effectiveness, monitor side effects, and collect other information.)

New Drug for Kidney Disease: Perspective

Szczech of the National Kidney Foundation says the results from the current study look impressive but that ''the real safety and efficacy will be found in phase III."

However, she says, based on the way the drug works, it is ''entirely plausible that this will pan out." Part of the reason, she says, is the novel way the medicine works on kidney disease. "This is the first drug that would come at it from the inflammation pathway.''

Patients on dialysis are often financially devastated, she says, even if they have some insurance coverage.

Szczech is also associate professor of medicine at Duke University School of Medicine, Durham, N.C.

She was not involved in the study but has been a consultant for Abbott. Abbott and Reata have a partnership to develop and market the drug outside the U.S. The phase III trial results are expected in 2013.

1 | 2

Is This Normal? Get the Facts Fast!

Check Your Blood Sugar Level Now
What type of diabetes do you have?
Your gender:

Get the latest Diabetes newsletter delivered to your inbox!


Your level is currently

If the level is below 70 and you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.

People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.

Congratulations on taking steps to manage your health.

However, it's important to continue to track your numbers so that you can make lifestyle changes if needed. If you are pregnant always consult with your physician.

Your level is high if this reading was taken before eating. Aim for 70-130 before meals and less than 180 two hours after meals.

Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.

One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.

Did You Know Your Lifestyle Choices
Affect Your Blood Sugar?

Use the Blood Glucose Tracker to monitor
how well you manage your blood sugar over time.

Get Started

This tool is not intended for women who are pregnant.

Start Over

Step:  of 

Today on WebMD

Woman holding cake
man organizing pills
Close up of eye

Woman serving fast food from window
Can Vinegar Treat Diabetes
Middle aged person
are battery operated toothbrushes really better

Prediabetes How to Prevent Type 2 Diabetes
type 2 diabetes
food fitness planner
Are You at Risk for Dupuytrens Contracture

WebMD Special Sections