When you're depressed, muscle aches in your legs and feet can seem to come out of nowhere. They may not be related to any known injury or strain, and certainly need medical evaluation.
But depression and physical pain are closely related. Depression makes us more aware of vague aches and pains we would otherwise not notice. It also intensifies the feeling of pain and discomfort.
Could your muscle aches be related to depression? One way to find out is to keep a symptom diary. Print out this symptom...
"This is true across all countries, all cultures, all income levels, across all levels of success -- women have higher rates of depression," says Myrna M. Weissman, PhD, an epidemiologist and psychiatry professor at Columbia University School of Medicine in New York.
"Before puberty, rates of depression are about equal between boys and girls," she tells WebMD. "At puberty, the rates skyrocket in girls. There are men who suffer from depression, but not anything near the rate in women."
In 1999, Surgeon General David Satcher, MD, noted these same rates in his report on mental health. Although women have more opportunities than ever before, they still fight a bigger battle against depression, anxiety, and other mental health problems.
Under the Skull
Using sophisticated brain imaging, researchers have found that men's and women's brains are indeed built differently.
In one study, a group of researchers found that men's brains synthesize more of the mood-lifting brain chemical serotonin than women's brains do -- 52% more.
For women, antidepressant drugs that affect serotonin, like Prozac, Paxil, and Zoloft, work better, reports Susan G. Kornstein, MD, head of the outpatient psychiatry clinic at the Virginia Commonwealth University.
Serotonin found primarily in a brain region called the amygdala, where emotions are processed, explains Stephan Hamann, PhD, a psychology researcher at Emory University in Atlanta.
This is the "fight-or-flight" center of the brain, the region that registers anxiety, fear, joy, stress, even lust, he says.
Emotional Secrets of the Amygdala
The amygdala is an almond-shaped area of the brain that controls emotion. In adulthood, the size of a man's amygdala doesn't differ much from a woman's. However, recent studies have found that when men and women look at photographs, they register the memory on opposite sides of the amygdala.